SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OLA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		9 / 10 ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
PHE A 135
 OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-4.3A)
 0.62A 1aqbA-2wq9A:
31.5		 1aqbA-2wq9A:
93.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  43
PHE A  77
MET A  88
HIS A 104
PHE A 135
 OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 (-4.3A)
 1.00A 1brpA-2wq9A:
32.2		 1brpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A  37
MET A  73
PHE A  45
LEU A  97
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.9A)
OLA  A1179 (-4.6A)
None
OLA  A1179 (-4.3A)
 1.29A 1brpA-2wq9A:
32.2		 1brpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		12 / 12 LEU A  37
PHE A  45
ALA A  57
MET A  73
GLY A  75
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 (-4.6A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 (-3.8A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-4.3A)
 0.39A 1brpA-2wq9A:
32.2		 1brpA-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 238
TRP A 236
TRP A 205
 OLA  A 501 ( 4.2A)
None
None
 1.07A 1c4dA-4k5yA:
undetectable
1c4dB-4k5yA:
undetectable		 1c4dA-4k5yA:
5.15
1c4dB-4k5yA:
5.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 1cbrA-1pmpA:
19.4		 1cbrA-1pmpA:
40.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 1cbrB-1pmpA:
19.4		 1cbrB-1pmpA:
40.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.76A 1cbsA-1pmpA:
19.2		 1cbsA-1pmpA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.13A 1dg5A-6ffhA:
undetectable		 1dg5A-6ffhA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FEM_A_REAA184_1
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 10 MET A  73
PHE A  45
LEU A  97
GLN A 117
TYR A 133
 OLA  A1179 ( 4.9A)
OLA  A1179 (-4.6A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
 1.36A 1femA-2wq9A:
22.4		 1femA-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FEM_A_REAA184_1
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 10 VAL A  61
MET A  73
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
GLN A 117
TYR A 133
 None
OLA  A1179 ( 4.9A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
 0.60A 1femA-2wq9A:
22.4		 1femA-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		6 / 11 LEU A  35
PHE A  45
ALA A  55
ALA A  57
MET A  88
TYR A  90
 OLA  A1179 (-4.8A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
 1.35A 1hbpA-2wq9A:
31.3		 1hbpA-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 11 PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
 0.59A 1hbpA-2wq9A:
31.3		 1hbpA-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 7 SER A  71
SER A 130
ARG A 133
LEU A 211
 OLA  A1207 (-3.2A)
None
PO4  A1205 (-2.5A)
None
 1.13A 1ibgL-5wivA:
undetectable		 1ibgL-5wivA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 11 LEU A  37
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
 0.52A 1iiuA-2wq9A:
30.5		 1iiuA-2wq9A:
86.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.06A 1j3jA-6ffhA:
undetectable		 1j3jA-6ffhA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 12 HIS A 278
ILE A  64
TYR A   9
ALA A  81
GLU A  13
 None
OLA  A1206 ( 4.0A)
None
None
None
 1.46A 1ki7A-6aqfA:
undetectable		 1ki7A-6aqfA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		6 / 7 LEU A  37
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
 0.64A 1kt3A-2wq9A:
25.6		 1kt3A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 1.14A 1kt4A-2wq9A:
31.7		 1kt4A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 12 LEU A  37
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
ARG A 121
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
OLA  A1179 ( 3.7A)
 0.46A 1kt4A-2wq9A:
31.7		 1kt4A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 12 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
ARG A 121
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
OLA  A1179 ( 3.7A)
 0.67A 1kt4A-2wq9A:
31.7		 1kt4A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 1.19A 1kt5A-2wq9A:
31.7		 1kt5A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		11 / 12 LEU A  37
PHE A  45
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
