SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OGA'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo
sapiens)
5 / 12 HIS A 202
ASP A 261
ALA A 193
HIS A 347
ASP A 204
ZN  A 402 ( 3.3A)
RUJ  A 401 ( 4.7A)
OGA  A 400 (-3.1A)
ZN  A 402 ( 3.3A)
ZN  A 402 (-2.6A)
1.26A 1a4lA-4bhiA:
undetectable
1a4lA-4bhiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo
sapiens)
5 / 12 HIS A 202
ASP A 261
ALA A 193
HIS A 347
ASP A 204
ZN  A 402 ( 3.3A)
RUJ  A 401 ( 4.7A)
OGA  A 400 (-3.1A)
ZN  A 402 ( 3.3A)
ZN  A 402 (-2.6A)
1.25A 1a4lC-4bhiA:
undetectable
1a4lC-4bhiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE

(Streptomyces
avermitilis)
4 / 5 THR A 151
ASP A 139
HIS A 137
HIS A 226
OGA  A 268 (-3.8A)
FE  A   1 ( 2.6A)
FE  A   1 (-3.4A)
FE  A   1 ( 3.4A)
1.16A 1ei6A-2rdsA:
undetectable
1ei6A-2rdsA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo
sapiens)
4 / 8 ASP A 721
SER A 722
SER A 563
ARG A 662
OGA  A 802 ( 4.8A)
None
None
None
0.95A 1meiA-5jz8A:
undetectable
1meiA-5jz8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
4 / 7 ARG A 277
ALA A 279
ILE A 186
ILE A  95
OGA  A 402 (-2.7A)
OGA  A 402 (-3.6A)
ARG  A 403 (-4.7A)
None
0.79A 1oniD-5lunA:
undetectable
1oniF-5lunA:
undetectable
1oniD-5lunA:
17.01
1oniF-5lunA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3pua PHD FINGER PROTEIN 2
(Homo
sapiens)
5 / 12 THR A 325
TYR A 259
PHE A 268
SER A 244
ALA A 333
None
OGA  A 454 (-4.6A)
None
None
EDO  A   9 ( 3.9A)
1.29A 1q23A-3puaA:
undetectable
1q23B-3puaA:
undetectable
1q23A-3puaA:
18.25
1q23B-3puaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis)
5 / 12 LEU A 218
HIS A 137
ASP A 139
SER A 172
PHE A 220
None
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
None
OGA  A 268 (-4.9A)
1.46A 1uobA-2rdsA:
9.9
1uobA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida)
5 / 12 HIS A 124
ASP A 126
HIS A 183
SER A 194
VAL A 139
MN  A 401 ( 3.3A)
MN  A 401 ( 2.6A)
MN  A 401 ( 3.3A)
OGA  A 402 ( 3.7A)
OGA  A 402 ( 4.9A)
1.44A 1uobA-4j25A:
10.3
1uobA-4j25A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida)
5 / 12 HIS A 124
ASP A 126
LEU A 154
HIS A 183
SER A 194
MN  A 401 ( 3.3A)
MN  A 401 ( 2.6A)
OGA  A 402 (-3.7A)
MN  A 401 ( 3.3A)
OGA  A 402 ( 3.7A)
0.61A 1uobA-4j25A:
10.3
1uobA-4j25A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi)
5 / 12 HIS A 229
ASP A 231
LEU A 253
HIS A 279
VAL A 293
MN  A 401 ( 3.4A)
MN  A 401 ( 2.7A)
OGA  A 413 (-3.8A)
MN  A 401 ( 3.4A)
OGA  A 413 (-4.9A)
0.68A 1uobA-4lt5A:
8.2
1uobA-4lt5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 12 HIS A1382
ASP A1384
HIS A1881
SER A1898
VAL A1900
FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
0.61A 1uobA-5deuA:
7.6
1uobA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 12 SER A1286
HIS A1881
LEU A1872
SER A1898
VAL A1900
