SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OMN'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.04A 1pxxC-1sezA:
undetectable
1pxxC-1sezA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 THR A 368
GLY A 394
GLY A 395
GLY A 178
SER A 335
None
None
None
OMN  A 601 (-3.6A)
None
1.19A 1wg8A-1sezA:
3.0
1wg8A-1sezA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A 334
ALA A 174
LEU A 184
LEU A 473
PHE A 392
OMN  A 601 (-4.7A)
None
None
None
OMN  A 601 (-3.6A)
1.48A 2oaxC-1sezA:
undetectable
2oaxC-1sezA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 LEU A 334
GLY A 395
LEU A 401
ASP A 180
LEU A 369
OMN  A 601 (-4.7A)
None
None
None
OMN  A 601 (-3.7A)
1.00A 3cjtC-1sezA:
3.9
3cjtC-1sezA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1A-1sezA:
undetectable
3ln1A-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1B-1sezA:
undetectable
3ln1B-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1C-1sezA:
undetectable
3ln1C-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.05A 3ln1D-1sezA:
undetectable
3ln1D-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 337
SER A 335
LEU A 409
ALA A 438
GLY A 370
None
None
None
FAD  A 600 (-3.7A)
OMN  A 601 (-3.5A)
0.98A 3ln1D-1sezA:
undetectable
3ln1D-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.09A 3nt1A-1sezA:
0.0
3nt1A-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.09A 3nt1B-1sezA:
0.0
3nt1B-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.03A 3pghD-1sezA:
0.0
3pghD-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 3rr3A-1sezA:
undetectable
3rr3A-1sezA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 4coxA-1sezA:
undetectable
4coxA-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.07A 4coxB-1sezA:
undetectable
4coxB-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.07A 4coxC-1sezA:
undetectable
4coxC-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.07A 4coxD-1sezA:
undetectable
4coxD-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 4rrwA-1sezA:
undetectable
4rrwA-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 4rrzA-1sezA:
undetectable
4rrzA-1sezA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 5ikqA-1sezA:
undetectable
5ikqA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.04A 5ikrB-1sezA:
0.0
5ikrB-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 5jvzA-1sezA:
0.0
5jvzA-1sezA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.06A 5kirA-1sezA:
undetectable
5kirA-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 VAL A 332
VAL A 173
GLY A 175
ALA A 174
LEU A 369
None
None
OMN  A 601 (-3.6A)
None
OMN  A 601 (-3.7A)
1.08A 5kirB-1sezA:
undetectable
5kirB-1sezA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
4 / 6 PRO A 181
LEU A 356
PHE A 172
LEU A 168
None
OMN  A 601 ( 4.7A)
TON  A 603 (-3.9A)
TON  A 603 (-4.5A)
1.21A 5tl8A-1sezA:
undetectable
5tl8A-1sezA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 12 GLY A 175
THR A 176
CYH A 177
GLY A 178
LEU A 420
OMN  A 601 (-3.6A)
None
None
OMN  A 601 (-3.6A)
None
0.96A 5ybbA-1sezA:
undetectable
5ybbA-1sezA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum)
5 / 8 GLY A 370
PHE A 392
VAL A 337
GLY A 179
ALA A 438
OMN  A 601 (-3.5A)
OMN  A 601 (-3.6A)
None
None
FAD  A 600 (-3.7A)
1.43A 6hu9H-1sezA:
undetectable
6hu9e-1sezA:
undetectable
6hu9H-1sezA:
11.36
6hu9e-1sezA:
14.97