SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OGA'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4L_A_DCFA353_1 (ADENOSINE DEAMINASE) |
4bhi | GAMMA-BUTYROBETAINEDIOXYGENASE (Homosapiens) | 5 / 12 | HIS A 202ASP A 261ALA A 193HIS A 347ASP A 204 | ZN A 402 ( 3.3A)RUJ A 401 ( 4.7A)OGA A 400 (-3.1A) ZN A 402 ( 3.3A) ZN A 402 (-2.6A) | 1.26A | 1a4lA-4bhiA:undetectable | 1a4lA-4bhiA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4L_C_DCFC1353_1 (ADENOSINE DEAMINASE) |
4bhi | GAMMA-BUTYROBETAINEDIOXYGENASE (Homosapiens) | 5 / 12 | HIS A 202ASP A 261ALA A 193HIS A 347ASP A 204 | ZN A 402 ( 3.3A)RUJ A 401 ( 4.7A)OGA A 400 (-3.1A) ZN A 402 ( 3.3A) ZN A 402 (-2.6A) | 1.25A | 1a4lC-4bhiA:undetectable | 1a4lC-4bhiA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1EI6_A_PPFA410_1 (PHOSPHONOACETATEHYDROLASE) |
2rds | FE(II)/ALPHA-KETOGLUTARATE DEPENDENTHYDROXYLASE1-DEOXYPENTALENICACID 11-BETAHYDROXYLASE (Streptomycesavermitilis) | 4 / 5 | THR A 151ASP A 139HIS A 137HIS A 226 | OGA A 268 (-3.8A) FE A 1 ( 2.6A) FE A 1 (-3.4A) FE A 1 ( 3.4A) | 1.16A | 1ei6A-2rdsA:undetectable | 1ei6A-2rdsA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MEI_A_MOAA600_1 (INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE) |
5jz8 | ASPARTYL/ASPARAGINYLBETA-HYDROXYLASE (Homosapiens) | 4 / 8 | ASP A 721SER A 722SER A 563ARG A 662 | OGA A 802 ( 4.8A)NoneNoneNone | 0.95A | 1meiA-5jz8A:undetectable | 1meiA-5jz8A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ONI_D_BEZD507_0 (14.5 KDATRANSLATIONALINHIBITOR PROTEIN) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 4 / 7 | ARG A 277ALA A 279ILE A 186ILE A 95 | OGA A 402 (-2.7A)OGA A 402 (-3.6A)ARG A 403 (-4.7A)None | 0.79A | 1oniD-5lunA:undetectable1oniF-5lunA:undetectable | 1oniD-5lunA:17.011oniF-5lunA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1Q23_A_FUAA702_1 (CHLORAMPHENICOLACETYLTRANSFERASE) |
3pua | PHD FINGER PROTEIN 2 (Homosapiens) | 5 / 12 | THR A 325TYR A 259PHE A 268SER A 244ALA A 333 | NoneOGA A 454 (-4.6A)NoneNoneEDO A 9 ( 3.9A) | 1.29A | 1q23A-3puaA:undetectable1q23B-3puaA:undetectable | 1q23A-3puaA:18.251q23B-3puaA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
2rds | 1-DEOXYPENTALENICACID 11-BETAHYDROXYLASE FE(II)/ALPHA-KETOGLUTARATE DEPENDENTHYDROXYLASE (Streptomycesavermitilis) | 5 / 12 | LEU A 218HIS A 137ASP A 139SER A 172PHE A 220 | None FE A 1 (-3.4A) FE A 1 ( 2.6A)NoneOGA A 268 (-4.9A) | 1.46A | 1uobA-2rdsA:9.9 | 1uobA-2rdsA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
4j25 | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasputida) | 5 / 12 | HIS A 124ASP A 126HIS A 183SER A 194VAL A 139 | MN A 401 ( 3.3A) MN A 401 ( 2.6A) MN A 401 ( 3.3A)OGA A 402 ( 3.7A)OGA A 402 ( 4.9A) | 1.44A | 1uobA-4j25A:10.3 | 1uobA-4j25A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
