SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OCS'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BSX_A_T3A1_1 (PROTEIN (THYROID HORMONE RECEPTOR BETA))	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 12	ILE A  20 ARG A 179 LEU A  14 LEU A  85 ILE A  87	None SO4  A 409 (-4.1A) None None OCS  A  88 ( 4.0A)	1.04A	1bsxA-1o1yA: 0.0	1bsxA-1o1yA: 23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BSX_B_T3B2_1 (PROTEIN (THYROID HORMONE RECEPTOR BETA))	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 12	ILE A  20 ARG A 179 LEU A  14 LEU A  85 ILE A  87	None SO4  A 409 (-4.1A) None None OCS  A  88 ( 4.0A)	1.04A	1bsxB-1o1yA: 0.0	1bsxB-1o1yA: 23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DRA_B_MTXB361_1 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.08A	1draB-3shoA: undetectable	1draB-3shoA: 19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DSS_G_CCSG149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	4 / 7	ASN O 388 TYR O 392 ASN O 227 TYR O 386	NAD  O 501 (-3.9A) NAD  O 501 (-2.7A) OCS  O 224 ( 4.8A) OCS  O 224 ( 4.0A)	0.93A	1dssG-5c7oO: 53.6	1dssG-5c7oO: 66.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DSS_G_CCSG149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	7 / 7	SER O 223 THR O 225 ASN O 227 CYH O 228 TYR O 386 ASN O 388 TYR O 392	OCS  O 224 ( 3.4A) OCS  O 224 ( 4.2A) OCS  O 224 ( 4.8A) None OCS  O 224 ( 4.0A) NAD  O 501 (-3.9A) NAD  O 501 (-2.7A)	0.12A	1dssG-5c7oO: 53.6	1dssG-5c7oO: 66.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSS_G_CCSG149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	4 / 7	ASN A 314 TYR A 318 ASN A 152 TYR A 312	NAD  A 401 (-3.7A) NAD  A 401 (-3.5A) None OCS  A 149 ( 4.1A)	0.93A	1dssG-5ur0A: 51.6	1dssG-5ur0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSS_G_CCSG149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	7 / 7	SER A 148 THR A 150 ASN A 152 CYH A 153 TYR A 312 ASN A 314 TYR A 318	OCS  A 149 ( 3.5A) OCS  A 149 ( 3.8A) None None OCS  A 149 ( 4.1A) NAD  A 401 (-3.7A) NAD  A 401 (-3.5A)	0.18A	1dssG-5ur0A: 51.6	1dssG-5ur0A: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DSS_R_CCSR149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	4 / 8	ASN O 388 TYR O 392 ASN O 227 TYR O 386	NAD  O 501 (-3.9A) NAD  O 501 (-2.7A) OCS  O 224 ( 4.8A) OCS  O 224 ( 4.0A)	0.92A	1dssR-5c7oO: 53.5	1dssR-5c7oO: 66.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DSS_R_CCSR149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	8 / 8	SER O 223 THR O 225 ASN O 227 CYH O 228 HIS O 251 TYR O 386 ASN O 388 TYR O 392	OCS  O 224 ( 3.4A) OCS  O 224 ( 4.2A) OCS  O 224 ( 4.8A) None OCS  O 224 ( 3.9A) OCS  O 224 ( 4.0A) NAD  O 501 (-3.9A) NAD  O 501 (-2.7A)	0.31A	1dssR-5c7oO: 53.5	1dssR-5c7oO: 66.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSS_R_CCSR149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	4 / 8	ASN A 314 TYR A 318 ASN A 152 TYR A 312	NAD  A 401 (-3.7A) NAD  A 401 (-3.5A) None OCS  A 149 ( 4.1A)	0.92A	1dssR-5ur0A: 51.4	1dssR-5ur0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSS_R_CCSR149_0 (D-GLYCERALDEHYDE-3-P HOSPHATE-DEHYDROGENA SE)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	8 / 8	SER A 148 THR A 150 ASN A 152 CYH A 153 HIS A 176 TYR A 312 ASN A 314 TYR A 318	OCS  A 149 ( 3.5A) OCS  A 149 ( 3.8A) None None OCS  A 149 ( 4.0A) OCS  A 149 ( 4.1A) NAD  A 401 (-3.7A) NAD  A 401 (-3.5A)	0.33A	1dssR-5ur0A: 51.4	1dssR-5ur0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DVT_A_FLPA125_1 (TRANSTHYRETIN)	1v3y	PEPTIDE DEFORMYLASE (Thermus thermophilus)	4 / 8	ALA A  47 LEU A 108 LEU A 105 SER A 104	None None OCS  A 102 ( 4.4A) OCS  A 102 ( 3.3A)	0.91A	1dvtA-1v3yA: undetectable 1dvtB-1v3yA: undetectable	1dvtA-1v3yA: 20.81 1dvtB-1v3yA: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EI6_D_PPFD412_1 (PHOSPHONOACETATE HYDROLASE)	3ze7	PERIPLASMIC [NIFESE] HYDROGENASE, LARGE SUBUNIT, SELENOCYSTEINE-CONTA INING (Desulfovibrio vulgaris)	4 / 8	PHE B  55 HIS B 427 ILE B  74 HIS B  82	None None OCS  B  75 ( 3.9A) FCO  B 500 (-4.3A)	1.00A	1ei6D-3ze7B: undetectable	1ei6D-3ze7B: 24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_H_ACTH3006_0 (BETA-CARBONIC ANHYDRASE)	3ze7	PERIPLASMIC [NIFESE] HYDROGENASE, LARGE SUBUNIT, SELENOCYSTEINE-CONTA INING (Desulfovibrio vulgaris)	4 / 6	CYH B  78 VAL B  77 HIS B  82 CYH B 492	FCO  B 500 (-2.2A) OCS  B  75 ( 3.3A) FCO  B 500 (-4.3A) FCO  B 500 ( 2.3A)	1.41A	1ekjG-3ze7B: undetectable 1ekjH-3ze7B: undetectable	1ekjG-3ze7B: 20.42 1ekjH-3ze7B: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H4O_B_BEZB1162_0 (PEROXIREDOXIN 5)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 8	PRO A  39 THR A  43 PRO A  44 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 2.3A)	0.48A	1h4oB-5xbqA: 18.2	1h4oB-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H4O_G_BEZG1162_0 (PEROXIREDOXIN 5)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 8	PRO A  39 THR A  43 PRO A  44 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 2.3A)	0.42A	1h4oG-5xbqA: 18.1	1h4oG-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT7_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	2f1k	PREPHENATE DEHYDROGENASE (Synechocystis sp. PCC 6803)	5 / 11	LEU A 155 ALA A 115 VAL A 154 LEU A  19 HIS A 112	None OMT  A 114 (-3.1A) OCS  A 150 ( 3.9A) None OMT  A 114 ( 3.9A)	1.42A	1kt7A-2f1kA: undetectable	1kt7A-2f1kA: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OC3_A_BEZA201_0 (PEROXIREDOXIN 5)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 8	PRO A  39 THR A  43 PRO A  44 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 2.3A)	0.52A	1oc3A-5xbqA: 18.0	1oc3A-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZZ_A_ACTA421_0 (ACLACINOMYCIN-10-HYD ROXYLASE)	1o1x	RIBOSE-5-PHOSPHATE ISOMERASE RPIB (Thermotoga maritima)	5 / 8	TYR A  42 GLY A  66 GLY A  68 GLY A  70 MET A  71	OCS  A  65 ( 3.8A) OCS  A  65 ( 2.4A) OCS  A  65 ( 2.9A) OCS  A  65 ( 3.1A) OCS  A  65 ( 4.8A)	1.50A	1qzzA-1o1xA: 2.9	1qzzA-1o1xA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RA3_A_MTXA161_1 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.05A	1ra3A-3shoA: undetectable	1ra3A-3shoA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS7_A_ACTA860_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5jmu	PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE ([Eubacterium] rectale)	4 / 5	GLY A 401 ILE A 402 VAL A 494 SER A 395	OCS  A 399 ( 4.2A) OCS  A 399 ( 3.6A) None None	1.20A	1rs7A-5jmuA: undetectable	