SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OLC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 146
VAL A  62
ILE A 119
ILE A 113
ILE A  66
 None
None
None
OLC  A 503 ( 4.5A)
None
 0.75A 1c6zB-3wbnA:
undetectable		 1c6zB-3wbnA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 11 CYH A 365
SER A 116
LEU A 117
VAL A 152
ILE A 159
 OLC  A2005 (-3.5A)
None
None
None
OLC  A2004 ( 4.3A)
 1.32A 1ee2B-3vw7A:
undetectable		 1ee2B-3vw7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 8 LEU A 377
ALA A 393
PHE A 381
VAL A 390
 None
None
OLC  A 531 ( 4.4A)
None
 0.88A 1epbB-5t77A:
undetectable		 1epbB-5t77A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 12 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 1.08A 1fe2A-5y79A:
undetectable		 1fe2A-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 12 LEU A 109
PHE A 104
ALA A 341
GLY A 347
LEU A 348
 None
OLC  A 402 (-4.6A)
OLC  A 402 (-3.7A)
None
None
 0.97A 1fe2A-6barA:
undetectable		 1fe2A-6barA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 12 TYR A  99
LEU A 250
SER A  18
LEU A 243
ILE A 274
 OLC  A 301 ( 4.8A)
None
None
None
None
 1.39A 1fmlA-5i20A:
undetectable		 1fmlA-5i20A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 7 PHE A 364
THR A 224
VAL A 227
ALA A 367
 OLC  A 529 (-3.1A)
OLC  A 539 ( 2.5A)
OLC  A 530 ( 4.5A)
OLC  A 530 (-2.9A)
 1.09A 1fo4B-5t77A:
undetectable		 1fo4B-5t77A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 GLY A 146
VAL A  62
ILE A 119
ILE A 113
ILE A  66
 None
None
None
OLC  A 503 ( 4.5A)
None
 0.96A 1hpvA-3wbnA:
undetectable		 1hpvA-3wbnA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 12 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 0.91A 1igxA-5y79A:
undetectable		 1igxA-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 12 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 1.01A 1igxA-5y79A:
undetectable		 1igxA-5y79A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5jsi BACTERIORHODOPSIN
(Candidatus
Actinomarina
minuta) 		5 / 12 THR A 193
TYR A 192
ILE A 109
TYR A 113
TYR A  64
 None
None
LYR  A 200 ( 4.8A)
OLC  A 322 ( 3.7A)
None
 1.20A 1jtxA-5jsiA:
2.0		 1jtxA-5jsiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 ASP A  90
GLY A 134
SER A 133
ALA A  89
ALA A  98
 None
OLC  A 502 ( 4.5A)
None
None
None
 1.31A 1nw5A-6exsA:
undetectable		 1nw5A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.07A 1o76B-3wbnA:
undetectable		 1o76B-3wbnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 PRO A  50
LEU A  49
HIS A  12
ARG A  57
 None
None
OLC  A 605 (-4.1A)
None
 1.26A 1oafA-5n6mA:
undetectable		 1oafA-5n6mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ASN A 154
GLY A  72
SER A 205
GLY A 146
ILE A 149
 OLC  A 505 ( 3.6A)
None
OLC  A 505 (-3.2A)
None
None
 1.18A 1q8jB-3wbnA:
undetectable		 1q8jB-3wbnA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 266
PHE A 270
ILE A 229
ILE A 136
ILE A 172
 None
None
None
None
OLC  A1201 (-4.3A)
 1.05A 1r5lA-4rwaA:
undetectable		 1r5lA-4rwaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.88A 1rxcB-3wbnA:
undetectable		 1rxcB-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.90A 1rxcC-3wbnA:
undetectable		 1rxcC-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.86A 1rxcD-3wbnA:
undetectable		 1rxcD-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.88A 1rxcE-3wbnA:
undetectable		 1rxcE-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.89A 1rxcF-3wbnA:
undetectable		 1rxcF-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.89A 1rxcI-3wbnA:
undetectable		 1rxcI-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.88A 1rxcK-3wbnA:
undetectable		 1rxcK-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.88A 1rxcL-3wbnA:
undetectable		 1rxcL-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4uc3 TRANSLOCATOR PROTEIN
TSPO
(Rhodobacter
sphaeroides) 		4 / 4 LEU A 133
VAL A 130
ILE A 134
TRP A 108
 None
None
YZY  A 203 ( 4.9A)
OLC  A 202 (-3.7A)
 1.09A 1s9qB-4uc3A:
undetectable		 1s9qB-4uc3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 VAL A 139
VAL A 195
TYR A 187
CYH A 184
 OLC  A2008 (-4.6A)
None
None
None
 1.26A 1t46A-3vw7A:
undetectable		 1t46A-3vw7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.04A 1t85A-3wbnA:
undetectable		 1t85A-3wbnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A  81
PHE A  79
LEU A 137
VAL A 171
VAL A 172
 None
OLC  A1216 ( 4.6A)
None
None
None
 0.85A 1ukbA-6aqfA:
undetectable		 1ukbA-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.05A 1uyuB-3wbnA:
undetectable		 1uyuB-3wbnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4p79 CLAUDIN-15
(Mus
musculus) 		5 / 12 ALA A 127
GLY A 131
ILE A  86
ILE A 173
SER A 172
 None
None
OLC  A 201 ( 4.5A)
None
None
 1.05A 1ve3A-4p79A:
undetectable		 1ve3A-4p79A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 GLY A 132
ILE A  88
ALA A  86
ILE A  78
SER A  81
 None
None
None
None
OLC  A 502 (-4.5A)
 1.01A 1ve3A-6exsA:
undetectable		 1ve3A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
C-C MOTIF CHEMOKINE
5
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 5 ALA A  91
ALA A  87
TYR A  89
GLN B   8
 OLC  A1106 ( 4.2A)
OLC  A1106 ( 4.4A)
None
None
 1.13A 1xl6A-5uiwA:
undetectable
1xl6B-5uiwA:
undetectable		 1xl6A-5uiwA:
20.89
1xl6B-5uiwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.03A 1yrcA-3wbnA:
undetectable		 1yrcA-3wbnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5dir LIPOPROTEIN SIGNAL
PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A  30
ILE A  40
VAL A  42
PHE A  47
 OLC  A 207 ( 4.8A)
OLC  A 207 (-4.6A)
OLC  A 208 ( 4.3A)
None
 0.83A 2cizA-5dirA:
undetectable		 2cizA-5dirA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 7 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.07A 2eimC-4xt1A:
0.0
2eimJ-4xt1A:
undetectable		 2eimC-4xt1A:
21.81
2eimJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.02A 2feuB-3wbnA:
undetectable		 2feuB-3wbnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4xnv P2Y PURINOCEPTOR 1,
RUBREDOXIN, P2Y
PURINOCEPTOR 1
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 10 PHE A 298
VAL A 302
ARG A 285
ALA A 286
PHE A 290
 Y01  A1103 ( 4.9A)
Y01  A1103 ( 4.3A)
OLC  A1112 (-4.8A)
None
OLC  A1106 ( 4.9A)
 1.04A 2jj8D-4xnvA:
undetectable		 2jj8D-4xnvA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 TYR A 206
SER A 205
TYR A 209
ARG A 210
 UNL  A 409 ( 4.7A)
OLC  A 406 ( 4.0A)
OLC  A 407 ( 3.7A)
OLC  A 407 (-4.8A)
 0.92A 2kqeA-4xt1A:
undetectable		 2kqeA-4xt1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 12 SER A 178
THR A 182
ASN A 340
ALA A 149
THR A 153
 None
None
3PG  A 516 ( 4.7A)
OLC  A 504 ( 3.9A)
OLC  A 504 (-4.1A)
 1.25A 2nniA-5y79A:
1.8		 2nniA-5y79A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 12 ILE A 390
PHE A 199
VAL A 364
GLU A 245
THR A 244
 OLC  A 505 ( 3.9A)
None
OLC  A 505 ( 4.2A)
OLC  A 505 (-3.7A)
None
 1.04A 2vn0A-5y79A:
undetectable		 2vn0A-5y79A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 7 VAL A 242
TYR A  99
TYR A 245
ILE A 105
 None
OLC  A 301 ( 4.8A)
None
None
 1.28A 2xz5B-5i20A:
undetectable
2xz5E-5i20A:
undetectable		 2xz5B-5i20A:
19.67
2xz5E-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 8 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.27A 2xz5A-5i20A:
undetectable
2xz5C-5i20A:
undetectable		 2xz5A-5i20A:
19.67
2xz5C-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 8 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.28A 2xz5C-5i20A:
undetectable
2xz5D-5i20A:
undetectable		 2xz5C-5i20A:
19.67
2xz5D-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 7 ILE A 105
VAL A 242
TYR A  99
TYR A 245
 None
None
OLC  A 301 ( 4.8A)
None
 1.27A 2xz5D-5i20A:
undetectable
2xz5E-5i20A:
undetectable		 2xz5D-5i20A:
19.67
2xz5E-5i20A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		3 / 3 PHE A 468
ASN A 695
PHE A 470
 OLC  A 803 (-3.9A)
None
OLC  A 803 ( 4.2A)
 1.01A 2zbuD-5xapA:
undetectable		 2zbuD-5xapA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		4 / 8 MET A 289
ALA A 288
TYR A 277
TYR A 436
 None
None
OLC  A 501 (-3.6A)
None
 0.80A 2zm9A-4z3nA:
undetectable		 2zm9A-4z3nA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.05A 2zwtA-3wbnA:
undetectable		 2zwtA-3wbnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.04A 2zwuA-3wbnA:
undetectable		 2zwuA-3wbnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5zkq PLATELET-ACTIVATING
FACTOR
RECEPTOR,ENDOLYSIN,E
NDOLYSIN,PLATELET-AC
TIVATING FACTOR
RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 ILE A  99
ILE A  25
TYR A  22
PHE A  98
 None
None
9EU  A 501 (-4.7A)
OLC  A 502 ( 4.8A)
 0.75A 3adsA-5zkqA:
undetectable		 3adsA-5zkqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 9 LEU A 105
ILE A 108
GLY A 109
LEU A 101
GLU A  36
 None
None
None
OLC  A 512 ( 4.0A)
None
 1.04A 3ai9X-6exsA:
undetectable		 3ai9X-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 0.96A 3bxoA-4z3nA:
undetectable		 3bxoA-4z3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 1.03A 3bxoB-4z3nA:
undetectable		 3bxoB-4z3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 PHE A  69
LEU A 338
GLY A 343
GLY A 339
ALA A 346
 None
None
OLC  A 806 (-3.9A)
None
None
 1.14A 3dh0B-5xapA:
undetectable		 3dh0B-5xapA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 10 CYH A 365
ILE A 366
ILE A 362
VAL A 108
GLY A 111
 OLC  A2005 (-3.5A)
None
OLC  A2005 ( 4.4A)
None
OLC  A2005 ( 4.6A)
 1.12A 3em0A-3vw7A:
undetectable		 3em0A-3vw7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 10 CYH A 365
ILE A 366
VAL A 108
GLY A 111
LEU A 119
 OLC  A2005 (-3.5A)
None
None
OLC  A2005 ( 4.6A)
None
 1.23A 3em0A-3vw7A:
undetectable		 3em0A-3vw7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		3 / 3 TYR A 397
TYR A 320
ILE A 390
 OLC  A 505 ( 3.7A)
None
None
 0.84A 3eteA-6exsA:
undetectable
3eteB-6exsA:
undetectable		 3eteA-6exsA:
10.71
3eteB-6exsA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.00A 3fwfA-3wbnA:
undetectable		 3fwfA-3wbnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.02A 3fwfB-3wbnA:
undetectable		 3fwfB-3wbnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.04A 3fwjA-3wbnA:
undetectable		 3fwjA-3wbnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		3 / 3 MET A 132
MET A 141
PHE A 222
 None
OLC  A1201 (-3.5A)
None
 1.02A 3gn8A-4rwaA:
undetectable		 3gn8A-4rwaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 12 PHE A 272
GLY A 211
ALA A 212
SER A 215
LEU A 219
 OLC  A 507 (-4.8A)
None
None
None
None
 0.98A 3hs6B-5y79A:
undetectable		 3hs6B-5y79A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 8 GLU A  36
GLU A  33
SER A  81
ILE A 131
 None
None
OLC  A 502 (-4.5A)
None
 1.08A 3jz0B-6exsA:
2.6		 3jz0B-6exsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 PHE A  45
TYR A  50
LEU A 158
 None
OLC  A 201 (-4.3A)
None
 0.73A 3keeB-4p79A:
undetectable		 3keeB-4p79A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		5 / 10 GLY A 185
ILE A 228
PHE A 237
PHE A 178
GLY A 163
 LYR  A 257 ( 4.2A)
None
OLC  A1101 (-3.4A)
OLC  A1101 ( 4.0A)
LYR  A 257 ( 3.7A)
 0.99A 3ko0R-6eidA:
undetectable
3ko0T-6eidA:
0.6		 3ko0R-6eidA:
18.81
3ko0T-6eidA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		5 / 10 GLY A 185
PHE A 237
PHE A 178
GLY A 163
PHE A 230
 LYR  A 257 ( 4.2A)
OLC  A1101 (-3.4A)
OLC  A1101 ( 4.0A)
LYR  A 257 ( 3.7A)
LYR  A 257 ( 4.7A)
 1.48A 3ko0R-6eidA:
undetectable
3ko0T-6eidA:
0.6		 3ko0R-6eidA:
18.81
3ko0T-6eidA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.87A 3kvvA-3wbnA:
undetectable		 3kvvA-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.86A 3kvvB-3wbnA:
undetectable		 3kvvB-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.89A 3kvvC-3wbnA:
undetectable		 3kvvC-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.84A 3kvvD-3wbnA:
undetectable		 3kvvD-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.89A 3kvvE-3wbnA:
undetectable		 3kvvE-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.90A 3kvvF-3wbnA:
undetectable		 3kvvF-3wbnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.01A 3l63A-3wbnA:
undetectable		 3l63A-3wbnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 101
LEU A 160
ILE A 213
ALA A 214
THR A 223
 OLC  A 502 (-4.4A)
None
None
OLC  A 502 ( 4.2A)
None
 1.14A 3mdvA-3wbnA:
undetectable		 3mdvA-3wbnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 LEU A 348
LEU A 723
ILE A 296
GLY A 299
ALA A 300
 None
None
OLC  A 807 (-4.4A)
OLC  A 807 ( 4.5A)
OLC  A 807 ( 3.8A)
 0.78A 3n8zB-5xapA:
undetectable		 3n8zB-5xapA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 314
GLY A 260
GLY A  93
SER A  94
ALA A  83
 None
None
None
None
OLC  A 507 ( 3.9A)
 1.14A 3ou6B-4z3nA:
undetectable		 3ou6B-4z3nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 314
GLY A 260
GLY A  93
SER A  94
ALA A  83
 None
None
None
None
OLC  A 507 ( 3.9A)
 1.14A 3ou7B-4z3nA:
undetectable		 3ou7B-4z3nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 1.05A 3pfgA-4z3nA:
undetectable		 3pfgA-4z3nA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 10 ILE A 243
ILE A  88
THR A  93
ILE A 106
ILE A  78
 None
None
OLC  A 512 (-4.7A)
None
None
 1.19A 3prsA-6exsA:
undetectable		 3prsA-6exsA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 112
TYR A 113
SER A 116
TRP A 164
TYR A 443
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 4.0A)
0HK  A1201 (-4.5A)