4j25 | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasputida) | 5 / 12 | HIS A 124ASP A 126LEU A 154HIS A 183SER A 194 | MN A 401 ( 3.3A) MN A 401 ( 2.6A)OGA A 402 (-3.7A) MN A 401 ( 3.3A)OGA A 402 ( 3.7A) | 0.61A | 1uobA-4j25A:10.3 | 1uobA-4j25A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
4lt5 | NAEGLERIA TET-LIKEDIOXYGENASE (Naegleriagruberi) | 5 / 12 | HIS A 229ASP A 231LEU A 253HIS A 279VAL A 293 | MN A 401 ( 3.4A) MN A 401 ( 2.7A)OGA A 413 (-3.8A) MN A 401 ( 3.4A)OGA A 413 (-4.9A) | 0.68A | 1uobA-4lt5A:8.2 | 1uobA-4lt5A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 12 | HIS A1382ASP A1384HIS A1881SER A1898VAL A1900 | FE A2003 (-3.3A) FE A2003 ( 2.4A) FE A2003 ( 3.2A)OGA A2001 (-2.7A)OGA A2001 ( 4.9A) | 0.61A | 1uobA-5deuA:7.6 | 1uobA-5deuA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 12 | SER A1286HIS A1881LEU A1872SER A1898VAL A1900 | None FE A2003 ( 3.2A)NoneOGA A2001 (-2.7A)OGA A2001 ( 4.9A) | 1.50A | 1uobA-5deuA:7.6 | 1uobA-5deuA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOB_A_PNNA1311_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 12 | HIS A 189ASP A 191LEU A 206HIS A 268PHE A 283 | FE A 401 (-3.3A) FE A 401 (-2.4A)OGA A 402 (-3.5A) FE A 401 ( 3.2A)ARG A 403 ( 4.2A) | 0.50A | 1uobA-5lunA:21.1 | 1uobA-5lunA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
2rds | 1-DEOXYPENTALENICACID 11-BETAHYDROXYLASE FE(II)/ALPHA-KETOGLUTARATE DEPENDENTHYDROXYLASE (Streptomycesavermitilis) | 5 / 11 | HIS A 137ASP A 139HIS A 226ARG A 240SER A 242 | FE A 1 (-3.4A) FE A 1 ( 2.6A) FE A 1 ( 3.4A)OGA A 268 (-2.9A)OGA A 268 ( 4.5A) | 1.03A | 1uofA-2rdsA:5.7 | 1uofA-2rdsA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
2rds | 1-DEOXYPENTALENICACID 11-BETAHYDROXYLASE FE(II)/ALPHA-KETOGLUTARATE DEPENDENTHYDROXYLASE (Streptomycesavermitilis) | 5 / 11 | HIS A 137ASP A 139THR A 151HIS A 226SER A 242 | FE A 1 (-3.4A) FE A 1 ( 2.6A)OGA A 268 (-3.8A) FE A 1 ( 3.4A)OGA A 268 ( 4.5A) | 0.64A | 1uofA-2rdsA:5.7 | 1uofA-2rdsA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
2rds | 1-DEOXYPENTALENICACID 11-BETAHYDROXYLASE FE(II)/ALPHA-KETOGLUTARATE DEPENDENTHYDROXYLASE (Streptomycesavermitilis) | 5 / 11 | PHE A 73HIS A 137ASP A 139THR A 151HIS A 226 | None FE A 1 (-3.4A) FE A 1 ( 2.6A)OGA A 268 (-3.8A) FE A 1 ( 3.4A) | 0.88A | 1uofA-2rdsA:5.7 | 1uofA-2rdsA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
4j25 | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasputida) | 6 / 11 | HIS A 124ASP A 126HIS A 183VAL A 185SER A 194VAL A 139 | MN A 401 ( 3.3A) MN A 401 ( 2.6A) MN A 401 ( 3.3A)NoneOGA A 402 ( 3.7A)OGA A 402 ( 4.9A) | 1.36A | 1uofA-4j25A:9.4 | 1uofA-4j25A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