None
FE  A2003 ( 3.2A)
None
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
1.50A 1uobA-5deuA:
7.6
1uobA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 12 HIS A 189
ASP A 191
LEU A 206
HIS A 268
PHE A 283
FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
OGA  A 402 (-3.5A)
FE  A 401 ( 3.2A)
ARG  A 403 ( 4.2A)
0.50A 1uobA-5lunA:
21.1
1uobA-5lunA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis)
5 / 11 HIS A 137
ASP A 139
HIS A 226
ARG A 240
SER A 242
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
FE  A   1 ( 3.4A)
OGA  A 268 (-2.9A)
OGA  A 268 ( 4.5A)
1.03A 1uofA-2rdsA:
5.7
1uofA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis)
5 / 11 HIS A 137
ASP A 139
THR A 151
HIS A 226
SER A 242
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
OGA  A 268 (-3.8A)
FE  A   1 ( 3.4A)
OGA  A 268 ( 4.5A)
0.64A 1uofA-2rdsA:
5.7
1uofA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis)
5 / 11 PHE A  73
HIS A 137
ASP A 139
THR A 151
HIS A 226
None
FE  A   1 (-3.4A)
FE  A   1 ( 2.6A)
OGA  A 268 (-3.8A)
FE  A   1 ( 3.4A)
0.88A 1uofA-2rdsA:
5.7
1uofA-2rdsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida)
6 / 11 HIS A 124
ASP A 126
HIS A 183
VAL A 185
SER A 194
VAL A 139
MN  A 401 ( 3.3A)
MN  A 401 ( 2.6A)
MN  A 401 ( 3.3A)
None
OGA  A 402 ( 3.7A)
OGA  A 402 ( 4.9A)
1.36A 1uofA-4j25A:
9.4
1uofA-4j25A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi)
5 / 11 HIS A 229
ASP A 231
HIS A 279
VAL A 281
VAL A 293
MN  A 401 ( 3.4A)
MN  A 401 ( 2.7A)
MN  A 401 ( 3.4A)
OGA  A 413 (-4.8A)
OGA  A 413 (-4.9A)
0.60A 1uofA-4lt5A:
2.7
1uofA-4lt5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 11 HIS A1382
ASP A1384
ARG A1896
SER A1898
VAL A1900
FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
OGA  A2001 (-2.9A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
1.00A 1uofA-5deuA:
7.1
1uofA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 11 HIS A1382
ASP A1384
HIS A1881
SER A1898
VAL A1900
FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
0.79A 1uofA-5deuA:
7.1
1uofA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 11 HIS A1382
THR A1393
HIS A1881
SER A1898
VAL A1900
FE  A2003 (-3.3A)
CL  A2007 (-4.5A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
0.74A 1uofA-5deuA:
7.1
1uofA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo
sapiens)
5 / 11 HIS A 679
HIS A 725
VAL A 727
ARG A 735
SER A 668
MN  A 801 ( 3.4A)
MN  A 801 ( 3.4A)
OGA  A 802 ( 4.9A)
OGA  A 802 (-2.2A)
OGA  A 802 (-2.5A)
1.18A 1uofA-5jz8A:
6.9
1uofA-5jz8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
3 / 3 LYS A 204
ASP A 189
ASN A 197
OGA  A 506 (-2.9A)
MN  A 501 ( 2.6A)
OGA  A 506 (-3.6A)
1.13A 2bm9A-6fqcA:
undetectable
2bm9A-6fqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
2xdv MYC-INDUCED NUCLEAR
ANTIGEN