 0.90A 3rzeA-5dsgA:
31.2		 3rzeA-5dsgA:
48.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 PHE A  45
TYR A  50
LEU A 158
 None
OLC  A 201 (-4.3A)
None
 0.65A 3sueB-4p79A:
undetectable		 3sueB-4p79A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		3 / 3 GLN A 375
PHE A 292
TYR A 277
 OLC  A 501 ( 4.0A)
OLC  A 501 ( 4.5A)
OLC  A 501 (-3.6A)
 0.86A 3ucjB-4z3nA:
undetectable		 3ucjB-4z3nA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		3 / 3 GLN A 375
PHE A 292
TYR A 277
 OLC  A 501 ( 4.0A)
OLC  A 501 ( 4.5A)
OLC  A 501 (-3.6A)
 0.90A 3ucjA-4z3nA:
undetectable		 3ucjA-4z3nA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 5 LEU A 333
LEU A 332
LEU A 340
SER A 341
 VPX  A2001 (-4.9A)
OLC  A2007 (-4.6A)
VPX  A2001 ( 4.7A)
None
 0.71A 3vhuA-3vw7A:
undetectable		 3vhuA-3vw7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.02A 3wrhA-3wbnA:
undetectable		 3wrhA-3wbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.03A 3wrjA-3wbnA:
undetectable		 3wrjA-3wbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.02A 3wrlA-3wbnA:
undetectable		 3wrlA-3wbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.03A 3wrlE-3wbnA:
undetectable		 3wrlE-3wbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.03A 3wrmA-3wbnA:
undetectable		 3wrmA-3wbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.04A 3wrmF-3wbnA:
undetectable		 3wrmF-3wbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		3 / 3 TRP A 101
VAL A 161
TRP A 163
 OLC  A 301 (-3.8A)
None
OLC  A 301 (-3.8A)
 1.50A 3zq8A-5i20A:
undetectable
3zq8B-5i20A:
undetectable		 3zq8A-5i20A:
5.70
3zq8B-5i20A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 246
GLY A 248
ILE A 252
LEU A  55
 None
OLC  A1102 ( 3.7A)
None
None
 0.73A 4ac9C-6eidA:
undetectable		 4ac9C-6eidA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6eid ARCHAEAL-TYPE OPSIN
2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 246
GLY A 248
ILE A 252
LEU A  55
 None
OLC  A1102 ( 3.7A)
None
None
 0.78A 4acaC-6eidA:
undetectable		 4acaC-6eidA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		12 / 12 ASP A 112
TYR A 113
SER A 116
ASN A 117
TRP A 164
THR A 196
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 3.6A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.62A 4dajA-5dsgA:
42.2		 4dajA-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 ASP A 112
TYR A 113
THR A 199
TRP A 413
ASN A 417
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
 1.41A 4dajA-5dsgA:
42.2		 4dajA-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A 113
THR A 199
TRP A 413
TYR A 416
CYH A 442
 0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-3.6A)
 1.46A 4dajA-5dsgA:
42.2		 4dajA-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		11 / 12 ASP A 112
TYR A 113
SER A 116
THR A 196
THR A 199
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.64A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		11 / 12 ASP A 112
TYR A 113
TRP A 164
THR A 196
THR A 199
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.51A 4dajB-5dsgA:
42.1		 4dajB-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		11 / 12 ASP A 112
TYR A 113
ASN A 117
TRP A 164
THR A 196
THR A 199
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 ( 3.6A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.55A 4dajC-5dsgA:
41.9		 4dajC-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		11 / 12 ASP A 112
TYR A 113
SER A 116
ASN A 117
THR A 196
THR A 199
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 3.6A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.67A 4dajC-5dsgA:
41.9		 4dajC-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 ASP A 112
TYR A 113
THR A 199
TRP A 413
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.39A 4dajC-5dsgA:
41.9		 4dajC-5dsgA:
66.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAJ_D_0HKD2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		12 / 12 ASP A 112
TYR A 113
SER A 116
ASN A 117
TRP A 164
THR A 196
THR A 199
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 3.6A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.57A 4dajD-5dsgA:
42.1		 4dajD-5dsgA:
66.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.87A 4e1vA-3wbnA:
undetectable		 4e1vA-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.90A 4e1vB-3wbnA:
undetectable		 4e1vB-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.89A 4e1vC-3wbnA:
undetectable		 4e1vC-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.87A 4e1vD-3wbnA:
undetectable		 4e1vD-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.91A 4e1vE-3wbnA:
undetectable		 4e1vE-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.89A 4e1vF-3wbnA:
undetectable		 4e1vF-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.90A 4e1vG-3wbnA:
undetectable		 4e1vG-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLY A 108
MET A 115
ILE A 150
VAL A 151
 None
None
OLC  A 505 ( 4.4A)
None
 0.87A 4e1vH-3wbnA:
undetectable		 4e1vH-3wbnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 7 GLY A 355
THR A 359
ILE A 337
LEU A 341
 None
None
OLC  A 807 (-4.5A)
None
 0.88A 4ejjD-5xapA:
undetectable		 4ejjD-5xapA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 11 TYR A  78
GLY A  71
TYR A 166
TRP A 163
TYR A 226
 OLC  A 301 (-4.3A)
None
None
OLC  A 301 (-3.8A)
None
 1.47A 4ey7A-5i20A:
undetectable		 4ey7A-5i20A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 11 TYR A  78
GLY A  71
TYR A 166
TRP A 163
TYR A 226
 OLC  A 301 (-4.3A)
None
None
OLC  A 301 (-3.8A)
None
 1.48A 4ey7B-5i20A:
undetectable		 4ey7B-5i20A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ASN A 153
PHE A  63
ILE A  66
PHE A  59
 OLC  A 505 ( 4.2A)
None
None
None
 0.91A 4fglC-3wbnA:
undetectable		 4fglC-3wbnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 LEU A 229
ALA A 225
LEU A 191
THR A 222
 OLC  A2010 (-4.2A)
OLC  A2010 ( 3.8A)
OLC  A2010 ( 4.5A)
OLC  A2010 (-3.7A)
 1.00A 4ikiB-3vw7A:
undetectable		 4ikiB-3vw7A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 9 LEU A 156
ILE A 163
ILE A 160
PHE A  23
GLY A  21
 OLC  A 527 ( 4.5A)
None
OLC  A 527 ( 4.7A)
OLC  A 536 (-3.3A)
None
 1.08A 4kukA-5t77A:
undetectable		 4kukA-5t77A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 0.99A 4l4eA-3wbnA:
undetectable		 4l4eA-3wbnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.00A 4l4fA-3wbnA:
undetectable		 4l4fA-3wbnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 1.05A 4l4gA-3wbnA:
undetectable		 4l4gA-3wbnA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		6 / 7 TYR A  89
GLN A 194
THR A 195
LEU A 255
THR A 259
THR A 284
 None
None
PCA  B   0 ( 4.3A)
None
None
OLC  A1107 ( 4.3A)
 0.63A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 7 TYR A  89
THR A 195
THR A 259
THR A 284
MET A 287
 None
PCA  B   0 ( 4.3A)
None
OLC  A1107 ( 4.3A)
None
 0.99A 4mbsA-5uiwA:
39.8		 4mbsA-5uiwA:
99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 5 TYR A  89
THR A 195
LEU A 255
THR A 284
 None
PCA  B   0 ( 4.3A)
None
OLC  A1107 ( 4.3A)
 0.62A 4mbsB-5uiwA:
41.1		 4mbsB-5uiwA:
99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 12 ILE A 160
GLY A 183
GLY A 187
ARG A  24
LEU A 171
 OLC  A 527 ( 4.7A)
OLC  A 525 ( 3.3A)
None
CL  A 501 ( 4.8A)
OLC  A 525 ( 3.9A)
 1.11A 4mwzA-5t77A:
undetectable		 4mwzA-5t77A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 GLY A 146
VAL A  62
ILE A 119
ILE A 113
ILE A  66
 None
None
None
OLC  A 503 ( 4.5A)
None
 0.96A 4njvC-3wbnA:
undetectable		 4njvC-3wbnA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		3 / 3 LEU A 227
MET A 143
TYR A 234
 None
OLC  A1207 ( 3.9A)
None
 0.51A 4p6xG-6bqhA:
undetectable		 4p6xG-6bqhA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qvmK-6barA:
undetectable
4qvmL-6barA:
undetectable		 4qvmK-6barA:
18.27
4qvmL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qvpK-6barA:
undetectable
4qvpL-6barA:
undetectable		 4qvpK-6barA:
17.26
4qvpL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qvpY-6barA:
undetectable
4qvpZ-6barA:
undetectable		 4qvpY-6barA:
17.26
4qvpZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qvwK-6barA:
undetectable
4qvwL-6barA:
undetectable		 4qvwK-6barA:
17.59
4qvwL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 THR A 328
THR A 342
GLY A 335
GLY A 336
SER A 337
 None
None
None
OLC  A 402 ( 4.7A)
OLC  A 402 ( 4.6A)
 1.09A 4qvwK-6barA:
undetectable
4qvwL-6barA:
undetectable		 4qvwK-6barA:
17.59
4qvwL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qvwY-6barA:
undetectable
4qvwZ-6barA:
undetectable		 4qvwY-6barA:
17.59
4qvwZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 11 THR A 328
THR A 342
GLY A 335
GLY A 336
SER A 337
 None
None
None
OLC  A 402 ( 4.7A)
OLC  A 402 ( 4.6A)
 1.09A 4qvwY-6barA:
undetectable
4qvwZ-6barA:
undetectable		 4qvwY-6barA:
17.59
4qvwZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qw1Y-6barA:
undetectable
4qw1Z-6barA:
undetectable		 4qw1Y-6barA:
17.59