4lt5 | NAEGLERIA TET-LIKEDIOXYGENASE (Naegleriagruberi) | 5 / 11 | HIS A 229ASP A 231HIS A 279VAL A 281VAL A 293 | MN A 401 ( 3.4A) MN A 401 ( 2.7A) MN A 401 ( 3.4A)OGA A 413 (-4.8A)OGA A 413 (-4.9A) | 0.60A | 1uofA-4lt5A:2.7 | 1uofA-4lt5A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 11 | HIS A1382ASP A1384ARG A1896SER A1898VAL A1900 | FE A2003 (-3.3A) FE A2003 ( 2.4A)OGA A2001 (-2.9A)OGA A2001 (-2.7A)OGA A2001 ( 4.9A) | 1.00A | 1uofA-5deuA:7.1 | 1uofA-5deuA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 11 | HIS A1382ASP A1384HIS A1881SER A1898VAL A1900 | FE A2003 (-3.3A) FE A2003 ( 2.4A) FE A2003 ( 3.2A)OGA A2001 (-2.7A)OGA A2001 ( 4.9A) | 0.79A | 1uofA-5deuA:7.1 | 1uofA-5deuA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 11 | HIS A1382THR A1393HIS A1881SER A1898VAL A1900 | FE A2003 (-3.3A) CL A2007 (-4.5A) FE A2003 ( 3.2A)OGA A2001 (-2.7A)OGA A2001 ( 4.9A) | 0.74A | 1uofA-5deuA:7.1 | 1uofA-5deuA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UOF_A_PNNA1312_0 (DEACETOXYCEPHALOSPORIN C SYNTHETASE) |
5jz8 | ASPARTYL/ASPARAGINYLBETA-HYDROXYLASE (Homosapiens) | 5 / 11 | HIS A 679HIS A 725VAL A 727ARG A 735SER A 668 | MN A 801 ( 3.4A) MN A 801 ( 3.4A)OGA A 802 ( 4.9A)OGA A 802 (-2.2A)OGA A 802 (-2.5A) | 1.18A | 1uofA-5jz8A:6.9 | 1uofA-5jz8A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BM9_A_SAMA301_1 (CEPHALOSPORINHYDROXYLASE CMCI) |
6fqc | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homosapiens) | 3 / 3 | LYS A 204ASP A 189ASN A 197 | OGA A 506 (-2.9A) MN A 501 ( 2.6A)OGA A 506 (-3.6A) | 1.13A | 2bm9A-6fqcA:undetectable | 2bm9A-6fqcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXP_A_P1ZA3001_1 (SERUM ALBUMIN) |
2xdv | MYC-INDUCED NUCLEARANTIGEN (Homosapiens) | 5 / 12 | LEU A 198PHE A 234LEU A 226ILE A 187ALA A 242 | NoneNoneNoneNoneOGA A 601 ( 4.2A) | 1.18A | 2bxpA-2xdvA:undetectable | 2bxpA-2xdvA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FJ1_A_CTCA222_0 (TETRACYCLINEREPRESSOR PROTEINCLASS D) |
2xdv | MYC-INDUCED NUCLEARANTIGEN (Homosapiens) | 5 / 12 | SER A 257PRO A 140THR A 255VAL A 254ILE A 150 | NoneNoneOGA A 601 (-3.0A)NoneNone | 1.42A | 2fj1A-2xdvA:undetectable | 2fj1A-2xdvA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FQY_A_ADNA400_1 (MEMBRANE LIPOPROTEINTMPC) |
5jz8 | ASPARTYL/ASPARAGINYLBETA-HYDROXYLASECOAGULATION FACTOR X (Homosapiens) | 5 / 12 | GLY A 663ASP A 741PHE A 719GLY A 681ASP B 103 | NoneNoneOGA A 802 (-4.9A)NoneOGA A 802 ( 3.2A) | 1.25A | 2fqyA-5jz8A:undetectable | 2fqyA-5jz8A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VCT_A_ASDA1223_1 (GLUTATHIONES-TRANSFERASE A2) |
3n9o | PUTATIVEUNCHARACTERIZEDPROTEIN (Caenorhabditiselegans) | 4 / 8 | GLY A 579LEU A 484LEU A 423PHE A 498 | NoneNoneOGA A 4 (-4.4A)None | 0.73A | 2vctA-3n9oA:3.5 | 2vctA-3n9oA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VCT_B_ASDB1223_1 (GLUTATHIONES-TRANSFERASE A2) |
3n9o | PUTATIVEUNCHARACTERIZEDPROTEIN (Caenorhabditiselegans) | 4 / 8 | GLY A 579LEU A 484LEU A 423PHE A 498 | NoneNoneOGA A 4 (-4.4A)None | 0.75A | 2vctB-3n9oA:5.0 | 2vctB-3n9oA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZS9_A_PAUA603_0 (PANTOTHENATE KINASE) |