HIS A 104
ARG A 121
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
OLA  A1179 ( 3.7A)
 0.45A 1kt5A-2wq9A:
31.7		 1kt5A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 11 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
 0.73A 1kt6A-2wq9A:
30.5		 1kt6A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 11 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
 0.71A 1kt7A-2wq9A:
31.7		 1kt7A-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ILE A1791
PHE A1788
LEU A1786
ALA A1787
LEU A1808
 None
D7W  A4006 (-3.1A)
OLA  A4007 ( 4.3A)
OLA  A4007 ( 4.6A)
None
 1.22A 1og5B-6ffhA:
0.9		 1og5B-6ffhA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 12 PHE A  62
PHE A   2
SER A  91
PHE A  96
LEU A 111
 None
None
None
OLA  A 130 ( 4.2A)
None
 1.25A 1q23C-2ftbA:
undetectable		 1q23C-2ftbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 11 PHE A  62
PHE A   2
SER A  91
PHE A  96
LEU A 111
 None
None
None
OLA  A 130 ( 4.2A)
None
 1.29A 1q23L-2ftbA:
undetectable		 1q23L-2ftbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 9 LEU A  81
VAL A  74
ILE A  73
TYR A 448
ILE A 447
 None
OLA  A1207 ( 4.5A)
None
None
None
 1.28A 1q6iA-5wivA:
undetectable		 1q6iA-5wivA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 11 ALA A  43
VAL A  61
MET A  88
HIS A 104
TYR A 133
 OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 1.41A 1qabE-2wq9A:
26.1		 1qabE-2wq9A:
98.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		9 / 11 LEU A  37
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 0.85A 1qabE-2wq9A:
26.1		 1qabE-2wq9A:
98.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		9 / 11 LEU A  37
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
TYR A 133
 OLA  A1179 (-3.4A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 0.97A 1qabE-2wq9A:
26.1		 1qabE-2wq9A:
98.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		11 / 12 ALA A  55
ALA A  57
LEU A  63
MET A  73
GLY A  75
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 (-3.8A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
 0.67A 1qabF-2wq9A:
28.2		 1qabF-2wq9A:
98.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 6e12 -
(-) 		4 / 7 HIS A 120
TYR A 143
LEU A 147
GLN A 146
 OLA  A 301 (-3.8A)
None
OLA  A 301 ( 4.2A)
None
 0.87A 1qzrA-6e12A:
0.5		 1qzrA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 6e12 -
(-) 		4 / 7 HIS A 120
TYR A 143
LEU A 147
GLN A 146
 OLA  A 301 (-3.8A)
None
OLA  A 301 ( 4.2A)
None
 0.88A 1qzrB-6e12A:
undetectable		 1qzrB-6e12A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 12 LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
MET A  73
MET A  88
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
 0.57A 1rbpA-2wq9A:
31.6		 1rbpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 12 LEU A  37
ALA A  43
PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  88
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
 0.79A 1rbpA-2wq9A:
31.6		 1rbpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A  63
ALA A  43
ALA A  55
ALA A  57
MET A  73
 None
OLA  A1179 ( 4.0A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
 1.29A 1rbpA-2wq9A:
31.6		 1rbpA-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 10 LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  73
LEU A  97
GLN A  98
ASP A 102
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 4.9A)
None
None
None
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.79A 1rlbE-2wq9A:
31.1		 1rlbE-2wq9A:
92.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 11 LEU A  37
ALA A  55
ALA A  57
VAL A  61
LEU A  63
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
 0.82A 1rlbF-2wq9A:
30.5		 1rlbF-2wq9A:
92.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		4 / 6 ILE A  78
GLN A  95
VAL A  21
SER A  72
 None
None
OLA  A 130 ( 4.9A)
OLA  A 130 ( 3.8A)
 1.04A 1rs7B-2ftbA:
undetectable		 1rs7B-2ftbA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 12 LEU A  18
ALA A  31
ILE A  34
THR A  53
HIS A  98
LEU A 118
ARG A 120
 None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
None
 0.58A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		6 / 11 ASN A  60
ILE A  70