4qw1Z-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.05A 4qw3K-6barA:
undetectable
4qw3L-6barA:
undetectable		 4qw3K-6barA:
17.26
4qw3L-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 10 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 4qw3Y-6barA:
undetectable
4qw3Z-6barA:
undetectable		 4qw3Y-6barA:
17.26
4qw3Z-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.14A 4qwuK-6barA:
undetectable
4qwuL-6barA:
undetectable		 4qwuK-6barA:
17.77
4qwuL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.14A 4qwuY-6barA:
undetectable
4qwuZ-6barA:
undetectable		 4qwuY-6barA:
17.77
4qwuZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 7 ALA A 246
GLY A 277
ALA A 278
THR A 282
 None
None
None
OLC  A 302 ( 4.4A)
 0.81A 4r1zB-5i20A:
undetectable		 4r1zB-5i20A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		5 / 9 ALA A 246
GLY A 277
ALA A 278
THR A 282
ILE A  14
 None
None
None
OLC  A 302 ( 4.4A)
None
 0.93A 4r21B-5i20A:
undetectable		 4r21B-5i20A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		3 / 3 ARG A 327
GLU A 245
TYR A 323
 None
None
OLC  A 503 (-3.7A)
 0.94A 4r29D-6f34A:
0.9		 4r29D-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4n4w CYTOCHROME
B(562),SMOOTHENED
HOMOLOG
(Shigella
flexneri;
Homo
sapiens) 		5 / 12 TYR A 262
HIS A 361
CYH A 273
ALA A 272
ILE A 266
 None
OLC  A 609 (-3.7A)
None
None
None
 1.40A 4rp9A-4n4wA:
undetectable		 4rp9A-4n4wA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 424
VAL A 435
GLY A 438
ALA A 439
SER A 417
 None
None
None
OLC  A 501 (-3.3A)
OLC  A 501 (-3.4A)
 1.10A 4rrwC-4z3nA:
undetectable		 4rrwC-4z3nA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 LEU A 424
VAL A 435
GLY A 438
ALA A 439
SER A 417
 None
None
None
OLC  A 501 (-3.3A)
OLC  A 501 (-3.4A)
 1.10A 4rrzC-4z3nA:
undetectable		 4rrzC-4z3nA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 ASP A 112
TYR A 113
THR A 199
ALA A 203
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.38A 4u14A-5dsgA:
41.2		 4u14A-5dsgA:
67.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		8 / 12 ILE A  81
ASP A 112
TYR A 113
THR A 199
TRP A 413
ASN A 417
TYR A 439
CYH A 442
 None
0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.45A 4u14A-5dsgA:
41.2		 4u14A-5dsgA:
67.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		11 / 12 ILE A  81
ASP A 112
TYR A 113
TRP A 164
THR A 196
ALA A 200
ALA A 203
TRP A 413
ASN A 417
TYR A 439
CYH A 442
 None
0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.64A 4u14A-5dsgA:
41.2		 4u14A-5dsgA:
67.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 4 ASN A 117
LEU A 190
PHE A 204
TYR A 416
 OLC  A1208 ( 3.6A)
P6G  A1205 (-4.6A)
None
0HK  A1201 (-4.2A)
 0.31A 4u14A-5dsgA:
41.2		 4u14A-5dsgA:
67.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		12 / 12 ASP A 112
TYR A 113
SER A 116
TRP A 164
THR A 196
THR A 199
ALA A 200
ALA A 203
TRP A 413
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.44A 4u15A-5dsgA:
43.6		 4u15A-5dsgA:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 112
TYR A 113
THR A 199
ALA A 203
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.44A 4u15A-5dsgA:
43.6		 4u15A-5dsgA:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A 113
TRP A 164
TRP A 413
TYR A 416
CYH A 442
 0HK  A1201 ( 3.2A)
OLC  A1208 ( 4.0A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-3.6A)
 1.50A 4u15A-5dsgA:
43.6		 4u15A-5dsgA:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 ASN A 117
PHE A 204
TYR A 416
 OLC  A1208 ( 3.6A)
None
0HK  A1201 (-4.2A)
 0.11A 4u15A-5dsgA:
43.6		 4u15A-5dsgA:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		12 / 12 ASP A 112
TYR A 113
SER A 116
THR A 196
THR A 199
ALA A 200
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.48A 4u15B-5dsgA:
44.9		 4u15B-5dsgA:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 ASP A 112
TYR A 113
THR A 199
ALA A 203
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
OLC  A1208 (-4.4A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.38A 4u15B-5dsgA:
44.9		 4u15B-5dsgA:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U15_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 4 ASN A 117
TRP A 164
LEU A 190
PHE A 204
 OLC  A1208 ( 3.6A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
None
 0.29A 4u15B-5dsgA:
44.9		 4u15B-5dsgA:
75.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		3 / 3 LYS A 128
ARG A 363
VAL A 202
 None
3PG  A 516 (-2.9A)
OLC  A 505 (-4.9A)
 0.89A 4x3uA-5y79A:
undetectable
4x3uB-5y79A:
undetectable		 4x3uA-5y79A:
8.81
4x3uB-5y79A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		4 / 4 GLY A 299
VAL A 357
PHE A 311
ILE A 307
 OLC  A 807 ( 4.5A)
None
None
None
 1.10A 4xv2B-5xapA:
undetectable		 4xv2B-5xapA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  40
TYR A  43
PRO A 186
 None
None
OLC  A 606 (-4.4A)
 0.58A 4zdyA-5n6mA:
undetectable		 4zdyA-5n6mA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ALA A  40
TYR A  43
HIS A 191
PRO A 186
 None
None
None
OLC  A 606 (-4.4A)
 1.16A 4ze2A-5n6mA:
undetectable		 4ze2A-5n6mA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		4 / 5 GLU A 207
THR A 360
THR A 230
HIS A 224
 None
None
OLC  A 511 ( 4.8A)
None
 1.23A 5axaA-5y79A:
undetectable		 5axaA-5y79A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		4 / 5 GLU A 207
THR A 360
THR A 230
HIS A 224
 None
None
OLC  A 511 ( 4.8A)
None
 1.20A 5axaC-5y79A:
undetectable		 5axaC-5y79A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		4 / 6 THR A 393
TYR A 396
THR A 230
SER A 397
 None
None
OLC  A 511 ( 4.8A)
None
 1.39A 5b6iB-5y79A:
undetectable		 5b6iB-5y79A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5xap PROTEIN TRANSLOCASE
SUBUNIT SECD
(Deinococcus
radiodurans) 		5 / 12 GLY A 292
GLY A 288
THR A 510
ILE A 296
LEU A  76
 None
None
None
OLC  A 807 (-4.4A)
None
 1.16A 5bw4A-5xapA:
undetectable		 5bw4A-5xapA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 VAL A 106
GLY A  85
THR A 146
MET A  93
LEU A  90
 PO4  A 306 (-4.0A)
None
OLC  A 302 ( 3.9A)
None
OLC  A 305 ( 4.9A)
 1.14A 5byjA-5xj6A:
undetectable		 5byjA-5xj6A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		11 / 12 ASP A 112
TYR A 113
SER A 116
TRP A 164
ALA A 200
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 4.0A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.38A 5cxvA-5dsgA:
42.1		 5cxvA-5dsgA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 THR A 196
THR A 199
PHE A 204
 P6G  A1205 (-4.6A)
OLC  A1208 (-4.4A)
None
 0.42A 5cxvA-5dsgA:
42.1		 5cxvA-5dsgA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 5d0xK-6barA:
undetectable
5d0xL-6barA:
undetectable		 5d0xK-6barA:
17.26
5d0xL-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6bar ROD SHAPE
DETERMINING PROTEIN
RODA
(Thermus
thermophilus) 		5 / 9 ALA A 341
THR A 342
ALA A 344
GLY A 335
GLY A 336
 OLC  A 402 (-3.7A)
None
OLC  A 402 ( 3.9A)
None
OLC  A 402 ( 4.7A)
 1.06A 5d0xY-6barA:
undetectable
5d0xZ-6barA:
undetectable		 5d0xY-6barA:
17.26
5d0xZ-6barA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 6f34 AMINO ACID
TRANSPORTER
(Geobacillus
kaustophilus) 		4 / 7 SER A  89
GLY A  90
TYR A 323
ALA A 238
 None
None
OLC  A 503 (-3.7A)
None
 0.93A 5e26A-6f34A:
undetectable
5e26B-6f34A:
undetectable		 5e26A-6f34A:
undetectable
5e26B-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 7 THR A 263
LEU A 255
VAL A 245
THR A 249
 None
OLC  A 513 (-4.2A)
None
None
 0.92A 5e4dA-6exsA:
undetectable
5e4dB-6exsA:
undetectable		 5e4dA-6exsA:
undetectable
5e4dB-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 GLY A 396
ASP A 326
ARG A 324
TYR A 320
 OLC  A 505 (-3.4A)
None
None
None
 1.08A 5iwuA-6exsA:
undetectable		 5iwuA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.16A 5iy5P-4xt1A:
0.0
5iy5W-4xt1A:
undetectable		 5iy5P-4xt1A:
20.78
5iy5W-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 SER A 360
GLY A 327
ASN A 330
ILE A 321
 None
OLC  A2007 (-3.6A)
None
None
 1.14A 5j4nA-3vw7A:
undetectable		 5j4nA-3vw7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 GLY A  76
SER A  78
ARG A 161
GLY A 158
 None
None
OLC  A 504 (-3.6A)
None
 1.03A 5kprA-3wbnA:
undetectable		 5kprA-3wbnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 6 GLU A 236
PHE A 268
THR A 271
TYR A 269
 None
None
OLC  A1206 (-4.8A)
None
 1.23A 5lrbA-5gliA:
undetectable		 5lrbA-5gliA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 LEU A  20
LEU A  24
TRP A  49
 None
OLC  A 201 (-4.0A)
OLC  A 201 (-4.2A)
 0.88A 5nwuA-4p79A:
undetectable		 5nwuA-4p79A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 207
TRP A 203
ARG A  24
GLY A  27
 OLC  A 508 ( 4.8A)
None
None
None
 0.91A 5o4yA-6exsA:
undetectable		 5o4yA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 207
TRP A 203
ARG A  24
GLY A  25
 OLC  A 508 ( 4.8A)
None
None
None
 1.05A 5o4yF-6exsA:
undetectable		 5o4yF-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 207
TRP A 203
ARG A  24