(Homo
sapiens)
5 / 12 LEU A 198
PHE A 234
LEU A 226
ILE A 187
ALA A 242
None
None
None
None
OGA  A 601 ( 4.2A)
1.18A 2bxpA-2xdvA:
undetectable
2bxpA-2xdvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
2xdv MYC-INDUCED NUCLEAR
ANTIGEN

(Homo
sapiens)
5 / 12 SER A 257
PRO A 140
THR A 255
VAL A 254
ILE A 150
None
None
OGA  A 601 (-3.0A)
None
None
1.42A 2fj1A-2xdvA:
undetectable
2fj1A-2xdvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
COAGULATION FACTOR X

(Homo
sapiens)
5 / 12 GLY A 663
ASP A 741
PHE A 719
GLY A 681
ASP B 103
None
None
OGA  A 802 (-4.9A)
None
OGA  A 802 ( 3.2A)
1.25A 2fqyA-5jz8A:
undetectable
2fqyA-5jz8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans)
4 / 8 GLY A 579
LEU A 484
LEU A 423
PHE A 498
None
None
OGA  A   4 (-4.4A)
None
0.73A 2vctA-3n9oA:
3.5
2vctA-3n9oA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans)
4 / 8 GLY A 579
LEU A 484
LEU A 423
PHE A 498
None
None
OGA  A   4 (-4.4A)
None
0.75A 2vctB-3n9oA:
5.0
2vctB-3n9oA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)
3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)
4 / 6 ASP A 249
HIS A 319
TYR A 257
ASN A 189
FE2  A 450 ( 2.5A)
FE2  A 450 ( 3.4A)
OGA  A5798 (-4.2A)
OGA  A5798 (-3.7A)
1.14A 2zs9A-3kv4A:
undetectable
2zs9A-3kv4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans)
4 / 6 ASP A 497
HIS A 567
TYR A 505
ASN A 421
FE2  A   1 ( 2.6A)
FE2  A   1 ( 3.3A)
OGA  A   4 (-4.1A)
OGA  A   4 (-4.0A)
1.16A 2zs9A-3n9oA:
undetectable
2zs9A-3n9oA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi)
4 / 6 VAL A 293
ASP A 234
HIS A 297
ASN A 214
OGA  A 413 (-4.9A)
None
None
OGA  A 413 (-3.3A)
1.36A 2zs9A-4lt5A:
undetectable
2zs9A-4lt5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi)
5 / 11 VAL A 293
ASP A 234
HIS A 297
ILE A 225
ASN A 214
OGA  A 413 (-4.9A)
None
None
OGA  A 413 (-4.1A)
OGA  A 413 (-3.3A)
1.49A 3avoA-4lt5A:
undetectable
3avoA-4lt5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
4 / 8 ASP A1376
TYR A1245
SER A1898
ILE A1897
None
None
OGA  A2001 (-2.7A)
None
0.89A 3ihzB-5deuA:
undetectable
3ihzB-5deuA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)
7 / 10 LEU A 236
THR A 244
HIS A 247
ASP A 249
LYS A 264
ILE A 313
HIS A 319
OGA  A5798 ( 4.8A)
OGA  A5798 (-3.4A)
FE2  A 450 ( 3.4A)
FE2  A 450 ( 2.5A)
OGA  A5798 (-2.8A)
None
FE2  A 450 ( 3.4A)
0.98A 3kcxA-3kv4A:
16.7
3kcxA-3kv4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans)
6 / 10 LEU A 484
THR A 492
HIS A 495
ASP A 497
LYS A 512
HIS A 567
None
OGA  A   4 (-3.7A)
FE2  A   1 ( 3.3A)
FE2  A   1 ( 2.6A)
OGA  A   4 (-3.5A)
FE2  A   1 ( 3.3A)
0.89A 3kcxA-3n9oA:
16.3
3kcxA-3n9oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
3pua PHD FINGER PROTEIN 2
(Homo
sapiens)
6 / 10 LEU A 238
THR A 246
HIS A 249
ASP A 251
LYS A 266
ILE A 315
OGA  A 454 ( 3.8A)
OGA  A 454 (-3.8A)
NI  A   2 ( 3.3A)
NI  A   2 ( 2.5A)
OGA  A 454 (-3.0A)
None
0.90A 3kcxA-3puaA:
17.1
3kcxA-3puaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
3pua PHD FINGER PROTEIN 2
(Homo
sapiens)
5 / 10 LEU A 238
THR A 323
HIS A 249
ASP A 251
ILE A 315
OGA  A 454 ( 3.8A)
OGA  A 454 (-2.9A)
NI  A   2 ( 3.3A)
NI  A   2 ( 2.5A)
None
1.23A 3kcxA-3puaA:
17.1
3kcxA-3puaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B