1rs7A-5jmuA: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SGU_B_MK1B2632_2 (POL POLYPROTEIN)	4fdy	SIMILAR TO LIPOPROTEIN, NLP/P60 FAMILY (Staphylococcus aureus)	5 / 12	GLY A 314 ALA A 313 ILE A 250 ILE A 303 ALA A 265	None OCS  A 246 ( 3.5A) OCS  A 246 ( 4.2A) None OCS  A 246 ( 4.0A)	0.84A	1sguB-4fdyA: undetectable	1sguB-4fdyA: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SH9_B_RITB301_1 (POL POLYPROTEIN)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 8	ALA A 167 ILE A  77 ILE A  74 GLY A  90 ILE A  87	None None None OCS  A  88 ( 3.9A) OCS  A  88 ( 4.0A)	1.23A	1sh9A-1o1yA: undetectable	1sh9A-1o1yA: 18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	7 / 12	PRO A  87 GLY A 111 SER A 130 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) None OCS  A  86 ( 3.8A) None None None None	0.66A	1uakA-3ky7A: 19.8	1uakA-3ky7A: 43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	7 / 12	PRO A  87 SER A 130 VAL A 135 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) OCS  A  86 ( 3.8A) None None None None None	0.70A	1uakA-3ky7A: 19.8	1uakA-3ky7A: 43.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AZQ_A_PCFA954_0 (CATECHOL 1,2-DIOXYGENASE)	5txw	PEPTIDASE (Thermococcus thioreducens)	5 / 9	LEU A 165 ALA A  97 LEU A  67 GLU A  15 LEU A 154	None None None OCS  A 100 ( 2.4A) None	1.44A	2azqA-5txwA: undetectable	2azqA-5txwA: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_D_SAMD301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	2p8e	PPM1B BETA ISOFORM VARIANT 6 (Homo sapiens)	3 / 3	LYS A 243 ASP A 114 ASP A  60	OCS  A 242 (-3.0A) None MG  A 306 (-2.5A)	0.99A	2br4D-2p8eA: undetectable	2br4D-2p8eA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	4rpa	PROBABLE MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE (Staphylococcus aureus)	5 / 12	LEU A 109 ILE A  95 VAL A  74 HIS A  76 ALA A  35	OCS  A 110 ( 3.6A) None None None None	1.12A	2g72B-4rpaA: undetectable	2g72B-4rpaA: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H77_A_T3A1_1 (THRA PROTEIN)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 12	ILE A  20 ARG A 179 LEU A  14 LEU A  85 ILE A  87	None SO4  A 409 (-4.1A) None None OCS  A  88 ( 4.0A)	1.02A	2h77A-1o1yA: 0.0	2h77A-1o1yA: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_A_SAMA201_0 (UPF0066 PROTEIN AF_0241)	2hl9	UBIQUITIN-LIKE-SPECI FIC PROTEASE 1 (Saccharomyces cerevisiae)	5 / 12	ASP A 531 PRO A 507 GLY A 581 LEU A 449 LEU A 510	None None OCS  A 580 ( 2.4A) None None	1.34A	2nv4A-2hl9A: undetectable	2nv4A-2hl9A: 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PGF_A_ADNA501_1 (ADENOSINE DEAMINASE)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	5 / 12	PHE A  90 ILE A  97 GLY A  86 HIS A 129 HIS A 133	OCS  A  87 ( 4.4A) None OCS  A  87 ( 2.4A) OCS  A  87 ( 3.9A) OCS  A  87 ( 4.0A)	1.20A	2pgfA-1lmeA: undetectable	2pgfA-1lmeA: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PGR_A_DCFA501_1 (ADENOSINE DEAMINASE)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	5 / 12	PHE A  90 ILE A  97 GLY A  86 HIS A 129 HIS A 133	OCS  A  87 ( 4.4A) None OCS  A  87 ( 2.4A) OCS  A  87 ( 3.9A) OCS  A  87 ( 4.0A)	1.17A	2pgrA-1lmeA: undetectable	2pgrA-1lmeA: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QR2_B_VK3B235_1 (PROTEIN (QUINONE REDUCTASE TYPE 2))	2wfi	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G (Homo sapiens)	4 / 6	PHE A  26 PHE A  40 GLY A  76 GLY A  77	None None OCS  A  63 ( 4.5A) OCS  A  63 ( 3.2A)	0.80A	2qr2A-2wfiA: undetectable 2qr2B-2wfiA: undetectable	2qr2A-2wfiA: 24.57 2qr2B-2wfiA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QR2_B_VK3B236_1 (PROTEIN (QUINONE REDUCTASE TYPE 2))	2wfi	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G (Homo sapiens)	4 / 5	GLY A  76 GLY A  77 PHE A  26 PHE A  40	OCS  A  63 ( 4.5A) OCS  A  63 ( 3.2A) None None	0.74A	2qr2A-2wfiA: undetectable 2qr2B-2wfiA: undetectable	2qr2A-2wfiA: 24.57 2qr2B-2wfiA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QX4_A_ML1A233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	2wfi	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G (Homo sapiens)	4 / 8	PHE A  26 PHE A  40 GLY A  76 GLY A  77	None None OCS  A  63 ( 4.5A) OCS  A  63 ( 3.2A)	0.70A	2qx4A-2wfiA: undetectable 2qx4B-2wfiA: undetectable	2qx4A-2wfiA: 24.57 2qx4B-2wfiA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QX6_A_ML1A233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	2wfi	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G (Homo sapiens)	4 / 6	PHE A  26 PHE A  40 GLY A  76 GLY A  77	None None OCS  A  63 ( 4.5A) OCS  A  63 ( 3.2A)	0.70A	2qx6A-2wfiA: undetectable 2qx6B-2wfiA: undetectable	2qx6A-2wfiA: 24.57 2qx6B-2wfiA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_B_MK1B902_1 (PROTEASE)	5txw	PEPTIDASE (Thermococcus thioreducens)	5 / 12	VAL A  76 GLY A  70 GLY A  69 ILE A  99 ILE A 105	None OCS  A 100 ( 3.7A) OCS  A 100 ( 3.0A) OCS  A 100 ( 3.7A) None	0.98A	2r5pA-5txwA: undetectable	2r5pA-5txwA: 19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_D_MK1D902_1 (PROTEASE)	5txw	PEPTIDASE (Thermococcus thioreducens)	5 / 12	VAL A  76 GLY A  70 GLY A  69 ILE A  99 ILE A 105	None OCS  A 100 ( 3.7A) OCS  A 100 ( 3.0A) OCS  A 100 ( 3.7A) None	0.98A	2r5pC-5txwA: undetectable	2r5pC-5txwA: 19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2RLC_A_GLYA333_0 (CHOLOYLGLYCINE HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	3 / 3	ASN A  79 ASN A 171 ARG A 224	OCS  A   2 ( 3.7A) OCS  A   2 ( 3.2A) OCS  A   2 ( 3.3A)	0.77A	2rlcA-5hkeA: 42.3	2rlcA-5hkeA: 36.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_A_BEZA1222_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 7	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.59A	2v2gA-5xbqA: 24.4 2v2gB-5xbqA: 24.6	2v2gA-5xbqA: undetectable 2v2gB-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_B_BEZB1220_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 7	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.57A	2v2gA-5xbqA: 24.4 2v2gB-5xbqA: 24.6	2v2gA-5xbqA: undetectable 2v2gB-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_C_BEZC1222_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 7	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.58A	2v2gC-5xbqA: 24.4 2v2gD-5xbqA: 24.5	2v2gC-5xbqA: undetectable 2v2gD-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_D_BEZD1221_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 7	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.60A	2v2gC-5xbqA: 24.4 2v2gD-5xbqA: 24.5	2v2gC-5xbqA: undetectable 