3kv4 | PHD FINGER PROTEIN 8 (Homosapiens) | 4 / 6 | ASP A 249HIS A 319TYR A 257ASN A 189 | FE2 A 450 ( 2.5A)FE2 A 450 ( 3.4A)OGA A5798 (-4.2A)OGA A5798 (-3.7A) | 1.14A | 2zs9A-3kv4A:undetectable | 2zs9A-3kv4A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZS9_A_PAUA603_0 (PANTOTHENATE KINASE) |
3n9o | PUTATIVEUNCHARACTERIZEDPROTEIN (Caenorhabditiselegans) | 4 / 6 | ASP A 497HIS A 567TYR A 505ASN A 421 | FE2 A 1 ( 2.6A)FE2 A 1 ( 3.3A)OGA A 4 (-4.1A)OGA A 4 (-4.0A) | 1.16A | 2zs9A-3n9oA:undetectable | 2zs9A-3n9oA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZS9_A_PAUA603_0 (PANTOTHENATE KINASE) |
4lt5 | NAEGLERIA TET-LIKEDIOXYGENASE (Naegleriagruberi) | 4 / 6 | VAL A 293ASP A 234HIS A 297ASN A 214 | OGA A 413 (-4.9A)NoneNoneOGA A 413 (-3.3A) | 1.36A | 2zs9A-4lt5A:undetectable | 2zs9A-4lt5A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AVO_A_PAUA314_0 (PANTOTHENATE KINASE) |
4lt5 | NAEGLERIA TET-LIKEDIOXYGENASE (Naegleriagruberi) | 5 / 11 | VAL A 293ASP A 234HIS A 297ILE A 225ASN A 214 | OGA A 413 (-4.9A)NoneNoneOGA A 413 (-4.1A)OGA A 413 (-3.3A) | 1.49A | 3avoA-4lt5A:undetectable | 3avoA-4lt5A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IHZ_A_FK5A501_2 (70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 4 / 8 | ASP A1376TYR A1245SER A1898ILE A1897 | NoneNoneOGA A2001 (-2.7A)None | 0.89A | 3ihzB-5deuA:undetectable | 3ihzB-5deuA:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLEFACTOR 1-ALPHAINHIBITOR) |
3kv4 | PHD FINGER PROTEIN 8 (Homosapiens) | 7 / 10 | LEU A 236THR A 244HIS A 247ASP A 249LYS A 264ILE A 313HIS A 319 | OGA A5798 ( 4.8A)OGA A5798 (-3.4A)FE2 A 450 ( 3.4A)FE2 A 450 ( 2.5A)OGA A5798 (-2.8A)NoneFE2 A 450 ( 3.4A) | 0.98A | 3kcxA-3kv4A:16.7 | 3kcxA-3kv4A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLEFACTOR 1-ALPHAINHIBITOR) |
3n9o | PUTATIVEUNCHARACTERIZEDPROTEIN (Caenorhabditiselegans) | 6 / 10 | LEU A 484THR A 492HIS A 495ASP A 497LYS A 512HIS A 567 | NoneOGA A 4 (-3.7A)FE2 A 1 ( 3.3A)FE2 A 1 ( 2.6A)OGA A 4 (-3.5A)FE2 A 1 ( 3.3A) | 0.89A | 3kcxA-3n9oA:16.3 | 3kcxA-3n9oA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLEFACTOR 1-ALPHAINHIBITOR) |
3pua | PHD FINGER PROTEIN 2 (Homosapiens) | 6 / 10 | LEU A 238THR A 246HIS A 249ASP A 251LYS A 266ILE A 315 | OGA A 454 ( 3.8A)OGA A 454 (-3.8A) NI A 2 ( 3.3A) NI A 2 ( 2.5A)OGA A 454 (-3.0A)None | 0.90A | 3kcxA-3puaA:17.1 | 3kcxA-3puaA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLEFACTOR 1-ALPHAINHIBITOR) |
3pua | PHD FINGER PROTEIN 2 (Homosapiens) | 5 / 10 | LEU A 238THR A 323HIS A 249ASP A 251ILE A 315 | OGA A 454 ( 3.8A)OGA A 454 (-2.9A) NI A 2 ( 3.3A) NI A 2 ( 2.5A)None | 1.23A | 3kcxA-3puaA:17.1 | 3kcxA-3puaA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLEFACTOR 1-ALPHAINHIBITOR) |
4c8d | LYSINE-SPECIFICDEMETHYLASE 3B (Homosapiens) | 5 / 10 | THR A1557HIS A1560ASP A1562ILE A1683HIS A1689 | OGA A2722 (-3.3A) MN A2721 ( 3.3A) MN A2721 ( 3.0A)None MN A2721 ( 3.2A) | 0.50A | 3kcxA-4c8dA:14.3 | 3kcxA-4c8dA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KCX_A_CQLA1_0 (HYPOXIA-INDUCIBLEFACTOR 1-ALPHAINHIBITOR) |
