SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 8 THR A 163
PHE A 239
MET A 217
LEU A 173
 OMP  A 500 ( 4.2A)
None
None
None
 1.09A 1lhvA-2za1A:
undetectable		 1lhvA-2za1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		3 / 3 LYS A 193
ILE A 261
THR A 163
 None
None
OMP  A 500 ( 4.2A)
 0.65A 1rx3A-2za1A:
undetectable		 1rx3A-2za1A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		3 / 3 LYS A 193
ILE A 261
THR A 163
 None
None
OMP  A 500 ( 4.2A)
 0.65A 4gh8A-2za1A:
undetectable		 4gh8A-2za1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2wns OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ASP A 154
SER A 128
GLY A 159
ALA A 149
 None
OMP  A 450 (-2.5A)
None
None
 0.81A 4m48A-2wnsA:
undetectable		 4m48A-2wnsA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.16A 4w5qA-2za1A:
undetectable		 4w5qA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.21A 4w5tA-2za1A:
undetectable		 4w5tA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.20A 4z4dA-2za1A:
undetectable		 4z4dA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 7 ILE A 296
GLY A 293
PHE A  88
ASP A  28
 None
OMP  A 500 (-3.6A)
None
None
 1.01A 5hieA-2za1A:
undetectable		 5hieA-2za1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  40
VAL A 133
THR A 135
LEU A 202
 None
OMP  A 450 (-4.4A)
OMP  A 450 (-2.8A)
None
 0.94A 5tudD-2przA:
undetectable		 5tudD-2przA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.16A 6cbdA-2za1A:
undetectable		 6cbdA-2za1A:
14.80