2v2gD-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_A_BEZA1222_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	5 / 8	THR A  43 PRO A  44 VAL A  45 ARG A 121 ALA A 140	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A) None	0.50A	2v32A-5xbqA: 24.4 2v32B-5xbqA: 24.5	2v32A-5xbqA: undetectable 2v32B-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_C_BEZC1222_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	5 / 8	PRO A  39 THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.57A	2v32C-5xbqA: 24.4 2v32D-5xbqA: 25.7	2v32C-5xbqA: undetectable 2v32D-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_D_BEZD1221_0 (PEROXIREDOXIN 6)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 8	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.58A	2v32C-5xbqA: 24.4 2v32D-5xbqA: 25.7	2v32C-5xbqA: undetectable 2v32D-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_A_BEZA1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	6 / 9	PRO A  39 THR A  43 PRO A  44 VAL A  45 ARG A 121 ALA A 140	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A) None	0.52A	2v41A-5xbqA: 21.8 2v41B-5xbqA: 24.4	2v41A-5xbqA: undetectable 2v41B-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_B_BEZB1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	6 / 9	PRO A  39 THR A  43 PRO A  44 VAL A  45 ARG A 121 ALA A 140	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A) None	0.54A	2v41A-5xbqA: 24.3 2v41B-5xbqA: 24.4	2v41A-5xbqA: undetectable 2v41B-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_C_BEZC1218_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	5 / 8	PRO A  39 THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.58A	2v41C-5xbqA: 25.9 2v41D-5xbqA: 26.2	2v41C-5xbqA: undetectable 2v41D-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_D_BEZD1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	5 / 8	PRO A  39 THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.60A	2v41C-5xbqA: 25.9 2v41D-5xbqA: 26.2	2v41C-5xbqA: undetectable 2v41D-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_E_BEZE1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 7	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.49A	2v41E-5xbqA: 24.2 2v41F-5xbqA: 24.4	2v41E-5xbqA: undetectable 2v41F-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_F_BEZF1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	4 / 7	THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.58A	2v41E-5xbqA: 24.2 2v41F-5xbqA: 24.4	2v41E-5xbqA: undetectable 2v41F-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_G_BEZG1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	5 / 8	THR A  43 PRO A  44 VAL A  45 ARG A 121 ALA A 140	OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A) None	0.54A	2v41G-5xbqA: 24.5 2v41H-5xbqA: 24.3	2v41G-5xbqA: undetectable 2v41H-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_H_BEZH1222_0 (PEROXIREDOXIN 6.)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	5 / 8	PRO A  39 THR A  43 PRO A  44 VAL A  45 ARG A 121	OCS  A  46 ( 3.3A) OCS  A  46 ( 3.6A) None OCS  A  46 ( 3.0A) OCS  A  46 ( 2.3A)	0.57A	2v41G-5xbqA: 24.5 2v41H-5xbqA: 24.3	2v41G-5xbqA: undetectable 2v41H-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WET_B_TRPB650_0 (TRYPTOPHAN 5-HALOGENASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 10	SER A  91 ILE A   6 HIS A   8 GLN A 171 GLU A  70	OCS  A  88 ( 2.6A) None None OCS  A  88 ( 4.1A) None	1.46A	2wetB-1o1yA: 2.5	2wetB-1o1yA: 18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	6 / 12	GLY A 111 SER A 130 LEU A 136 GLY A 138 GLY A 139 PRO A 142	None OCS  A  86 ( 3.8A) None None None None	0.63A	3axzA-3ky7A: 20.6	3axzA-3ky7A: 44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	6 / 12	PRO A  87 GLY A 111 SER A 130 LEU A 136 GLY A 138 GLY A 139	OCS  A  86 ( 2.5A) None OCS  A  86 ( 3.8A) None None None	0.64A	3axzA-3ky7A: 20.6	3axzA-3ky7A: 44.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DEU_A_SALA301_1 (TRANSCRIPTIONAL REGULATOR SLYA)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	4 / 6	ARG A 142 ILE A 139 VAL A 137 HIS A 133	None OCS  A  87 ( 4.6A) None OCS  A  87 ( 4.0A)	1.04A	3deuA-1lmeA: undetectable	3deuA-1lmeA: 24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DEU_B_SALB302_1 (TRANSCRIPTIONAL REGULATOR SLYA)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	4 / 5	ARG A 142 ILE A 139 VAL A 137 HIS A 133	None OCS  A  87 ( 4.6A) None OCS  A  87 ( 4.0A)	1.11A	3deuB-1lmeA: 0.0	3deuB-1lmeA: 24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DL9_B_V2HB602_0 (CYTOCHROME P450 2R1)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 12	MET A 181 THR A 180 VAL A 134 ALA A 206 ILE A  87	None None None None OCS  A  88 ( 4.0A)	1.12A	3dl9B-1o1yA: 0.0	3dl9B-1o1yA: 19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3DMT_C_CCSC166_0 (GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, GLYCOSOMAL)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	4 / 8	ASN O 388 TYR O 392 ASN O 227 TYR O 386	NAD  O 501 (-3.9A) NAD  O 501 (-2.7A) OCS  O 224 ( 4.8A) OCS  O 224 ( 4.0A)	0.94A	3dmtC-5c7oO: 49.8	3dmtC-5c7oO: 52.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3DMT_C_CCSC166_0 (GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, GLYCOSOMAL)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	8 / 8	SER O 223 THR O 225 ASN O 227 CYH O 228 HIS O 251 TYR O 386 ASN O 388 TYR O 392	OCS  O 224 ( 3.4A) OCS  O 224 ( 4.2A) OCS  O 224 ( 4.8A) None OCS  O 224 ( 3.9A) OCS  O 224 ( 4.0A) NAD  O 501 (-3.9A) NAD  O 501 (-2.7A)	0.24A	3dmtC-5c7oO: 49.8	3dmtC-5c7oO: 52.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMT_C_CCSC166_0 (GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, GLYCOSOMAL)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	4 / 8	ASN A 314 TYR A 318 ASN A 152 TYR A 312	NAD  A 401 (-3.7A) NAD  A 401 (-3.5A) None OCS  A 149 ( 4.1A)	0.94A	3dmtC-5ur0A: 49.7	3dmtC-5ur0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DMT_C_CCSC166_0 (GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, GLYCOSOMAL)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	8 / 8	SER A 148 THR A 150 ASN A 152 CYH A 153 HIS A 176 TYR A 312 ASN A 314 TYR A 318	OCS  A 149 ( 3.5A) OCS  A 149 ( 3.8A) None None OCS  A 149 ( 4.0A) OCS  A 149 ( 4.1A) NAD  A 401 (-3.7A) NAD  A 401 (-3.5A)	0.24A	3dmtC-5ur0A: 49.7	3dmtC-5ur0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DRC_B_MTXB361_1 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.08A	3drcB-3shoA: undetectable	3drcB-3shoA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FSU_A_C2FA995_0 (5,10-METHYLENETETRAH YDROFOLATE REDUCTASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	5 / 12	THR B2328 LEU B2397 SER C3066 ASN C3070 LEU B2313	None None OCS  C3065 ( 4.1A) None None	1.41A	3fsuA-1e6yB: undetectable	3fsuA-1e6yB: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H0A_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	6 / 12	ALA B2205 ALA B2393 LEU B2397 ALA B2396 VAL B2265 ILE B2262	OCS  C3065 ( 3.6A) None None None None None	1.44A	3h0aA-1e6yB: undetectable	3h0aA-1e6yB: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H5G_B_LEIB16_0 (COIL SER L16D-PEN)	2voa	EXODEOXYRIBONUCLEASE III (Archaeoglobus fulgidus)	4 / 5	LYS A 120 GLN A 122 LEU A 124 GLU A 125	OCS  A 167 ( 3.0A) None None None	0.85A	3h5gA-2voaA: undetectable 3h5gB-2voaA: undetectable	3h5gA-2voaA: 9.39 3h5gB-2voaA: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H9U_B_ADNB438_1 (ADENOSYLHOMOCYSTEINA SE)	5vrb	TRANSKETOLASE (Neisseria gonorrhoeae)	5 / 10	ASN A  61 LEU A  59 GLY A  62 HIS A  63 PHE A  87	OCS  A 154 ( 4.3A) None None CA  A 704 ( 4.9A) None	1.26A	3h9uB-5vrbA: 2.6	3h9uB-5vrbA: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_B_EPAB1_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	5 / 12	TYR A 312 ASN A 222 GLY A 209 ALA A 210 GLY A 215	OCS  A 149 ( 4.1A) None None None None	0.90A	3hs6B-5ur0A: undetectable	3hs6B-5ur0A: 11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JAY_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	4o5a	LACI FAMILY TRANSCRIPTION REGULATOR (Bifidobacterium animalis)	5 / 12	SER A 284 MET A 286 ARG A 193 VAL A 194 ASP A 255	GOL  A 403 (-4.7A) None OCS  A 223 ( 4.9A) None None	1.46A	3jayA-4o5aA: undetectable	3jayA-4o5aA: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KPB_C_SAMC1000_0 (UNCHARACTERIZED PROTEIN MJ0100)	5txw	PEPTIDASE (Thermococcus thioreducens)	5 / 12	HIS A 101 THR A 122 VAL A 127 ILE A 107 PRO A 103	OCS  A 100 ( 3.8A) None None None OCS  A 100 ( 4.3A)	1.25A	3kpbC-5txwA: undetectable	3kpbC-5txwA: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KPB_D_SAMD1000_0 (UNCHARACTERIZED PROTEIN MJ0100)	2p8e	PPM1B BETA ISOFORM VARIANT 6 (Homo sapiens)	5 / 10	TRP A 274 THR A 278 ILE A 245 ILE A 290 SER A  27	None None OCS  A 242 ( 4.1A) None None	1.41A	3kpbD-2p8eA: undetectable	3kpbD-2p8eA: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OGQ_A_AB1A200_2 (FIV PROTEASE)	3r0v	ALPHA/BETA HYDROLASE FOLD PROTEIN (Sphaerobacter thermophilus)	5 / 12	LEU A 106 GLY A  84 ALA A  85 ILE A  50 SER A  98	None None None OCS  A  51 ( 3.6A) None	0.99A	3ogqB-3r0vA: undetectable	3ogqB-3r0vA: 14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_C_SAMC6735_0 (16S RRNA METHYLASE)	2ilu	ALDEHYDE DEHYDROGENASE A (Escherichia coli)	6 / 12	GLY A 253 VAL A 284 ASN A 153 ALA A 256 LEU A 250 LEU A 411	None None None SO4  A 480 (-3.8A) OCS  A 249 ( 3.7A) SO4  A 480 (-4.3A)	1.25A	3p2kC-2iluA: 4.3	3p2kC-2iluA: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RF4_A_FUNA201_1 (MACROPHAGE MIGRATION INHIBITORY FACTOR)	3gs9	PROTEIN GP18 (Listeria monocytogenes)	5 / 11	PRO A  89 SER A  37 ILE A  38 VAL A  61 ILE A  91	None None OCS  A  27 ( 4.2A) None None	1.21A	3rf4A-3gs9A: undetectable 3rf4C-3gs9A: undetectable	3rf4A-3gs9A: 15.52 3rf4C-3gs9A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RF4_B_FUNB202_1 (MACROPHAGE MIGRATION INHIBITORY FACTOR)	3gs9	PROTEIN GP18 (Listeria monocytogenes)	5 / 11	ILE A  91 PRO A  89 SER A  37 ILE A  38 VAL A  61	None None None OCS  A  27 ( 4.2A) None	1.21A	3rf4A-3gs9A: undetectable 3rf4B-3gs9A: undetectable	3rf4A-3gs9A: 15.52 3rf4B-3gs9A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RF4_C_FUNC203_1 (MACROPHAGE MIGRATION INHIBITORY FACTOR)	3gs9	PROTEIN GP18 (Listeria monocytogenes)	5 / 11	ILE A  91 PRO A  89 SER A  37 ILE A  38 VAL A  61	None None None OCS  A  27 ( 4.2A) None	1.23A	3rf4B-3gs9A: undetectable 3rf4C-3gs9A: undetectable	3rf4B-3gs9A: 15.52 3rf4C-3gs9A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ROZ_A_NCAA266_0 (APOLIPOPROTEIN A-I-BINDING PROTEIN)	4hpe	PUTATIVE CELL WALL HYDROLASE TN916-LIKE,CTN1-ORF1 7 (Clostridioides difficile)	4 / 6	LEU A 281 ALA A 221 LEU A 245 THR A 246	None None OCS  A 242 ( 4.4A) OCS  A 242 ( 3.4A)	1.12A	3rozA-4hpeA: undetectable	3rozA-4hpeA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_D_SUED1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4oh1	L-IDITOL 2-DEHYDROGENASE ([Clostridium] scindens)	5 / 12	HIS A  73 GLY A  72 GLY A  46 SER A  47 SER A 164	ZN  A 401 (-3.5A) None OCS  A  45 ( 2.4A) OCS  A  45 ( 3.0A) None	1.20A	3sueD-4oh1A: undetectable	3sueD-4oh1A: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_D_SAMD300_0 (PUTATIVE METHYLTRANSFERASE)	5txw	PEPTIDASE (Thermococcus thioreducens)	5 / 12	GLY A 102 GLN A 104 PHE A   5 GLU A  74 ALA A  72	OCS  A 100 ( 4.5A) None None None None	1.30A	3t7sD-5txwA: undetectable	3t7sD-5txwA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TYE_B_YTZB902_1 (DIHYDROPTEROATE SYNTHASE)	2pn0	PROKARYOTIC TRANSCRIPTION ELONGATION FACTOR GREA/GREB (Nitrosomonas europaea)	3 / 3	PHE A  63 LYS A  74 SER A  59	None OCS  A  73 ( 3.5A) None	1.35A	3tyeB-2pn0A: undetectable	3tyeB-2pn0A: 19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_A_08JA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	3zxo	REDOX SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS (Mycobacterium tuberculosis)	4 / 8	VAL A 485 LEU A 456 LEU A 482 ILE A 525	None None None OCS  A 524 ( 4.0A)	0.87A	3u5kA-3zxoA: undetectable	3u5kA-3zxoA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_C_08JC3_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	3zxo	REDOX SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS (Mycobacterium tuberculosis)	4 / 8	VAL A 485 LEU A 456 LEU A 482 ILE A 525	None None None OCS  A 524 ( 4.0A)	0.87A	3u5kC-3zxoA: undetectable	3u5kC-3zxoA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_A_ADNA401_2 (ADENOSINE KINASE, PUTATIVE)	3uk1	TRANSKETOLASE (Burkholderia thailandensis)	4 / 5	LEU A 201 MET A  53 PHE A  80 ASN A  84	None None None OCS  A 177 ( 4.2A)	1.29A	3uq6A-3uk1A: undetectable	3uq6A-3uk1A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQB_A_FK5A114_1 (UBIQUITIN-LIKE PROTEIN SMT3, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	4fdy	SIMILAR TO LIPOPROTEIN, NLP/P60 FAMILY (Staphylococcus aureus)	4 / 8	VAL A 218 ILE A 221 TYR A 254 ILE A 250	None None None OCS  A 246 ( 4.2A)	0.84A	3uqbA-4fdyA: undetectable	3uqbA-4fdyA: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7A_A_RGZA601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	