4qkf | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ALKBHOMOLOG 7,MITOCHONDRIAL (Homosapiens) | 5 / 10 | LEU A 110HIS A 121ASP A 123HIS A 177ILE A 179 | OGA A 301 ( 4.6A) MN A 300 ( 3.4A) MN A 300 (-2.9A) MN A 300 ( 3.5A)None | 1.10A | 3kcxA-4qkfA:8.9 | 3kcxA-4qkfA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9F_D_CLMD221_0 (CHLORAMPHENICOLACETYLTRANSFERASE) |
4eyu | LYSINE-SPECIFICDEMETHYLASE 6B (Musmusculus) | 5 / 12 | SER A1398PHE A1454VAL A1462ALA A1412HIS A1390 | OGA A1700 (-2.8A)NoneNoneNone NI A1701 ( 3.3A) | 1.35A | 3u9fD-4eyuA:undetectable3u9fE-4eyuA:undetectable | 3u9fD-4eyuA:16.463u9fE-4eyuA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U9F_G_CLMG221_0 (CHLORAMPHENICOLACETYLTRANSFERASE) |
4eyu | LYSINE-SPECIFICDEMETHYLASE 6B (Musmusculus) | 5 / 12 | SER A1398PHE A1454VAL A1462ALA A1412HIS A1390 | OGA A1700 (-2.8A)NoneNoneNone NI A1701 ( 3.3A) | 1.32A | 3u9fG-4eyuA:undetectable3u9fH-4eyuA:undetectable | 3u9fG-4eyuA:16.463u9fH-4eyuA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UJ7_B_SAMB302_1 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE) |
2pxj | JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATIONPROTEIN 3A (Homosapiens) | 4 / 5 | TYR A 141SER A 288ASP A 61ILE A 62 | NoneOGA A5001 (-3.5A)NoneNone | 1.34A | 3uj7B-2pxjA:undetectable | 3uj7B-2pxjA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4J6D_A_TESA503_1 (CYTOCHROME P450MONOOXYGENASE) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 12 | PHE A 250GLN A 200ALA A 279ALA A 198ALA A 281 | NoneNoneOGA A 402 (-3.6A)OGA A 402 ( 4.2A)OGA A 402 ( 3.7A) | 1.08A | 4j6dA-5lunA:undetectable | 4j6dA-5lunA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4J6D_B_TESB502_1 (CYTOCHROME P450MONOOXYGENASE) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 12 | PHE A 250GLN A 200ALA A 279ALA A 198ALA A 281 | NoneNoneOGA A 402 (-3.6A)OGA A 402 ( 4.2A)OGA A 402 ( 3.7A) | 1.08A | 4j6dB-5lunA:undetectable | 4j6dB-5lunA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4JBT_A_ASDA501_1 (CYTOCHROME P450MONOOXYGENASE) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 12 | PHE A 250GLN A 200ALA A 279ALA A 198ALA A 281 | NoneNoneOGA A 402 (-3.6A)OGA A 402 ( 4.2A)OGA A 402 ( 3.7A) | 1.10A | 4jbtA-5lunA:undetectable | 4jbtA-5lunA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOT_A_CE3A205_1 (UNCHARACTERIZEDPROTEIN) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 12 | PHE A 283ARG A 321GLY A 77TYR A 126LEU A 173 | ARG A 403 ( 4.2A)NoneNoneNoneOGA A 402 (-4.5A) | 1.50A | 4kotA-5lunA:undetectable | 4kotA-5lunA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOW_A_CFXA204_1 (UNCHARACTERIZEDPROTEIN) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 12 | PHE A 283ARG A 321GLY A 77TYR A 126LEU A 173 | ARG A 403 ( 4.2A)NoneNoneNoneOGA A 402 (-4.5A) | 1.50A | 4kowA-5lunA:undetectable | 4kowA-5lunA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LRH_D_FOLD301_1 (FOLATE RECEPTORALPHA) |