VAL A  82
PHE A  96
HIS A  98
GLN A 100
 None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.80A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 11 THR A  71
VAL A  82
PHE A  96
HIS A  98
GLN A 100
 None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 1.03A 1tw4A-2ftbA:
22.7		 1tw4A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 12 TYR A  14
LEU A  18
ILE A  34
THR A  53
HIS A  98
LEU A 118
ARG A 120
 None
None
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
None
 0.69A 1tw4B-2ftbA:
22.3		 1tw4B-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		6 / 10 ASN A  60
ILE A  70
VAL A  82
PHE A  96
HIS A  98
GLN A 100
 None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.84A 1tw4B-2ftbA:
22.3		 1tw4B-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 10 THR A  71
VAL A  82
PHE A  96
HIS A  98
GLN A 100
 None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.98A 1tw4B-2ftbA:
22.3		 1tw4B-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5lwe C-C CHEMOKINE
RECEPTOR TYPE 9
(Homo
sapiens) 		3 / 3 GLN A 150
ILE A 146
TYR A 145
 None
OLA  A 414 ( 4.9A)
OLA  A 405 (-3.9A)
 0.76A 1vifA-5lweA:
undetectable		 1vifA-5lweA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 285
VAL A 280
TRP A 282
 None
OLA  A1210 ( 4.5A)
None
 0.98A 1w5uC-5ee7A:
undetectable
1w5uD-5ee7A:
undetectable		 1w5uC-5ee7A:
4.11
1w5uD-5ee7A:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		4 / 6 MET A  73
VAL A  93
LEU A  97
PHE A  96
 OLA  A1179 ( 4.9A)
None
None
None
 1.20A 1x8vA-2wq9A:
undetectable		 1x8vA-2wq9A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 164
GLY A 165
LEU A 160
SER A 167
ASN A 174
 None
None
OLA  A1207 ( 4.0A)
None
None
 1.08A 1xdsA-5ee7A:
undetectable		 1xdsA-5ee7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 164
GLY A 165
LEU A 160
SER A 167
ASN A 174
 None
None
OLA  A1207 ( 4.0A)
None
None
 1.06A 1xdsB-5ee7A:
undetectable		 1xdsB-5ee7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 5 TRP A 407
PRO A 409
LEU A 405
GLY A 401
 None
PEG  A1215 ( 4.6A)
OLA  A1211 ( 4.6A)
OLA  A1211 (-3.6A)
 1.46A 1ya4C-5wivA:
0.9		 1ya4C-5wivA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A 120
CYH A 119
PRO A 204
VAL A 170
TYR A 192
 AQD  A1201 (-4.4A)
AQD  A1201 ( 3.9A)
OLA  A1209 ( 4.0A)
None
None
 1.31A 1z9hA-5wivA:
2.2		 1z9hA-5wivA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A 120
CYH A 119
PRO A 204
VAL A 170
TYR A 192
 AQD  A1201 (-4.4A)
AQD  A1201 ( 3.9A)
OLA  A1209 ( 4.0A)
None
None
 1.31A 1z9hB-5wivA:
undetectable		 1z9hB-5wivA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A 120
CYH A 119
PRO A 204
VAL A 170
TYR A 192
 AQD  A1201 (-4.4A)
AQD  A1201 ( 3.9A)
OLA  A1209 ( 4.0A)
None
None
 1.31A 1z9hC-5wivA:
2.2		 1z9hC-5wivA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.10A 2bl9A-6ffhA:
undetectable		 2bl9A-6ffhA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.16A 2blaA-6ffhA:
undetectable		 2blaA-6ffhA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 6e12 -
(-) 		4 / 8 ILE A  31
SER A  30
LEU A 156
GLU A 140
 OLA  A 301 (-4.6A)
None
None
OLA  A 301 (-3.4A)
 0.74A 2cdqA-6e12A:
undetectable		 2cdqA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 10 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.84A 2f16K-2wq9A:
undetectable
2f16L-2wq9A:
undetectable		 2f16K-2wq9A:
20.64
2f16L-2wq9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 10 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.85A 2f16Y-2wq9A:
undetectable
2f16Z-2wq9A:
undetectable		 2f16Y-2wq9A:
20.64
2f16Z-2wq9A:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 2fr3A-1pmpA:
19.3		 2fr3A-1pmpA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 12 ASN A  60
PHE A  62
ILE A  70
SER A  72
ILE A  78
CYH A  80
VAL A  82
 None
None
None
OLA  A 130 ( 3.8A)
None
None
None
 0.93A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		10 / 12 PHE A  17
VAL A  21
ASN A  60
PHE A  62
ILE A  70
CYH A  80
VAL A  82
PHE A  96
HIS A  98
LEU A 111
 None
OLA  A 130 ( 4.9A)
None
None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.61A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		10 / 12 PHE A  17
VAL A  21
ASN A  60