4bwc	PHOSPHOLIPASE B-LIKE 1 (Bos taurus)	5 / 11	TYR B 352 LEU A 118 GLN B 298 ILE A 196 TYR B 288	None None OCS  B 225 ( 4.9A) None None	1.37A	4a7aA-4bwcB: undetectable	4a7aA-4bwcB: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	4fdy	SIMILAR TO LIPOPROTEIN, NLP/P60 FAMILY (Staphylococcus aureus)	4 / 7	TYR A 233 ASP A 245 SER A 247 HIS A 300	None OCS  A 246 ( 4.2A) OCS  A 246 ( 3.5A) OCS  A 246 ( 3.8A)	1.36A	4arcA-4fdyA: undetectable	4arcA-4fdyA: 16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ARC_A_LEUA1001_0 (LEUCINE--TRNA LIGASE)	4hpe	PUTATIVE CELL WALL HYDROLASE TN916-LIKE,CTN1-ORF1 7 (Clostridioides difficile)	4 / 7	TYR A 229 ASP A 241 SER A 243 HIS A 296	OCS  A 242 ( 4.7A) OCS  A 242 ( 4.1A) OCS  A 242 ( 3.6A) OCS  A 242 ( 3.7A)	1.26A	4arcA-4hpeA: undetectable	4arcA-4hpeA: 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D33_B_ACTB860_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	5jmu	PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE ([Eubacterium] rectale)	4 / 5	GLY A 401 ILE A 402 VAL A 494 SER A 395	OCS  A 399 ( 4.2A) OCS  A 399 ( 3.6A) None None	1.19A	4d33B-5jmuA: undetectable	4d33B-5jmuA: 20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DFR_B_MTXB162_1 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.09A	4dfrB-3shoA: undetectable	4dfrB-3shoA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DM8_A_REAA501_1 (RETINOIC ACID RECEPTOR BETA)	3gs9	PROTEIN GP18 (Listeria monocytogenes)	5 / 11	PHE A  26 LEU A  18 ILE A   6 PHE A 310 ILE A  86	OCS  A  27 ( 4.1A) None None None None	1.14A	4dm8A-3gs9A: undetectable	4dm8A-3gs9A: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_A_LNLA701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	5 / 12	TYR A 312 ASN A 222 GLY A 209 ALA A 210 GLY A 215	OCS  A 149 ( 4.1A) None None None None	0.82A	4e1gA-5ur0A: undetectable	4e1gA-5ur0A: 11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F84_A_SAMA501_0 (GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERAS E)	3rh0	ARSENATE REDUCTASE (Corynebacterium glutamicum)	5 / 12	GLY A  13 GLY A  10 LEU A  80 MET A  17 VAL A 115	OCS  A   8 ( 4.5A) OCS  A   8 ( 4.1A) None None None	1.12A	4f84A-3rh0A: 2.4	4f84A-3rh0A: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IJI_F_BEZF501_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	4 / 8	ASN A 358 ALA A 156 SER A 155 ARG A 392	None None OCS  A 784 ( 3.2A) None	1.18A	4ijiF-3o5aA: undetectable	4ijiF-3o5aA: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLA_A_CHDA502_0 (FERROCHELATASE, MITOCHONDRIAL)	2f1k	PREPHENATE DEHYDROGENASE (Synechocystis sp. PCC 6803)	4 / 8	LEU A 158 LEU A 155 LEU A 151 VAL A   5	None None OCS  A 150 ( 4.6A) None	0.89A	4klaA-2f1kA: 2.1	4klaA-2f1kA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KRH_B_SAMB900_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2)	2ilu	ALDEHYDE DEHYDROGENASE A (Escherichia coli)	5 / 12	GLY A 229 GLY A 253 LEU A 250 ALA A 233 ILE A 149	NDP  A 482 (-3.5A) None OCS  A 249 ( 3.7A) NDP  A 482 (-3.2A) NDP  A 482 (-4.1A)	1.12A	4krhB-2iluA: 4.8	4krhB-2iluA: 22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_B_MTXB301_1 (GAMMA-GLUTAMYL HYDROLASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 11	GLY A  53 GLY A  54 LEU A  89 HIS A 138 HIS A 173	OCS  A  88 ( 3.5A) OCS  A  88 (-4.2A) OCS  A  88 ( 4.7A) None OCS  A  88 ( 3.9A)	0.72A	4l8fB-1o1yA: 17.3	4l8fB-1o1yA: 22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_D_MTXD301_1 (GAMMA-GLUTAMYL HYDROLASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 11	GLY A  53 GLY A  54 LEU A  89 HIS A 138 HIS A 173	OCS  A  88 ( 3.5A) OCS  A  88 (-4.2A) OCS  A  88 ( 4.7A) None OCS  A  88 ( 3.9A)	0.73A	4l8fD-1o1yA: 17.4	4l8fD-1o1yA: 22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNW_A_T3A502_1 (THYROID HORMONE RECEPTOR ALPHA)	4fdy	SIMILAR TO LIPOPROTEIN, NLP/P60 FAMILY (Staphylococcus aureus)	4 / 8	SER A 247 GLN A 268 VAL A 298 THR A 296	OCS  A 246 ( 3.5A) None None None	1.12A	4lnwA-4fdyA: undetectable	4lnwA-4fdyA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNX_A_T44A501_1 (THYROID HORMONE RECEPTOR ALPHA)	4fdy	SIMILAR TO LIPOPROTEIN, NLP/P60 FAMILY (Staphylococcus aureus)	4 / 6	SER A 247 GLN A 268 VAL A 298 THR A 296	OCS  A 246 ( 3.5A) None None None	1.25A	4lnxA-4fdyA: undetectable	4lnxA-4fdyA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_E_TMQE202_1 (DIHYDROFOLATE REDUCTASE)	4fdy	SIMILAR TO LIPOPROTEIN, NLP/P60 FAMILY (Staphylococcus aureus)	5 / 12	ILE A 221 ASP A 245 ARG A 263 LEU A 285 ILE A 303	None OCS  A 246 ( 4.2A) None None None	1.08A	4m2xE-4fdyA: undetectable	4m2xE-4fdyA: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA3_L_ACTL301_0 (C2095 HEAVY CHAIN C2095 LIGHT CHAIN)	3ze7	PERIPLASMIC [NIFESE] HYDROGENASE, LARGE SUBUNIT, SELENOCYSTEINE-CONTA INING (Desulfovibrio vulgaris)	3 / 3	PRO B  79 ASN B 113 HIS B 173	OCS  B  75 ( 3.1A) H2S  B 503 (-4.1A) None	1.00A	4ma3H-3ze7B: undetectable 4ma3L-3ze7B: undetectable	4ma3H-3ze7B: 18.59 4ma3L-3ze7B: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMC_A_29JA603_1 (TRANSPORTER)	2p8e	PPM1B BETA ISOFORM VARIANT 6 (Homo sapiens)	5 / 10	VAL A  58 TYR A  59 GLY A 150 GLY A 136 ASP A  38	None None None None OCS  A 242 ( 2.7A)	1.43A	4mmcA-2p8eA: undetectable	4mmcA-2p8eA: 19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MS4_A_2C0A501_1 (GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1)	3fgt	PUTATIVE PHOSPHOLIPASE B-LIKE 2 40 KDA FORM (Mus musculus)	4 / 8	SER B 305 HIS B 266 TYR B 307 GLU B 328	None OCS  B 249 ( 4.3A) None NA  B 606 (-2.7A)	1.27A	4ms4A-3fgtB: undetectable	4ms4A-3fgtB: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MS4_A_2C0A501_1 (GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1)	3fgt	PUTATIVE PHOSPHOLIPASE B-LIKE 2 40 KDA FORM (Mus musculus)	4 / 8	SER B 305 HIS B 266 TYR B 307 ILE B 536	None OCS  B 249 ( 4.3A) None None	1.35A	4ms4A-3fgtB: undetectable	4ms4A-3fgtB: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_B_ADNB401_1 (ADENOSINE KINASE)	4oh1	L-IDITOL 2-DEHYDROGENASE ([Clostridium] scindens)	5 / 12	LEU A 162 GLY A 182 GLY A 183 ALA A 161 GLY A  46	None None None None OCS  A  45 ( 2.4A)	0.96A	4n09B-4oh1A: 5.6	4n09B-4oh1A: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_1 (ADENOSINE KINASE)	4oh1	L-IDITOL 2-DEHYDROGENASE ([Clostridium] scindens)	6 / 12	LEU A 162 GLY A 182 GLY A 183 ALA A 161 LEU A 191 GLY A  46	None None None None None OCS  A  45 ( 2.4A)	1.19A	4n09C-4oh1A: 4.9	