SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OMT'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.68A 1d4yB-2vdcA:
undetectable
1d4yB-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp.
PCC
6803)
5 / 11 LEU A 155
ALA A 115
VAL A 154
LEU A  19
HIS A 112
None
OMT  A 114 (-3.1A)
OCS  A 150 ( 3.9A)
None
OMT  A 114 ( 3.9A)
1.42A 1kt7A-2f1kA:
undetectable
1kt7A-2f1kA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
1.30A 1lf9A-2vdcA:
0.0
1lf9A-2vdcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
1.24A 1lf9B-2vdcA:
0.0
1lf9B-2vdcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
None
None
None
None
OMT  A2473 (-3.8A)
1.08A 1rjdA-2vdcA:
undetectable
1rjdA-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
None
None
None
None
OMT  A2473 (-3.8A)
1.07A 1rjdB-2vdcA:
undetectable
1rjdB-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
None
None
None
None
OMT  A2473 (-3.8A)
1.05A 1rjdC-2vdcA:
undetectable
1rjdC-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
1.12A 1ulvA-2vdcA:
0.0
1ulvA-2vdcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ARG A 351
GLY A 366
VAL A   3
GLU A 978
HIS A  30
None
None
None
OMT  A2473 ( 4.9A)
None
1.43A 1vhwA-2vdcA:
undetectable
1vhwD-2vdcA:
undetectable
1vhwA-2vdcA:
10.85
1vhwD-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 ARG A 351
GLY A 366
VAL A   3
GLU A 978
HIS A  30
None
None
None
OMT  A2473 ( 4.9A)
None
1.44A 1vhwB-2vdcA:
undetectable
1vhwF-2vdcA:
undetectable
1vhwB-2vdcA:
10.85
1vhwF-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ARG A 351
GLY A 366
VAL A   3
GLU A 978
HIS A  30
None
None
None
OMT  A2473 ( 4.9A)
None
1.44A 1vhwC-2vdcA:
undetectable
1vhwE-2vdcA:
undetectable
1vhwC-2vdcA:
10.85
1vhwE-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 HIS A  30
ARG A 351
GLY A 366
VAL A   3
GLU A 978
None
None
None
None
OMT  A2473 ( 4.9A)
1.45A 1vhwA-2vdcA:
undetectable
1vhwD-2vdcA:
undetectable
1vhwA-2vdcA:
10.85
1vhwD-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 HIS A  30
ARG A 351
GLY A 366
VAL A   3
GLU A 978
None
None
None
None
OMT  A2473 ( 4.9A)
1.43A 1vhwC-2vdcA:
undetectable
1vhwE-2vdcA:
undetectable
1vhwC-2vdcA:
10.85
1vhwE-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 HIS A  30
ARG A 351
GLY A 366
VAL A   3
GLU A 978
None
None
None
None
OMT  A2473 ( 4.9A)
1.44A 1vhwB-2vdcA:
undetectable
1vhwF-2vdcA:
undetectable
1vhwB-2vdcA:
10.85
1vhwF-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans)
5 / 12 GLY A 113
GLY A 115
ILE A  82
LEU A  84
VAL A  35
ACT  A 502 ( 4.6A)
GOL  A 503 (-4.6A)
None
OMT  A  89 ( 4.4A)
None
1.09A 2hmyB-4q22A:
undetectable
2hmyB-4q22A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 ILE A 974
GLY A1012
TYR A 211
GLU A 978
ARG A 351
None
None
None
OMT  A2473 ( 4.9A)
None
1.18A 2pivA-2vdcA:
0.0
2pivA-2vdcA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ILE A 974
GLY A1012
TYR A 211
GLU A 978
ARG A 351
None
None
None
OMT  A2473 ( 4.9A)
None
1.28A 2piwA-2vdcA:
undetectable
2piwA-2vdcA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.66A 3el9A-2vdcA:
undetectable
3el9A-2vdcA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp.
PCC
6803)
4 / 6 ALA A 236
HIS A 179
VAL A 174
HIS A 170
None
None
OMT  A 114 ( 4.7A)
None
1.21A 3nneG-2f1kA:
undetectable
3nneG-2f1kA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.71A 3spkB-2vdcA:
undetectable
3spkB-2vdcA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp.
PCC
6803)
5 / 12 LEU A 164
GLY A 111
HIS A 112
ALA A 101
PRO A 167
None
None
OMT  A 114 ( 3.9A)
None
None
1.29A 3tm4A-2f1kA:
6.7
3tm4A-2f1kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp.
PCC
6803)
5 / 12 LEU A 164
GLY A 111
HIS A 112
ALA A 101
PRO A 167
None
None
OMT  A 114 ( 3.9A)
None
None
1.32A 3tm4B-2f1kA:
6.7
3tm4B-2f1kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1021
LEU A1000
GLY A1012
SER A 212
ARG A 210
None
None
None
None
OMT  A2473 (-3.9A)
1.13A 4djfB-2vdcA:
8.6
4djfB-2vdcA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)
2isa CATALASE
(Aliivibrio
salmonicida)
4 / 9 TYR A 337
LYS A  54
HIS A  54
PHE A 140
HEM  A 486 (-4.1A)
OMT  A  53 (-3.0A)
HEM  A 486 (-3.4A)
HEM  A 486 (-3.4A)
1.35A 4jvlA-2isaA:
undetectable
4jvlA-2isaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 HIS A 208
LEU A 228
GLY A 275
SER A 272
None
None
None
OMT  A2473 ( 3.8A)
0.91A 5m8rC-2vdcA:
undetectable
5m8rC-2vdcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A 372
GLY A   4
GLY A 365
ALA A 229
GLN A 223
None
None
None
None
OMT  A2473 (-4.3A)
0.97A 5x7fA-2vdcA:
undetectable
5x7fA-2vdcA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A 372
GLY A   4
GLY A 366
ALA A 229
GLN A 223
None
None
None
None
OMT  A2473 (-4.3A)
0.72A 5x7fA-2vdcA:
undetectable
5x7fA-2vdcA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5o84 GLUTATHIONE
S-TRANSFERASE U23

(Arabidopsis
thaliana)
4 / 5 PHE A 160
PHE A 157
LEU A 182
PHE A 179
OMT  A  14 ( 3.8A)
None
None
None
1.34A 5xdqC-5o84A:
undetectable
5xdqJ-5o84A:
undetectable
5xdqC-5o84A:
17.56
5xdqJ-5o84A:
16.51