SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OHS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		5 / 12 GLY A 244
GLY A 243
VAL A 178
LEU A 268
HIS A  42
 OHS  A 245 ( 2.4A)
None
None
None
None
 1.05A 1mx1F-1y9aA:
undetectable		 1mx1F-1y9aA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.74A 1q23C-1y9aA:
undetectable		 1q23C-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.74A 1q23H-1y9aA:
undetectable		 1q23H-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.77A 1q23L-1y9aA:
undetectable		 1q23L-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Entamoeba
histolytica) 		3 / 3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.75A 1q23J-1y9aA:
undetectable		 1q23J-1y9aA:
17.40