PHE A  62
ILE A  70
ILE A  78
CYH A  80
VAL A  82
PHE A  96
HIS A  98
 None
OLA  A 130 ( 4.9A)
None
None
None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
 0.59A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		6 / 12 VAL A 113
ASN A  60
PHE A  62
ILE A  70
SER A  72
ILE A  78
 None
None
None
None
OLA  A 130 ( 3.8A)
None
 1.17A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		6 / 11 ILE A  34
THR A  53
PRO A  54
ASN A  55
GLN A  56
MET A  73
 None
OLA  A 130 ( 4.7A)
None
None
OLA  A 130 ( 4.4A)
OLA  A 130 (-4.6A)
 1.26A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 11 ILE A  34
THR A  53
PRO A  54
ASN A  55
LEU A 111
 None
OLA  A 130 ( 4.7A)
None
None
None
 1.11A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 11 TYR A  14
LEU A  18
LEU A  23
ILE A  34
THR A  53
PRO A  54
GLN A  56
 None
None
None
None
OLA  A 130 ( 4.7A)
None
OLA  A 130 ( 4.4A)
 1.06A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		8 / 11 TYR A  14
LEU A  18
LEU A  23
ILE A  34
THR A  53
PRO A  54
LEU A 111
ARG A 120
 None
None
None
None
OLA  A 130 ( 4.7A)
None
None
None
 0.70A 2ft9A-2ftbA:
23.0		 2ft9A-2ftbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.22A 2j7xA-5ee7A:
undetectable		 2j7xA-5ee7A:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 12 TYR A  14
LEU A  18
ALA A  31
ILE A  34
THR A  53
GLN A  56
HIS A  98
 None
None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.4A)
OLA  A 130 ( 4.8A)
 1.12A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 12 TYR A  14
LEU A  18
ALA A  31
ILE A  34
THR A  53
HIS A  98
LEU A 118
 None
None
OLA  A 130 (-3.3A)
None
OLA  A 130 ( 4.7A)
OLA  A 130 ( 4.8A)
None
 0.82A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		8 / 12 VAL A  49
PHE A  62
ILE A  70
CYH A  80
VAL A  82
LEU A  89
PHE A  96
HIS A  98
 None
None
None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
 1.02A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		7 / 12 VAL A  49
PHE A  62
THR A  71
CYH A  80
VAL A  82
LEU A  89
HIS A  98
 None
None
None
None
None
None
OLA  A 130 ( 4.8A)
 1.40A 2jn3A-2ftbA:
21.2		 2jn3A-2ftbA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		4 / 6 VAL A 248
PHE A 211
PRO A 214
THR A 217
 OLA  A 417 ( 4.9A)
None
9P2  A 401 (-3.8A)
9P2  A 401 (-3.9A)
 1.46A 2q6oB-5o9hA:
undetectable		 2q6oB-5o9hA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		10 / 12 PHE A  16
VAL A  25
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.3A)
None
OLA  A 200 ( 4.0A)
OLA  A 200 ( 4.7A)
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.54A 2qm9A-1pmpA:
24.5		 2qm9A-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
OLA  A 200 (-4.6A)
None
None
 0.64A 2qm9A-1pmpA:
24.5		 2qm9A-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		11 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  55
THR A  60
ALA A  75
ARG A  78
ILE A 104
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
None
OLA  A 200 ( 4.3A)
None
OLA  A 200 ( 4.0A)
None
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.56A 2qm9B-1pmpA:
25.1		 2qm9B-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 OLA  A 200 (-4.6A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.2A)
 0.79A 2qm9B-1pmpA:
25.1		 2qm9B-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 12 TYR A  14
LEU A  18
ALA A  31
HIS A  98
ARG A 120
 None
None
OLA  A 130 (-3.3A)
OLA  A 130 ( 4.8A)
None
 0.88A 2qo4A-2ftbA:
21.5		 2qo4A-2ftbA:
69.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 9 TYR A  14
LEU A  18
ALA A  31
LEU A 111
ARG A 120
 None
None
OLA  A 130 (-3.3A)
None
None
 0.82A 2qo5A-2ftbA:
22.0		 2qo5A-2ftbA:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		6 / 12 ILE A  70
CYH A  80
VAL A  82
PHE A  96
HIS A  98
LEU A 111
 None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.64A 2qo5A-2ftbA:
22.0		 2qo5A-2ftbA:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		6 / 12 ILE A  70
THR A  71
CYH A  80
VAL A  82
PHE A  96
HIS A  98
 None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
 1.11A 2qo5A-2ftbA:
22.0		 2qo5A-2ftbA:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 12 TYR A  14
LEU A  18
ALA A  31
HIS A  98
ARG A 120
 None
None
OLA  A 130 (-3.3A)
