SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OCT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4pr7 OLIGOGALACTURONATE-S
PECIFIC PORIN KDGM
(Dickeya
dadantii) 		4 / 6 SER A  75
ARG A 112
GLY A  79
GLU A  61
 None
ADA  A 309 ( 3.7A)
OCT  A 304 (-4.7A)
ADA  A 309 ( 4.9A)
 1.15A 3k9fA-4pr7A:
undetectable
3k9fB-4pr7A:
undetectable
3k9fD-4pr7A:
undetectable		 3k9fA-4pr7A:
19.11
3k9fB-4pr7A:
19.11
3k9fD-4pr7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2wjr PROBABLE
N-ACETYLNEURAMINIC
ACID OUTER MEMBRANE
CHANNEL PROTEIN NANC
(Escherichia
coli) 		4 / 4 GLY A 103
TYR A 133
GLY A 132
ASP A 131
 OCT  A1219 (-4.5A)
None
OCT  A1219 ( 4.0A)
None
 1.25A 3kl3A-2wjrA:
undetectable		 3kl3A-2wjrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2xe5 OUTER MEMBRANE PORIN
C
(Escherichia
coli) 		5 / 12 ALA A 193
TYR A 218
SER A 196
SER A 195
GLY A 178
 None
OCT  A1347 (-4.6A)
None
None
None
 1.01A 4mmdB-2xe5A:
undetectable		 4mmdB-2xe5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A 423
ILE A 391
GLY A 387
LEU A 252
ALA A 247
 None
None
None
OCT  A 502 ( 4.9A)
None
 1.04A 5h5fA-1kplA:
undetectable		 5h5fA-1kplA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 9 TYR A 110
ALA A 310
THR A 314
CYH A 448
LEU A 485
 HEM  A 600 (-4.4A)
HEM  A 600 ( 3.2A)
HEM  A 600 ( 3.7A)
HEM  A 600 (-2.1A)
OCT  A 601 ( 4.9A)
 0.86A 6ay6A-6c93A:
36.6		 6ay6A-6c93A:
11.18