(Homo
sapiens)
5 / 10 THR A1557
HIS A1560
ASP A1562
ILE A1683
HIS A1689
OGA  A2722 (-3.3A)
MN  A2721 ( 3.3A)
MN  A2721 ( 3.0A)
None
MN  A2721 ( 3.2A)
0.50A 3kcxA-4c8dA:
14.3
3kcxA-4c8dA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo
sapiens)
5 / 10 LEU A 110
HIS A 121
ASP A 123
HIS A 177
ILE A 179
OGA  A 301 ( 4.6A)
MN  A 300 ( 3.4A)
MN  A 300 (-2.9A)
MN  A 300 ( 3.5A)
None
1.10A 3kcxA-4qkfA:
8.9
3kcxA-4qkfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus
musculus)
5 / 12 SER A1398
PHE A1454
VAL A1462
ALA A1412
HIS A1390
OGA  A1700 (-2.8A)
None
None
None
NI  A1701 ( 3.3A)
1.35A 3u9fD-4eyuA:
undetectable
3u9fE-4eyuA:
undetectable
3u9fD-4eyuA:
16.46
3u9fE-4eyuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus
musculus)
5 / 12 SER A1398
PHE A1454
VAL A1462
ALA A1412
HIS A1390
OGA  A1700 (-2.8A)
None
None
None
NI  A1701 ( 3.3A)
1.32A 3u9fG-4eyuA:
undetectable
3u9fH-4eyuA:
undetectable
3u9fG-4eyuA:
16.46
3u9fH-4eyuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo
sapiens)
4 / 5 TYR A 141
SER A 288
ASP A  61
ILE A  62
None
OGA  A5001 (-3.5A)
None
None
1.34A 3uj7B-2pxjA:
undetectable
3uj7B-2pxjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 12 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
1.08A 4j6dA-5lunA:
undetectable
4j6dA-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 12 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
1.08A 4j6dB-5lunA:
undetectable
4j6dB-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 12 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
1.10A 4jbtA-5lunA:
undetectable
4jbtA-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 12 PHE A 283
ARG A 321
GLY A  77
TYR A 126
LEU A 173
ARG  A 403 ( 4.2A)
None
None
None
OGA  A 402 (-4.5A)
1.50A 4kotA-5lunA:
undetectable
4kotA-5lunA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 12 PHE A 283
ARG A 321
GLY A  77
TYR A 126
LEU A 173
ARG  A 403 ( 4.2A)
None
None
None
OGA  A 402 (-4.5A)
1.50A 4kowA-5lunA:
undetectable
4kowA-5lunA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo
sapiens)
3 / 3 HIS A1226
TRP A1194
SER A1154
NI  A1503 ( 3.4A)
None
OGA  A1501 (-2.7A)
1.17A 4lrhD-3avsA:
undetectable
4lrhD-3avsA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus
musculus)
3 / 3 HIS A1470
TRP A1438
SER A1398
NI  A1701 ( 3.1A)
None
OGA  A1700 (-2.8A)
1.16A 4lrhD-4eyuA:
undetectable
4lrhD-4eyuA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo
sapiens)
5 / 12 LEU A 110
LEU A 145
ILE A 179
ILE A  70
ALA A  69
OGA  A 301 ( 4.6A)
None
None
None
None
1.09A 4ltwA-4qkfA:
undetectable
4ltwA-4qkfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo
sapiens)
5 / 12 SER A 196
LEU A  44
VAL A 260
PHE A 185
HIS A 188
OGA  A5001 (-2.7A)
None
None
OGA  A5001 (-3.8A)
FE2  A3001 ( 3.5A)
1.22A 4o8fB-2pxjA:
undetectable
4o8fB-2pxjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo
sapiens)
5 / 12 ILE A 358
TYR A 194
GLN A 215
LEU A 217
LEU A 362
None
RUJ  A 401 (-4.3A)
ZN  A 402 ( 4.2A)
None
OGA  A 400 (-4.9A)
1.43A 4qztA-4bhiA:
undetectable
4qztA-4bhiA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 10 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
1.36A 4yhaB-5deuA:
undetectable
4yhaB-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 12 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
1.49A 4yhaG-5deuA:
undetectable
4yhaG-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo
sapiens)
5 / 12 TYR A 131
PRO A 171
ASP A 189
ASN A 287
HIS A 187
None
None
MN  A 501 ( 2.6A)
OGA  A 506 ( 4.6A)
MN  A 501 ( 3.4A)
1.38A 5dv4A-6fqcA:
undetectable
5dv4A-6fqcA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3pua PHD FINGER PROTEIN 2
(Homo
sapiens)
4 / 5 THR A 246
ALA A 322
THR A 323
HIS A 249
OGA  A 454 (-3.8A)
None
OGA  A 454 (-2.9A)
NI  A   2 ( 3.3A)
1.22A 5ecmA-3puaA:
undetectable
5ecmA-3puaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo
sapiens)
5 / 12 GLU A 230
LEU A 199
ALA A 294
ASN A 292
PHE A 291
None
OGA  A 400 (-4.8A)
None
RUJ  A 401 (-4.1A)
None
1.43A 5kc0A-4bhiA:
undetectable
5kc0A-4bhiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 9 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
1.42A 5tt3E-5deuA:
undetectable
5tt3E-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo
sapiens)
5 / 9 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
1.46A 5tt3G-5deuA:
undetectable
5tt3G-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)
2rds 1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE
FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE

(Streptomyces
avermitilis)
5 / 12 GLY A 164
GLY A 165
ASN A 231
SER A 242
TYR A   8
None
None
None
OGA  A 268 ( 4.5A)
None
1.24A 5yf0A-2rdsA:
undetectable
5yf0A-2rdsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi)
5 / 11 ALA A 281
TYR A 318
ASP A  91
GLU A  84
THR A  97
OGA  A 402 ( 3.7A)
None
ARG  A 403 ( 4.7A)
ARG  A 403 (-3.5A)
None
1.22A 6dk1C-5lunA:
4.3
6dk1C-5lunA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo
sapiens)
4 / 7 GLN A1133
GLY A1128
VAL A1268
SER A1154
None
None
None
OGA  A1501 (-2.7A)
0.80A 6hu9S-3avsA:
undetectable
6hu9q-3avsA:
undetectable
6hu9S-3avsA:
10.12
6hu9q-3avsA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B

(Mus
musculus)
4 / 7 GLN A1377
GLY A1372
VAL A1512
SER A1398
None
None
None
OGA  A1700 (-2.8A)
0.89A 6hu9S-4eyuA:
undetectable
6hu9q-4eyuA:
undetectable
6hu9S-4eyuA:
10.74
6hu9q-4eyuA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)
4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL

(Homo
sapiens)
4 / 7 ARG A 191
ARG A 197
ALA A 114
ILE A 179
None
OGA  A 301 (-3.0A)
None
None
0.95A 6ma7A-4qkfA:
undetectable
6ma7A-4qkfA:
13.76