OLA  A 130 ( 4.8A)
None
 0.86A 2qo6A-2ftbA:
19.2		 2qo6A-2ftbA:
69.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		5 / 12 TYR A  14
LEU A  18
LEU A  23
ALA A  31
ARG A 120
 None
None
None
OLA  A 130 (-3.3A)
None
 0.86A 2qo6A-2ftbA:
19.2		 2qo6A-2ftbA:
69.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		4 / 6 GLU A  13
MET A  19
PHE A 120
ILE A 118
 None
OLA  A 128 (-3.5A)
OLA  A 128 ( 4.3A)
None
 1.34A 2w98B-2lkkA:
undetectable		 2w98B-2lkkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 9 MET A  53
PHE A  77
SER A  46
ALA A  43
GLY A  75
 None
None
CL  A1177 (-4.3A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-3.8A)
 1.40A 2wscA-2wq9A:
undetectable		 2wscA-2wq9A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 9 MET A  53
PHE A  77
SER A  46
ALA A  43
GLY A  75
 None
None
CL  A1177 (-4.3A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-3.8A)
 1.40A 2wseA-2wq9A:
undetectable		 2wseA-2wq9A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 9 MET A  53
PHE A  77
SER A  46
ALA A  43
GLY A  75
 None
None
CL  A1177 (-4.3A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-3.8A)
 1.43A 2wsfA-2wq9A:
undetectable		 2wsfA-2wq9A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		3 / 3 SER A  33
THR A  37
PHE A  70
 None
None
OLA  A 304 ( 4.4A)
 0.76A 2x91A-4x6dA:
undetectable		 2x91A-4x6dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5lwe C-C CHEMOKINE
RECEPTOR TYPE 9
(Homo
sapiens) 		5 / 12 LEU A  87
GLY A  65
VAL A  58
LEU A 312
PHE A 308
 79K  A 401 (-4.3A)
OLA  A 412 ( 4.1A)
None
CLR  A 417 ( 4.7A)
OLA  A 402 (-4.1A)
 1.01A 2zzmA-5lweA:
undetectable		 2zzmA-5lweA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 8 GLU A  72
SER A  82
GLN A  93
CYH A 117
 None
None
None
OLA  A 200 ( 4.4A)
 1.17A 3b9lA-1pmpA:
undetectable		 3b9lA-1pmpA:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		6 / 11 ALA A  43
VAL A  61
MET A  88
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 1.28A 3bszE-2wq9A:
30.4		 3bszE-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		10 / 11 LEU A  37
ALA A  43
ALA A  57
MET A  73
MET A  88
LEU A  97
GLN A  98
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.55A 3bszE-2wq9A:
30.4		 3bszE-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		9 / 11 LEU A  37
ALA A  43
VAL A  61
MET A  88
LEU A  97
GLN A  98
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
None
OLA  A1179 ( 3.8A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.88A 3bszE-2wq9A:
30.4		 3bszE-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		6 / 11 ALA A  57
ALA A  55
MET A  88
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 ( 3.7A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 1.24A 3bszF-2wq9A:
30.4		 3bszF-2wq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		11 / 11 LEU A  37
ALA A  43
PHE A  45
ALA A  55
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
GLN A 117
PHE A 135
 OLA  A1179 (-3.4A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 (-4.3A)
 0.53A 3bszF-2wq9A:
30.4		 3bszF-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 PHE A 377
CYH A 415
PHE A 353
 OLA  A 610 ( 4.2A)
OLA  A 609 ( 4.4A)
None
 0.96A 3cr5X-4ikvA:
undetectable		 3cr5X-4ikvA:
9.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 12 PHE A  63
THR A  73
VAL A  83
LEU A  91
THR A 102
 OLA  A 129 ( 3.9A)
None
None
None
OLA  A 129 (-2.7A)
 0.78A 3elzA-2lkkA:
16.2		 3elzA-2lkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 12 ILE A  22
THR A  73
VAL A  83
LEU A  91
THR A 102
 None
None
None
None
OLA  A 129 (-2.7A)
 0.87A 3em0B-2lkkA:
16.9		 3em0B-2lkkA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 12 PHE A  18
ILE A  22
VAL A  83
LEU A  91
THR A 102
 OLA  A 129 ( 4.8A)
None
None
None
OLA  A 129 (-2.7A)
 0.56A 3em0B-2lkkA:
16.9		 3em0B-2lkkA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A  90
TYR A 375
PHE A 379
TYR A 382
 OLA  A1210 (-3.9A)
None
None
None
 1.24A 3ku9B-6bqhA:
undetectable		 3ku9B-6bqhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 285
VAL A 280
TRP A 282
 None
OLA  A1210 ( 4.5A)
None
 0.90A 3l8lC-5ee7A:
undetectable
3l8lD-5ee7A:
undetectable		 3l8lC-5ee7A:
4.11