4n09C-4oh1A: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_C_ADNC401_2 (ADENOSINE KINASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	4 / 5	ASN A  79 LEU A 139 LEU A 136 ASN A 127	OCS  A   2 ( 3.7A) None None None	1.26A	4n09C-5hkeA: undetectable	4n09C-5hkeA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N09_D_ADND401_1 (ADENOSINE KINASE)	4oh1	L-IDITOL 2-DEHYDROGENASE ([Clostridium] scindens)	5 / 12	LEU A 162 GLY A 182 GLY A 183 ALA A 161 GLY A  46	None None None None OCS  A  45 ( 2.4A)	0.97A	4n09D-4oh1A: 5.6	4n09D-4oh1A: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NX6_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.07A	4nx6A-3shoA: 2.4	4nx6A-3shoA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NX7_A_FOLA202_0 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.10A	4nx7A-3shoA: 2.4	4nx7A-3shoA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_A_SAMA602_1 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	3o5a	PERIPLASMIC NITRATE REDUCTASE (Cupriavidus necator)	3 / 3	ASP A 146 ASN A 143 SER A 787	None None OCS  A 784 ( 3.2A)	0.76A	4obwA-3o5aA: 3.6	4obwA-3o5aA: 15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P3Q_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	4 / 5	ASP A  21 LEU A  20 ARG A  16 THR A 264	None None OCS  A   2 ( 4.1A) None	1.39A	4p3qA-5hkeA: undetectable	4p3qA-5hkeA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PFJ_B_ADNB502_2 (ADENOSYLHOMOCYSTEINA SE)	3fgt	PUTATIVE PHOSPHOLIPASE B-LIKE 2 40 KDA FORM (Mus musculus)	4 / 6	GLN B 408 THR B 268 HIS B 266 ASN B 354	None OCS  B 249 ( 4.0A) OCS  B 249 ( 4.3A) None	1.37A	4pfjB-3fgtB: undetectable	4pfjB-3fgtB: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PST_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	3sho	TRANSCRIPTIONAL REGULATOR, RPIR FAMILY (Sphaerobacter thermophilus)	5 / 12	ALA A 126 LEU A 231 ILE A 187 LEU A 152 ILE A 131	None None None None OCS  A 132 ( 3.7A)	1.05A	4pstA-3shoA: undetectable	4pstA-3shoA: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PTJ_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	5yhh	UNCHARACTERIZED CONSERVED PROTEIN YIIM (Geobacillus stearothermophil us)	3 / 3	ASP A  26 LYS A 120 LEU A 131	None OCS  A 119 ( 3.1A) None	1.08A	4ptjA-5yhhA: undetectable	4ptjA-5yhhA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	1kcz	BETA-METHYLASPARTASE (Clostridium tetanomorphum)	5 / 12	GLY A 394 GLY A 388 GLY A  14 ASN A 362 ALA A 385	None OCS  A 361 ( 3.5A) OCS  A 361 ( 3.4A) None None	1.01A	4uciA-1kczA: undetectable	4uciA-1kczA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	1kcz	BETA-METHYLASPARTASE (Clostridium tetanomorphum)	5 / 12	GLY A 394 GLY A 388 GLY A  14 ASN A 362 ALA A 385	None OCS  A 361 ( 3.5A) OCS  A 361 ( 3.4A) None None	1.01A	4uciB-1kczA: undetectable	4uciB-1kczA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_B_SAMB1548_0 (CYSTATHIONINE BETA-SYNTHASE)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	5 / 11	SER A 148 LEU A 154 PRO A 156 VAL A 129 THR A 127	OCS  A 149 ( 3.5A) None None None PGE  A 402 (-4.7A)	1.23A	4uuuB-5ur0A: undetectable	4uuuB-5ur0A: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	6 / 12	GLY A 111 SER A 130 LEU A 136 GLY A 138 GLY A 139 PRO A 142	None OCS  A  86 ( 3.8A) None None None None	0.67A	4yvgA-3ky7A: 19.7	4yvgA-3ky7A: 44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	5 / 12	PRO A  87 GLY A 111 GLU A 114 GLY A 138 GLY A 139	OCS  A  86 ( 2.5A) None None None None	1.06A	4yvgA-3ky7A: 19.7	4yvgA-3ky7A: 44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	6 / 12	PRO A  87 GLY A 111 SER A 130 LEU A 136 GLY A 138 GLY A 139	OCS  A  86 ( 2.5A) None OCS  A  86 ( 3.8A) None None None	0.63A	4yvgA-3ky7A: 19.7	4yvgA-3ky7A: 44.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C6P_A_4YHA601_1 (PROTEIN C)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 6	ALA B2210 SER B2209 SER C3066 ASP B2009	None None OCS  C3065 ( 4.1A) None	1.09A	5c6pA-1e6yB: 0.0	5c6pA-1e6yB: 23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DXB_B_ESTB601_1 (ESTROGEN RECEPTOR)	4uup	MALATE DEHYDROGENASE (synthetic construct)	5 / 11	ALA A 247 LEU A  29 ARG A 253 ILE A   9 GLY A  17	OCS  A 250 (-4.4A) None OCS  A 250 (-3.4A) None None	1.12A	5dxbB-4uupA: undetectable	5dxbB-4uupA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_2_BEZ2801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 BEZ-LEU-LEU)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	4 / 4	LEU A 138 ARG A  99 ILE A 139 ILE A  97	OCS  A  87 ( 4.8A) None OCS  A  87 ( 4.6A) None	1.33A	5dzk2-1lmeA: undetectable 5dzkM-1lmeA: undetectable 5dzkN-1lmeA: undetectable	5dzk2-1lmeA: 1.23 5dzkM-1lmeA: 21.60 5dzkN-1lmeA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_V_BEZV801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 BEZ-LEU-LEU)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	4 / 4	ILE A 139 ILE A  97 ARG A  99 LEU A 138	OCS  A  87 ( 4.6A) None None OCS  A  87 ( 4.8A)	1.34A	5dzkh-1lmeA: undetectable 5dzkn-1lmeA: 0.0 5dzkv-1lmeA: undetectable	5dzkh-1lmeA: 21.60 5dzkn-1lmeA: 21.60 5dzkv-1lmeA: 1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_A_5OGA804_1 (HDAC6 PROTEIN)	2voa	EXODEOXYRIBONUCLEASE III (Archaeoglobus fulgidus)	5 / 12	HIS A 165 ASP A 218 HIS A 248 ASP A 146 GLY A 217	OCS  A 167 ( 4.1A) None None None None	1.19A	5eenA-2voaA: undetectable	5eenA-2voaA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERS_A_ACTA803_0 (GEPHYRIN)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	3 / 3	THR O 226 ALA O 222 ASN O 227	None None OCS  O 224 ( 4.8A)	0.55A	5ersA-5c7oO: 2.3	5ersA-5c7oO: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EWU_B_BEZB1401_0 (MAGNESIUM-CHELATASE SUBUNIT CHLH, CHLOROPLASTIC)	3rh0	ARSENATE REDUCTASE (Corynebacterium glutamicum)	4 / 6	GLY A  36 THR A  37 SER A  15 VAL A   7	OCS  A   8 ( 3.1A) OCS  A   8 ( 3.6A) OCS  A   8 ( 2.6A) OCS  A   8 ( 2.9A)	1.01A	5ewuB-3rh0A: undetectable	5ewuB-3rh0A: 14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_A_X2NA590_2 (CYP51 VARIANT1)	4cit	VANADIUM-DEPENDENT HALOPEROXIDASE (Zobellia galactanivorans)	3 / 3	PRO A 262 ILE A 254 SER A  50	OCS  A 260 ( 4.9A) None None	0.80A	5fsaA-4citA: undetectable	5fsaA-4citA: 22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWX_A_SAMA301_0 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	3uk1	TRANSKETOLASE (Burkholderia thailandensis)	5 / 12	ALA A 186 GLY A 438 GLY A 181 GLY A 145 LEU A 173	None None None None OCS  A 177 ( 4.1A)	0.86A	5gwxA-3uk1A: 2.9	5gwxA-3uk1A: 