3avs | LYSINE-SPECIFICDEMETHYLASE 6A (Homosapiens) | 3 / 3 | HIS A1226TRP A1194SER A1154 | NI A1503 ( 3.4A)NoneOGA A1501 (-2.7A) | 1.17A | 4lrhD-3avsA:undetectable | 4lrhD-3avsA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LRH_D_FOLD301_1 (FOLATE RECEPTORALPHA) |
4eyu | LYSINE-SPECIFICDEMETHYLASE 6B (Musmusculus) | 3 / 3 | HIS A1470TRP A1438SER A1398 | NI A1701 ( 3.1A)NoneOGA A1700 (-2.8A) | 1.16A | 4lrhD-4eyuA:undetectable | 4lrhD-4eyuA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LTW_A_486A302_1 (ANCESTRAL STEROIDRECEPTOR 2) |
4qkf | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ALKBHOMOLOG 7,MITOCHONDRIAL (Homosapiens) | 5 / 12 | LEU A 110LEU A 145ILE A 179ILE A 70ALA A 69 | OGA A 301 ( 4.6A)NoneNoneNoneNone | 1.09A | 4ltwA-4qkfA:undetectable | 4ltwA-4qkfA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O8F_B_BRLB501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) |
2pxj | JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATIONPROTEIN 3A (Homosapiens) | 5 / 12 | SER A 196LEU A 44VAL A 260PHE A 185HIS A 188 | OGA A5001 (-2.7A)NoneNoneOGA A5001 (-3.8A)FE2 A3001 ( 3.5A) | 1.22A | 4o8fB-2pxjA:undetectable | 4o8fB-2pxjA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QZT_A_RTLA201_0 (RETINOL-BINDINGPROTEIN 2) |
4bhi | GAMMA-BUTYROBETAINEDIOXYGENASE (Homosapiens) | 5 / 12 | ILE A 358TYR A 194GLN A 215LEU A 217LEU A 362 | NoneRUJ A 401 (-4.3A) ZN A 402 ( 4.2A)NoneOGA A 400 (-4.9A) | 1.43A | 4qztA-4bhiA:undetectable | 4qztA-4bhiA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YHA_B_MZMB303_1 (ALPHA-CARBONICANHYDRASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 10 | HIS A1416HIS A1881VAL A1395VAL A1900ALA A1379 | OGA A2001 (-3.9A) FE A2003 ( 3.2A)OGA A2001 ( 4.9A)OGA A2001 ( 4.9A)OGA A2001 ( 4.4A) | 1.36A | 4yhaB-5deuA:undetectable | 4yhaB-5deuA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YHA_G_MZMG303_1 (ALPHA-CARBONICANHYDRASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 12 | HIS A1416HIS A1881VAL A1395VAL A1900ALA A1379 | OGA A2001 (-3.9A) FE A2003 ( 3.2A)OGA A2001 ( 4.9A)OGA A2001 ( 4.9A)OGA A2001 ( 4.4A) | 1.49A | 4yhaG-5deuA:undetectable | 4yhaG-5deuA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5DV4_A_NMYA601_1 (CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT6-LIKE) |
6fqc | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homosapiens) | 5 / 12 | TYR A 131PRO A 171ASP A 189ASN A 287HIS A 187 | NoneNone MN A 501 ( 2.6A)OGA A 506 ( 4.6A) MN A 501 ( 3.4A) | 1.38A | 5dv4A-6fqcA:undetectable | 5dv4A-6fqcA:12.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ECM_A_LEUA602_0 (JASMONIC ACID-AMIDOSYNTHETASE JAR1) |