3l8lD-5ee7A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 9 MET A  53
PHE A  77
SER A  46
ALA A  43
GLY A  75
 None
None
CL  A1177 (-4.3A)
OLA  A1179 ( 4.0A)
OLA  A1179 (-3.8A)
 1.42A 3lw5A-2wq9A:
undetectable		 3lw5A-2wq9A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.85A 3mg0Y-2wq9A:
undetectable
3mg0Z-2wq9A:
undetectable		 3mg0Y-2wq9A:
20.64
3mg0Z-2wq9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 10 ILE A  52
PHE A  50
ILE A  59
SER A 100
LEU A  71
 OLA  A 128 (-3.7A)
OLA  A 129 ( 3.9A)
OLA  A 129 ( 3.8A)
OLA  A 129 ( 3.6A)
OLA  A 129 (-3.8A)
 1.25A 3o1xA-2lkkA:
undetectable		 3o1xA-2lkkA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		12 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
None
None
OLA  A 200 ( 4.7A)
None
None
OLA  A 200 (-3.2A)
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.70A 3p6gA-1pmpA:
24.3		 3p6gA-1pmpA:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		8 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
None
None
OLA  A 200 ( 4.7A)
None
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 1.23A 3p6gA-1pmpA:
24.3		 3p6gA-1pmpA:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		7 / 7 PHE A  16
MET A  20
ASP A  76
ILE A 104
VAL A 115
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
OLA  A 200 ( 4.7A)
None
None
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.59A 3p6hA-1pmpA:
24.3		 3p6hA-1pmpA:
65.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.09A 3qgtA-6ffhA:
undetectable		 3qgtA-6ffhA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.08A 3qgtB-6ffhA:
undetectable		 3qgtB-6ffhA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 10 ILE A  52
PHE A  50
ILE A  59
SER A 100
LEU A  71
 OLA  A 128 (-3.7A)
OLA  A 129 ( 3.9A)
OLA  A 129 ( 3.8A)
OLA  A 129 ( 3.6A)
OLA  A 129 (-3.8A)
 1.25A 3qgzA-2lkkA:
undetectable		 3qgzA-2lkkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.07A 3sudA-4yziA:
undetectable		 3sudA-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.02A 3sudD-4yziA:
undetectable		 3sudD-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.11A 3sueB-4yziA:
undetectable		 3sueB-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ILE A 636
ALA A 579
ASP A 577
SER A1795
ILE A1799
 OLA  A4004 (-4.6A)
None
None
None
MES  A4005 (-4.1A)
 1.16A 3tq8A-6ffhA:
undetectable		 3tq8A-6ffhA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.72A 4ac9C-4yziA:
undetectable		 4ac9C-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.77A 4acaC-4yziA:
undetectable		 4acaC-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		4 / 6 THR A 285
GLY A 287
ILE A 291
LEU A  94
 None
OLA  A 406 (-3.5A)
None
None
 0.83A 4acbC-4yziA:
undetectable		 4acbC-4yziA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		4 / 6 ILE A  78
GLN A  95
VAL A  21
SER A  72
 None
None
OLA  A 130 ( 4.9A)
OLA  A 130 ( 3.8A)
 1.10A 4d39B-2ftbA:
undetectable		 4d39B-2ftbA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5lwe C-C CHEMOKINE
RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 5 ASP A  94
ASN A 313
ILE A 137
VAL A 262
 None
None
None
OLA  A 402 ( 4.0A)
 1.26A 4hytA-5lweA:
2.2		 4hytA-5lweA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 6 ILE A 263
THR A 260
VAL A 158
SER A 119
 OLA  A 301 ( 3.7A)
None
None
OLA  A 301 ( 3.3A)
 1.12A 4iaqA-4x9xA:
undetectable		 4iaqA-4x9xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 GLY A 139
GLY A 142
ILE A 137
ILE A 136
SER A 160
 RET  A1273 ( 3.7A)
None
OLA  A1276 ( 4.4A)
None
RET  A1273 (-3.3A)
 1.07A 4iv0B-5g2cA:
undetectable		 4iv0B-5g2cA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.26A 4j26A-5ee7A:
undetectable		 4j26A-5ee7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		5 / 10 TRP A  14
VAL A  28
ILE A  13
LEU A 162
LEU A 114
 OLA  A 304 ( 4.3A)
None
None
None
None
 1.29A 4jtqA-4x6dA:
undetectable		 4jtqA-4x6dA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3lsp DEST
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  96
GLU A  66
SER A 105
LEU A 108
ILE A 173
 OLA  A 221 ( 4.6A)
None
SO4  A 222 ( 4.4A)
None
None
 1.41A 4k39A-3lspA:
undetectable		 4k39A-3lspA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER
(Ambystoma