17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_A_BEZA301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 10	GLY A  54 TYR A  55 LEU A  89 LEU A  67 GLU A  60	OCS  A  88 (-4.2A) None OCS  A  88 ( 4.7A) None None	1.31A	5hwkA-1o1yA: undetectable	5hwkA-1o1yA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_A_BEZA301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 10	TYR A  55 LEU A  89 LEU A  67 GLU A  60 TYR A  64	None OCS  A  88 ( 4.7A) None None None	1.33A	5hwkA-1o1yA: undetectable	5hwkA-1o1yA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_B_BEZB301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 10	GLY A  54 TYR A  55 LEU A  89 LEU A  67 GLU A  60	OCS  A  88 (-4.2A) None OCS  A  88 ( 4.7A) None None	1.31A	5hwkB-1o1yA: 0.0	5hwkB-1o1yA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_B_BEZB301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	5 / 10	TYR A  55 LEU A  89 LEU A  67 GLU A  60 TYR A  64	None OCS  A  88 ( 4.7A) None None None	1.33A	5hwkB-1o1yA: 0.0	5hwkB-1o1yA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L8D_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	1kcz	BETA-METHYLASPARTASE (Clostridium tetanomorphum)	3 / 3	THR A 360 PRO A 333 ASP A 334	OCS  A 361 ( 3.3A) None None	0.94A	5l8dB-1kczA: 0.0	5l8dB-1kczA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_H_6V8H305_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	3gzs	UNCHARACTERIZED SUSD SUPERFAMILY PROTEIN (Bacteroides fragilis)	5 / 11	ALA A 403 ALA A 387 GLY A 388 ASP A 314 LEU A 309	None OCS  A 364 ( 3.6A) OCS  A 364 ( 3.6A) None None	1.13A	5lf7H-3gzsA: undetectable 5lf7I-3gzsA: undetectable	5lf7H-3gzsA: 19.38 5lf7I-3gzsA: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MWU_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	1kcz	BETA-METHYLASPARTASE (Clostridium tetanomorphum)	3 / 3	THR A 360 PRO A 333 ASP A 334	OCS  A 361 ( 3.3A) None None	0.94A	5mwuB-1kczA: 0.0	5mwuB-1kczA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0X_B_SAMB501_1 (PEPTIDE N-METHYLTRANSFERASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	3 / 3	SER A 231 ALA A 228 THR A   3	None None OCS  A   2 ( 3.8A)	0.73A	5n0xB-5hkeA: undetectable	5n0xB-5hkeA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_A_CUA601_0 (THIOCYANATE DEHYDROGENASE)	5xbq	PEROXIREDOXIN (Pyrococcus horikoshii)	3 / 3	HIS A  38 ASP A  41 HIS A  78	OCS  A  46 ( 4.6A) None None	0.77A	5oexA-5xbqA: undetectable	5oexA-5xbqA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T7B_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	5c7o	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE, TESTIS-SPECIFIC (Homo sapiens)	4 / 6	PHE O 305 VAL O 250 ALA O 304 THR O 225	None None None OCS  O 224 ( 4.2A)	1.01A	5t7bA-5c7oO: 2.8	5t7bA-5c7oO: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T7B_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	5ur0	GLYCERALDEHYDE-3-PHO SPHATE DEHYDROGENASE (Naegleria gruberi)	4 / 6	PHE A 230 VAL A 175 ALA A 229 THR A 150	None None None OCS  A 149 ( 3.8A)	1.02A	5t7bA-5ur0A: 3.5	5t7bA-5ur0A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TT3_A_EZLA303_1 (ALPHA-CARBONIC ANHYDRASE)	3r0v	ALPHA/BETA HYDROLASE FOLD PROTEIN (Sphaerobacter thermophilus)	5 / 10	VAL A  49 VAL A  23 LEU A  39 ALA A 250 PRO A 246	OCS  A  51 ( 4.4A) None None None None	1.30A	5tt3A-3r0vA: undetectable	5tt3A-3r0vA: 23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TT3_C_EZLC303_1 (ALPHA-CARBONIC ANHYDRASE)	3r0v	ALPHA/BETA HYDROLASE FOLD PROTEIN (Sphaerobacter thermophilus)	5 / 10	VAL A  49 VAL A  23 LEU A  39 ALA A 250 PRO A 246	OCS  A  51 ( 4.4A) None None None None	1.33A	5tt3C-3r0vA: undetectable	5tt3C-3r0vA: 23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA310_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	3 / 3	GLU A 130 HIS A 129 ARG A 125	None OCS  A  87 ( 3.9A) None	0.97A	5uunA-1lmeA: 0.0	5uunA-1lmeA: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA310_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	1v3y	PEPTIDE DEFORMYLASE (Thermus thermophilus)	3 / 3	GLU A 146 HIS A 145 ARG A 141	None OCS  A 102 ( 3.8A) None	0.95A	5uunA-1v3yA: undetectable	5uunA-1v3yA: 21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_A_SAMA401_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	6 / 12	PRO A  87 GLY A 111 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) None None None None None	0.66A	5wyqA-3ky7A: 20.2	5wyqA-3ky7A: 39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_A_SAMA401_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	7 / 12	PRO A  87 SER A 130 VAL A 135 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) OCS  A  86 ( 3.8A) None None None None None	0.72A	5wyqA-3ky7A: 20.2	5wyqA-3ky7A: 39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_B_SAMB301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	8 / 12	PRO A  87 GLY A 111 SER A 130 TYR A 134 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) None OCS  A  86 ( 3.8A) None None None None None	0.73A	5wyqB-3ky7A: 20.8	5wyqB-3ky7A: 39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_B_SAMB301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	6 / 12	PRO A  87 SER A 130 TYR A 134 LEU A 136 GLY A 138 PRO A 142	OCS  A  86 ( 2.5A) OCS  A  86 ( 3.8A) None None None None	1.22A	5wyqB-3ky7A: 20.8	5wyqB-3ky7A: 39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_B_SAMB301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	5 / 12	TYR A 116 PRO A  87 GLY A 111 ILE A 129 GLY A 139	OCS  A  86 ( 4.6A) OCS  A  86 ( 2.5A) None None None	0.98A	5wyqB-3ky7A: 20.8	5wyqB-3ky7A: 39.