3pua | PHD FINGER PROTEIN 2 (Homosapiens) | 4 / 5 | THR A 246ALA A 322THR A 323HIS A 249 | OGA A 454 (-3.8A)NoneOGA A 454 (-2.9A) NI A 2 ( 3.3A) | 1.22A | 5ecmA-3puaA:undetectable | 5ecmA-3puaA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KC0_A_RBFA303_1 (RIBOFLAVINTRANSPORTER RIBU) |
4bhi | GAMMA-BUTYROBETAINEDIOXYGENASE (Homosapiens) | 5 / 12 | GLU A 230LEU A 199ALA A 294ASN A 292PHE A 291 | NoneOGA A 400 (-4.8A)NoneRUJ A 401 (-4.1A)None | 1.43A | 5kc0A-4bhiA:undetectable | 5kc0A-4bhiA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TT3_E_EZLE303_1 (ALPHA-CARBONICANHYDRASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 9 | HIS A1416HIS A1881VAL A1395VAL A1900ALA A1379 | OGA A2001 (-3.9A) FE A2003 ( 3.2A)OGA A2001 ( 4.9A)OGA A2001 ( 4.9A)OGA A2001 ( 4.4A) | 1.42A | 5tt3E-5deuA:undetectable | 5tt3E-5deuA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TT3_G_EZLG303_1 (ALPHA-CARBONICANHYDRASE) |
5deu | METHYLCYTOSINEDIOXYGENASE TET2,CHIMERIC CONSTRUCT (Homosapiens) | 5 / 9 | HIS A1416HIS A1881VAL A1395VAL A1900ALA A1379 | OGA A2001 (-3.9A) FE A2003 ( 3.2A)OGA A2001 ( 4.9A)OGA A2001 ( 4.9A)OGA A2001 ( 4.4A) | 1.46A | 5tt3G-5deuA:undetectable | 5tt3G-5deuA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YF0_A_SAMA505_0 (CARNOSINEN-METHYLTRANSFERASE) |
2rds | 1-DEOXYPENTALENICACID 11-BETAHYDROXYLASE FE(II)/ALPHA-KETOGLUTARATE DEPENDENTHYDROXYLASE (Streptomycesavermitilis) | 5 / 12 | GLY A 164GLY A 165ASN A 231SER A 242TYR A 8 | NoneNoneNoneOGA A 268 ( 4.5A)None | 1.24A | 5yf0A-2rdsA:undetectable | 5yf0A-2rdsA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DK1_C_GM4C301_0 (SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1) |
5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) | 5 / 11 | ALA A 281TYR A 318ASP A 91GLU A 84THR A 97 | OGA A 402 ( 3.7A)NoneARG A 403 ( 4.7A)ARG A 403 (-3.5A)None | 1.22A | 6dk1C-5lunA:4.3 | 6dk1C-5lunA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HU9_S_PCFS603_0 (CYTOCHROME B-C1COMPLEX SUBUNIT 8CYTOCHROME C OXIDASEPOLYPEPTIDE 5A,MITOCHONDRIAL) |
3avs | LYSINE-SPECIFICDEMETHYLASE 6A (Homosapiens) | 4 / 7 | GLN A1133GLY A1128VAL A1268SER A1154 | NoneNoneNoneOGA A1501 (-2.7A) | 0.80A | 6hu9S-3avsA:undetectable6hu9q-3avsA:undetectable | 6hu9S-3avsA:10.126hu9q-3avsA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HU9_S_PCFS603_0 (CYTOCHROME B-C1COMPLEX SUBUNIT 8CYTOCHROME C OXIDASEPOLYPEPTIDE 5A,MITOCHONDRIAL) |
4eyu | LYSINE-SPECIFICDEMETHYLASE 6B (Musmusculus) | 4 / 7 | GLN A1377GLY A1372VAL A1512SER A1398 | NoneNoneNoneOGA A1700 (-2.8A) | 0.89A | 6hu9S-4eyuA:undetectable6hu9q-4eyuA:undetectable | 6hu9S-4eyuA:10.746hu9q-4eyuA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MA7_A_TPFA602_0 (CYTOCHROME P450 3A4) |
4qkf | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ALKBHOMOLOG 7,MITOCHONDRIAL (Homosapiens) | 4 / 7 | ARG A 191ARG A 197ALA A 114ILE A 179 | NoneOGA A 301 (-3.0A)NoneNone | 0.95A | 6ma7A-4qkfA:undetectable | 6ma7A-4qkfA:13.76 |