mexicanum) 		4 / 6 ILE A  78
GLN A  95
VAL A  21
SER A  72
 None
None
OLA  A 130 ( 4.9A)
OLA  A 130 ( 3.8A)
 0.96A 4kcnA-2ftbA:
undetectable		 4kcnA-2ftbA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		5 / 12 ALA A  66
LEU A 127
LEU A 126
ALA A  72
TYR A 300
 OLA  A 407 ( 4.3A)
None
None
None
None
 1.06A 4lg1A-5o9hA:
undetectable		 4lg1A-5o9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 GLY A 139
GLY A 142
ILE A 137
ILE A 136
SER A 160
 RET  A1273 ( 3.7A)
None
OLA  A1276 ( 4.4A)
None
RET  A1273 (-3.3A)
 1.07A 4mwzA-5g2cA:
undetectable		 4mwzA-5g2cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 8 GLN A  95
PHE A  70
THR A  53
THR A  60
 None
None
OLA  A 200 ( 4.7A)
None
 0.86A 4n16A-1pmpA:
undetectable		 4n16A-1pmpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		3 / 3 ILE A 118
ASP A   9
ARG A 170
 OLA  A 301 (-3.7A)
None
OLA  A 301 (-3.3A)
 0.79A 4pstA-4x9xA:
undetectable		 4pstA-4x9xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		6 / 12 ILE A 130
LEU A 323
ALA A  72
TRP A  74
ILE A 299
TYR A 222
 None
None
None
None
OLA  A 414 ( 4.2A)
None
 1.46A 4psyA-5o9hA:
undetectable		 4psyA-5o9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.22A 4pxmB-5ee7A:
undetectable		 4pxmB-5ee7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 12 GLY A 121
GLY A 123
ILE A 118
LEU A 277
VAL A 275
 None
None
OLA  A 301 (-3.7A)
None
None
 1.05A 4qdjA-4x9xA:
undetectable		 4qdjA-4x9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 12 SER A 264
ASP A  40
PHE A  49
ALA A 232
ASP A  13
 EDO  A 302 (-2.7A)
None
EDO  A 302 ( 4.8A)
EDO  A 302 (-2.7A)
OLA  A 301 ( 4.7A)
 1.20A 4ubeA-4x9xA:
undetectable		 4ubeA-4x9xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 GLY A 628
LEU A 630
LEU A1814
ALA A 593
PHE A 633
 D7W  A4006 (-3.4A)
YCM  A 634 ( 4.2A)
None
None
OLA  A4004 (-4.8A)
 1.17A 4wnuA-6ffhA:
undetectable		 4wnuA-6ffhA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ASN A  52
SER A 122
ALA A  77
VAL A  74
 None
NA  A1224 (-2.3A)
None
OLA  A1207 ( 4.5A)
 1.20A 4x1kC-5wivA:
undetectable		 4x1kC-5wivA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		5 / 12 LEU A 323
GLY A 304
ALA A 303
ILE A 299
VAL A 247
 None
None
OLA  A 414 ( 4.3A)
OLA  A 414 ( 4.2A)
None
 0.91A 4xdrA-5o9hA:
undetectable		 4xdrA-5o9hA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 11 TYR A  73
GLY A 190
VAL A 176
SER A  38
GLY A  41
 None
OLA  A 607 ( 4.1A)
None
None
None
 1.14A 4xnxA-4ikvA:
2.3		 4xnxA-4ikvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		5 / 11 GLY A 268
ILE A 171
LEU A 195
LEU A  92
ILE A 263
 None
None
OLA  A 301 ( 3.9A)
OLA  A 301 (-3.6A)
OLA  A 301 ( 3.7A)
 1.17A 4xumB-4x9xA:
undetectable		 4xumB-4x9xA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		3 / 3 THR A 267
HIS A  87
LEU A  29
 OLA  A 301 ( 3.4A)
None
OLA  A 301 (-4.4A)
 0.67A 5axdA-4x9xA:
2.5		 5axdA-4x9xA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
TYR A  19
VAL A  25
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.71A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
VAL A  25
PRO A  38
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.77A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 VAL A 104
TRP A  98
ILE A 187
ILE A  80
ILE A  81
 OLA  A1209 (-4.8A)
None
P6G  A1205 (-4.2A)
None
None
 1.05A 5hw8A-5dsgA:
undetectable
5hw8D-5dsgA:
undetectable		 5hw8A-5dsgA:
15.13
5hw8D-5dsgA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 5 HIS A 266
VAL A 157
GLY A 160
ALA A 271
 OLA  A 301 (-2.7A)
OLA  A 301 ( 3.6A)
None
OLA  A 301 (-3.0A)
 0.90A 5hwaA-4x9xA:
undetectable		 5hwaA-4x9xA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.32A 5j7wC-5ee7A:
undetectable		 5j7wC-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ASN A 125
VAL A 166
SER A 163
THR A 159
PRO A 169
 None
OLA  A1209 ( 4.9A)
None
None
None
 1.22A 5jh7B-5wivA:
undetectable		 5jh7B-5wivA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 9 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.83A 5l5zK-2wq9A:
undetectable
5l5zL-2wq9A:
undetectable		 5l5zK-2wq9A:
18.87
5l5zL-2wq9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 9 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.83A 5l5zY-2wq9A:
undetectable
5l5zZ-2wq9A:
undetectable		 5l5zY-2wq9A:
18.87
5l5zZ-2wq9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 7 GLN A  95
PHE A  70
THR A  53
THR A  60
 None
None
OLA  A 200 ( 4.7A)
None
 0.90A 5m78A-1pmpA:
undetectable		 5m78A-1pmpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ASN A  27
SER A  94
ALA A  52
VAL A  49
 None
None
None
OLA  A1203 (-4.0A)
 1.07A 5nm5A-5uenA:
undetectable		 5nm5A-5uenA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 6e12 -
(-) 		5 / 12 ILE A  31
LEU A 156
HIS A 120
SER A  23
GLY A  26
 OLA  A 301 (-4.6A)
None
OLA  A 301 (-3.8A)
None
OLA  A 301 (-3.9A)
 1.18A 5nnaA-6e12A:
undetectable		 5nnaA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 6e12 -
(-) 		5 / 12 ILE A  31
LEU A 156
HIS A 120
SER A  23
GLY A  26
 OLA  A 301 (-4.6A)
None
OLA  A 301 (-3.8A)
None
OLA  A 301 (-3.9A)
 1.19A 5nnaB-6e12A:
undetectable		 5nnaB-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 6e12 -
(-) 		5 / 12 ILE A  31
LEU A 156
HIS A 120
SER A  23
GLY A  26
 OLA  A 301 (-4.6A)
None
OLA  A 301 (-3.8A)
None
OLA  A 301 (-3.9A)
 1.20A 5nnaC-6e12A:
undetectable		 5nnaC-6e12A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		8 / 8 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
 0.68A 5nu7A-2wq9A:
33.1		 5nu7A-2wq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 6e12 -
(-) 		3 / 3 HIS A  90
HIS A 124
HIS A 120
 None
None
OLA  A 301 (-3.8A)
 0.99A 5oexA-6e12A:
undetectable		 5oexA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 5 ALA A 587
VAL A 585
PHE A 633
ILE A 581
 None
OLA  A4002 ( 4.3A)
OLA  A4004 (-4.8A)
None
 1.03A 5of1B-6ffhA:
undetectable		 5of1B-6ffhA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 8 SER A 186
ILE A  97
ALA A  98
LEU A 101
 None
OLA  A1210 (-4.2A)
None
OLA  A1209 ( 4.8A)
 0.83A 5te8B-6bqhA:
1.5		 5te8B-6bqhA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lwe C-C CHEMOKINE
RECEPTOR TYPE 9
(Homo
sapiens) 		4 / 9 ILE A 257
TYR A 234
ILE A 238
ILE A 242
 OLA  A 402 ( 4.5A)
OLA  A 404 (-3.8A)
None
None
 0.74A 5vkqB-5lweA:
2.2
5vkqC-5lweA:
2.1		 5vkqB-5lweA:
11.35
5vkqC-5lweA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		5 / 10 ILE A 124
TRP A 154
ILE A  70
ALA A 153
ALA A 158
 9P2  A 401 (-4.4A)
None
TLA  A 402 (-3.3A)
OLA  A 404 ( 4.0A)
OLA  A 416 (-3.5A)
 1.43A 5zjiB-5o9hA:
2.1		 5zjiB-5o9hA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nyq MILK PROTEIN
(Diploptera
punctata) 		4 / 7 ILE A  29
GLN A  32
ILE A  36
THR A  52
 None
EIC  A 208 (-3.8A)
OLA  A 207 ( 4.6A)
NAG  A 201 (-3.7A)
 0.98A 6cduF-4nyqA:
undetectable
6cduG-4nyqA:
undetectable		 6cduF-4nyqA:
16.72
6cduG-4nyqA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		5 / 12 VAL A  59
VAL A 248
ASN A 292
ASN A 296
TYR A 300
 None
OLA  A 417 ( 4.9A)
None
None
None
 1.49A 6h7lA-5o9hA:
20.7		 6h7lA-5o9hA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens) 		5 / 9 TRP A 161
ILE A  70
ALA A 153
LEU A 156
ALA A 160
 None
TLA  A 402 (-3.3A)
OLA  A 404 ( 4.0A)
9P2  A 401 (-3.9A)
9P2  A 401 ( 3.9A)
 1.46A 6hqbB-5o9hA:
1.2		 6hqbB-5o9hA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4x9x DEGV
DOMAIN-CONTAINING
PROTEIN MW1315
(Staphylococcus
aureus) 		4 / 8 GLN A 127
ILE A 118
ALA A 230
VAL A 229
 None
OLA  A 301 (-3.7A)
OLA  A 301 ( 3.1A)
None
 0.98A 6hu9a-4x9xA:
undetectable
6hu9e-4x9xA:
undetectable		 6hu9a-4x9xA:
18.61
6hu9e-4x9xA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 11 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.86A 6hwdK-2wq9A:
undetectable
6hwdL-2wq9A:
undetectable		 6hwdK-2wq9A:
19.54
6hwdL-2wq9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens) 		5 / 11 ALA A  57
THR A  56
ALA A  55
ALA A  43
GLY A  92
 OLA  A1179 ( 3.7A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
None
 0.86A 6hwdY-2wq9A:
undetectable
6hwdZ-2wq9A:
undetectable		 6hwdY-2wq9A:
19.54
6hwdZ-2wq9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.25A 6qxsD-5ee7A:
undetectable		 6qxsD-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.30A 6qyaB-5ee7A:
undetectable		 6qyaB-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.30A 6qyaD-5ee7A:
undetectable		 6qyaD-5ee7A:
21.15