SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OHI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 6g1i -
(-) 		3 / 3 ASP A 141
ASP A 258
LYS A 265
 MN  A 409 (-2.6A)
None
OHI  A 264 ( 3.0A)
 0.94A 1lqtB-6g1iA:
undetectable		 1lqtB-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 6g1i -
(-) 		3 / 3 ASP A 141
ASP A 258
LYS A 265
 MN  A 409 (-2.6A)
None
OHI  A 264 ( 3.0A)
 0.93A 1lquB-6g1iA:
undetectable		 1lquB-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN
(Hahella
chejuensis) 		4 / 5 TYR A 416
TYR A 304
ILE A 348
GLY A 414
 None
GOL  A 806 (-4.8A)
None
OHI  A 352 ( 3.5A)
 1.36A 2du8J-4fusA:
undetectable		 2du8J-4fusA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 6g1i -
(-) 		4 / 5 ILE A 261
TYR A 230
ARG A 268
GLY A 266
 None
None
None
OHI  A 264 ( 4.4A)
 1.24A 3b9mA-6g1iA:
undetectable		 3b9mA-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN
(Hahella
chejuensis) 		5 / 12 PHE A 428
GLY A 430
ASP A 302
ALA A 408
VAL A 353
 None
None
None
None
OHI  A 352 ( 3.1A)
 1.06A 4dx5B-4fusA:
2.1		 4dx5B-4fusA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN
(Hahella
chejuensis) 		5 / 12 PHE A 428
GLY A 430
ASP A 302
ALA A 408
VAL A 353
 None
None
None
None
OHI  A 352 ( 3.1A)
 1.06A 4u8vB-4fusA:
undetectable		 4u8vB-4fusA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN
(Hahella
chejuensis) 		5 / 12 PHE A 428
GLY A 430
ASP A 302
ALA A 408
VAL A 353
 None
None
None
None
OHI  A 352 ( 3.1A)
 1.10A 4u8yB-4fusA:
undetectable		 4u8yB-4fusA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN
(Hahella
chejuensis) 		5 / 12 PHE A 428
GLY A 430
ASP A 302
ALA A 408
VAL A 353
 None
None
None
None
OHI  A 352 ( 3.1A)
 1.13A 4u95B-4fusA:
undetectable		 4u95B-4fusA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN
(Hahella
chejuensis) 		4 / 7 ASP A 160
PRO A 161
TYR A 321
SER A 329
 None
EDO  A 819 ( 4.7A)
None
OHI  A 352 ( 4.4A)
 1.22A 5l1fC-4fusA:
undetectable		 5l1fC-4fusA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 6g1i -
(-) 		4 / 7 PRO A 222
ILE A 168
ILE A 169
ILE A 267
 None
None
None
OHI  A 264 ( 4.0A)
 0.84A 5murB-6g1iA:
undetectable		 5murB-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 6g1i -
(-) 		5 / 11 ILE A 267
ALA A 274
LEU A 291
GLY A 293
ALA A 229
 OHI  A 264 ( 4.0A)
None
None
None
None
 1.25A 6ieyA-6g1iA:
undetectable
6ieyB-6g1iA:
undetectable		 6ieyA-6g1iA:
undetectable
6ieyB-6g1iA:
undetectable