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X23_A_LSNA502_1 (CYTOCHROME P450 2C9)	3pnx	PUTATIVE SULFURTRANSFERASE DSRE (Syntrophomonas wolfei)	5 / 12	VAL A 124 MET A 127 GLY A  43 LEU A  22 LEU A 107	OCS  A 120 ( 3.8A) None None None None	1.47A	5x23A-3pnxA: undetectable	5x23A-3pnxA: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1431_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	3kom	TRANSKETOLASE (Francisella tularensis)	4 / 7	ASP A 185 ASP A 157 GLY A 158 ASN A  66	None None OCS  A 159 ( 2.4A) None	1.05A	5x7pA-3komA: undetectable	5x7pA-3komA: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1431_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	3uk1	TRANSKETOLASE (Burkholderia thailandensis)	4 / 7	ASP A 203 ASP A 175 GLY A 176 ASN A  84	None None OCS  A 177 ( 2.4A) OCS  A 177 ( 4.2A)	1.04A	5x7pA-3uk1A: undetectable	5x7pA-3uk1A: 20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_B_CHDB401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	7 / 10	LEU A  18 LEU A  63 ASN A  79 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None OCS  A   2 ( 3.7A) None None None None	1.39A	5y7pB-5hkeA: 52.3	5y7pB-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_B_CHDB401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	8 / 10	LEU A  18 TYR A  24 ILE A  56 LEU A  63 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None None None None None None None	1.43A	5y7pB-5hkeA: 52.3	5y7pB-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_C_CHDC401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	6 / 8	LEU A  18 ILE A  56 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None None None None None	1.26A	5y7pC-5hkeA: 52.3	5y7pC-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_C_CHDC401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	7 / 8	LEU A  20 ILE A  56 ASN A  79 PHE A 100 LEU A 136 ALA A 137 LEU A 139	None None OCS  A   2 ( 3.7A) None None None None	0.38A	5y7pC-5hkeA: 52.3	5y7pC-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_C_CHDC401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	4 / 8	LEU A  20 TYR A  24 ASN A  79 ALA A 137	None None OCS  A   2 ( 3.7A) None	0.82A	5y7pC-5hkeA: 52.3	5y7pC-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_D_CHDD401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	6 / 10	LEU A  18 ASN A  79 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) OCS  A   2 ( 3.7A) None None None None	1.23A	5y7pD-5hkeA: 52.5	5y7pD-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_D_CHDD401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	8 / 10	LEU A  18 TYR A  24 ILE A  56 LEU A  63 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None None None None None None None	1.46A	5y7pD-5hkeA: 52.5	5y7pD-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_E_CHDE401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	7 / 8	ILE A  56 ASN A  79 PHE A 100 LEU A 134 LEU A 136 ALA A 137 LEU A 139	None OCS  A   2 ( 3.7A) None None None None None	0.37A	5y7pE-5hkeA: 52.4	5y7pE-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_G_CHDG401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	7 / 10	ASN A  79 PHE A 100 LEU A 134 LEU A 136 ALA A 137 LEU A 139 GLU A 270	OCS  A   2 ( 3.7A) None None None None None None	0.76A	5y7pG-5hkeA: 52.5	5y7pG-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_G_CHDG401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	7 / 10	LEU A  18 ASN A  79 PHE A 100 LEU A 134 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) OCS  A   2 ( 3.7A) None None None None None	1.35A	5y7pG-5hkeA: 52.5	5y7pG-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_G_CHDG401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	8 / 10	LEU A  18 TYR A  24 ILE A  56 PHE A 100 LEU A 134 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None None None None None None None	1.37A	5y7pG-5hkeA: 52.5	5y7pG-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_H_CHDH401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	7 / 10	LEU A  18 LEU A  63 ASN A  79 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None OCS  A   2 ( 3.7A) None None None None	1.37A	5y7pH-5hkeA: 52.2	5y7pH-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y7P_H_CHDH401_0 (BILE SALT HYDROLASE)	5hke	BILE SALT HYDROLASE (Lactobacillus salivarius)	8 / 10	LEU A  18 TYR A  24 ILE A  56 LEU A  63 PHE A 100 LEU A 136 ALA A 137 LEU A 139	OCS  A   2 ( 3.9A) None None None None None None None	1.44A	5y7pH-5hkeA: 52.2	5y7pH-5hkeA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	7 / 12	PRO A  87 GLY A 111 SER A 130 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) None OCS  A  86 ( 3.8A) None None None None	0.74A	5zhmB-3ky7A: 10.9	5zhmB-3ky7A: 45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ZHM_B_SAMB301_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	3ky7	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Staphylococcus aureus)	7 / 12	PRO A  87 SER A 130 VAL A 135 LEU A 136 GLY A 138 GLY A 139 PRO A 142	OCS  A  86 ( 2.5A) OCS  A  86 ( 3.8A) None None None None None	0.67A	5zhmB-3ky7A: 10.9	5zhmB-3ky7A: 45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	1lme	PEPTIDE DEFORMYLASE (Thermotoga maritima)	3 / 3	HIS A 133 HIS A 129 ARG A  99	OCS  A  87 ( 4.0A) OCS  A  87 ( 3.9A) None	1.13A	6b58A-1lmeA: undetectable	6b58A-1lmeA: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_C_SUEC1203_1 (NS3 PROTEASE)	1v3y	PEPTIDE DEFORMYLASE (Thermus thermophilus)	5 / 9	VAL A 113 GLY A  98 LEU A 105 ARG A 158 ASP A 148	None None OCS  A 102 ( 4.4A) None None	1.45A	6c2mC-1v3yA: undetectable	6c2mC-1v3yA: 17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_C_AQ4C602_1 (CYTOCHROME P450 1A1)	3rh0	ARSENATE REDUCTASE (Corynebacterium glutamicum)	3 / 3	SER A  34 SER A  15 ALA A  40	None OCS  A   8 ( 2.6A) None	0.66A	6dwnC-3rh0A: undetectable	6dwnC-3rh0A: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E5Z_A_CCSA106_0 (PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1)	5txw	PEPTIDASE (Thermococcus thioreducens)	5 / 10	GLU A  15 GLY A  69 GLY A  70 ILE A  99 PRO A 103	OCS  A 100 ( 2.4A) OCS  A 100 ( 3.0A) OCS  A 100 ( 3.7A) OCS  A 100 ( 3.7A) OCS  A 100 ( 4.3A)	0.41A	6e5zA-5txwA: 26.3	6e5zA-5txwA: 29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_A_ADNA502_0 (ADENOSYLHOMOCYSTEINA SE)	5vrb	TRANSKETOLASE (Neisseria gonorrhoeae)	5 / 12	ASN A  61 LEU A  59 GLY A  62 HIS A  63 PHE A  87	OCS  A 154 ( 4.3A) None None CA  A 704 ( 4.9A) None	1.26A	6exiA-5vrbA: undetectable	6exiA-5vrbA: 9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_D_ADND502_0 (ADENOSYLHOMOCYSTEINA SE)	5vrb	TRANSKETOLASE (Neisseria gonorrhoeae)	5 / 12	ASN A  61 LEU A  59 GLY A  62 HIS A  63 PHE A  87	OCS  A 154 ( 4.3A) None None CA  A 704 ( 4.9A) None	1.29A	6exiD-5vrbA: undetectable	6exiD-5vrbA: 9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G31_G_ZOLG401_0 (GERANYLGERANYL PYROPHOSPHATE SYNTHASE)	1o1y	CONSERVED HYPOTHETICAL PROTEIN TM1158 (Thermotoga maritima)	4 / 7	ASP A 140 GLN A  92 LYS A  89 TYR A  55	SO4  A 402 (-3.3A) SO4  A 402 ( 3.9A) OCS  A  88 ( 2.8A) None	1.44A	6g31G-1o1yA: undetectable	6g31G-1o1yA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6J20_A_GBQA1201_1 (SUBSTANCE-P RECEPTOR,ENDOLYSIN)	4rpa	PROBABLE MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE (Staphylococcus aureus)	4 / 7	ILE A  91 GLU A  78 HIS A  76 VAL A  94	None None None OCS  A 110 ( 4.6A)	1.09A	6j20A-4rpaA: undetectable	6j20A-4rpaA: 19.82