GLY A  27
 OLC  A 508 ( 4.8A)
None
None
None
 1.08A 5o4yF-6exsA:
undetectable		 5o4yF-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uh6C-5oonA:
undetectable		 5uh6C-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uhbC-5oonA:
1.1		 5uhbC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.42A 5uhcC-5oonA:
undetectable		 5uhcC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.47A 5uhdC-5oonA:
undetectable		 5uhdC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uhgC-5oonA:
undetectable		 5uhgC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 ILE A 147
LEU A 138
GLU A 153
ALA A 214
GLY A 212
 None
None
None
OLC  A 506 ( 3.9A)
None
 0.99A 5uxdB-4z3nA:
undetectable		 5uxdB-4z3nA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5xjj MULTI DRUG EFFLUX
TRANSPORTER
(Camelina
sativa) 		4 / 7 GLN A 459
GLY A 397
ILE A 401
GLN A 443
 OLC  A 501 ( 4.5A)
None
None
None
 1.06A 5vlmC-5xjjA:
undetectable		 5vlmC-5xjjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5xjj MULTI DRUG EFFLUX
TRANSPORTER
(Camelina
sativa) 		4 / 8 GLN A 459
GLY A 397
ILE A 401
GLN A 443
 OLC  A 501 ( 4.5A)
None
None
None
 1.05A 5vlmD-5xjjA:
undetectable		 5vlmD-5xjjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 202
LEU A 143
VAL A  45
ASP A  41
 OLC  A 505 ( 4.5A)
None
None
None
 0.98A 5wk9A-3wbnA:
undetectable		 5wk9A-3wbnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.17A 5x1fC-4xt1A:
0.0
5x1fJ-4xt1A:
undetectable		 5x1fC-4xt1A:
21.81
5x1fJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5i20 UNCHARACTERIZED
PROTEIN
(Starkeya
novella) 		4 / 8 PRO A 248
ALA A 125
THR A 132
ALA A  98
 None
None
None
OLC  A 301 ( 3.7A)
 0.95A 5x2tI-5i20A:
undetectable
5x2tJ-5i20A:
undetectable
5x2tK-5i20A:
undetectable
5x2tL-5i20A:
undetectable		 5x2tI-5i20A:
18.79
5x2tJ-5i20A:
21.67
5x2tK-5i20A:
18.79
5x2tL-5i20A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4e1t INVASIN
(Yersinia
pseudotuberculos
is) 		4 / 6 TYR A 294
GLU A 297
GLY A 270
GLY A 271
 None
None
None
OLC  A 412 ( 4.0A)
 0.96A 5x7pB-4e1tA:
undetectable		 5x7pB-4e1tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.19A 5xdxC-4xt1A:
0.0
5xdxJ-4xt1A:
undetectable		 5xdxC-4xt1A:
20.61
5xdxJ-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28
(Cytomegalovirus) 		4 / 5 LEU A 306
PHE A 309
LEU A 302
PHE A 293
 None
None
None
OLC  A 405 (-3.9A)
 1.16A 5xdxP-4xt1A:
0.0
5xdxW-4xt1A:
undetectable		 5xdxP-4xt1A:
20.61
5xdxW-4xt1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 5 ALA A 336
SER A 395
GLY A 340
TYR A 257
 OLC  A 535 ( 3.7A)
None
None
None
 1.18A 5yodD-5t77A:
undetectable		 5yodD-5t77A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 187
ARG A  47
GLY A  45
ARG A  57
 None
OLC  A 606 (-2.8A)
None
None
 1.20A 6az3P-5n6mA:
0.0		 6az3P-5n6mA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER
(Escherichia
coli) 		5 / 12 GLY A  80
ILE A 126
TYR A 155
LEU A 137
GLY A 130
 OLC  A 507 ( 3.8A)
None
None
None
None
 1.31A 6bp4B-4z3nA:
undetectable		 6bp4B-4z3nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 ARG A 232
LYS A 239
ARG A 313
 OLC  A1207 (-3.5A)
OLC  A1207 (-3.7A)
None
 1.31A 6c06D-5t1aA:
1.9		 6c06D-5t1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 156
ASN A 157
SER A  78
ARG A 161
 None
OLC  A 504 (-3.9A)
None
OLC  A 504 (-3.6A)
 1.08A 6dwdA-3wbnA:
undetectable
6dwdC-3wbnA:
undetectable		 6dwdA-3wbnA:
22.47
6dwdC-3wbnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 7 SER A 109
PHE A  39
GLY A 105
ALA A 104
 None
OLC  A 503 (-4.2A)
None
OLC  A 509 (-3.6A)
 0.74A 6dwnB-5aynA:
undetectable		 6dwnB-5aynA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 10 PHE A  78
LEU A  81
THR A  82
GLY A 106
ILE A 110
 None
OLC  A1103 ( 4.6A)
None
None
None
 1.11A 6ebpB-5uiwA:
2.0		 6ebpB-5uiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 10 PHE A  78
LEU A  81
THR A  82
GLY A 106
ILE A 110
 None
OLC  A1103 ( 4.6A)
None
None
None
 1.11A 6ebpC-5uiwA:
undetectable		 6ebpC-5uiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 10 PHE A  78
LEU A  81
THR A  82
GLY A 106
ILE A 110
 None
OLC  A1103 ( 4.6A)
None
None
None
 1.13A 6ebpD-5uiwA:
2.1		 6ebpD-5uiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR
(Galdieria
sulphuraria) 		5 / 11 THR A 387
VAL A 238
THR A 360
ILE A 361
VAL A 364
 OLC  A 505 (-3.8A)
OLC  A 501 ( 4.4A)
None
None
OLC  A 505 ( 4.2A)
 1.06A 6hcoA-5y79A:
undetectable
6hcoB-5y79A:
undetectable		 6hcoA-5y79A:
19.46
6hcoB-5y79A:
19.46