SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OBZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 TYR A 144
ARG A 146
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.33A 2a1hA-3dtgA:
44.4
2a1hB-3dtgA:
44.3		 2a1hA-3dtgA:
37.08
2a1hB-3dtgA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 TYR A 144
ARG A 146
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.26A 2a1hA-3dtgA:
44.4
2a1hB-3dtgA:
44.3		 2a1hA-3dtgA:
37.08
2a1hB-3dtgA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		7 / 10 TYR A 144
ARG A 146
TYR A 176
MET A 244
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
OBZ  A 371 (-3.4A)
None
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.49A 2coiA-3dtgA:
45.0
2coiB-3dtgA:
45.1		 2coiA-3dtgA:
37.53
2coiB-3dtgA:
37.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		7 / 10 TYR A 144
ARG A 146
TYR A 176
MET A 244
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
OBZ  A 371 (-3.4A)
None
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.49A 2coiA-3dtgA:
45.0
2coiB-3dtgA:
45.1		 2coiA-3dtgA:
37.53
2coiB-3dtgA:
37.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		8 / 11 PHE A  77
TYR A 144
ARG A 146
TYR A 176
MET A 244
GLY A 313
THR A 314
ALA A 315
 OBZ  A 371 (-4.6A)
None
OBZ  A 371 (-4.2A)
OBZ  A 371 (-3.4A)
None
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.30A 2cojA-3dtgA:
45.3
2cojB-3dtgA:
45.4		 2cojA-3dtgA:
37.53
2cojB-3dtgA:
37.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		6 / 9 TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
None
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.29A 2cojA-3dtgA:
45.3
2cojB-3dtgA:
45.4		 2cojA-3dtgA:
37.53
2cojB-3dtgA:
37.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		6 / 8 TYR A 144
ARG A 146
GLY A 243
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
PLP  A 369 ( 3.8A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.30A 2ej3A-3dtgA:
33.0		 2ej3A-3dtgA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 TYR A 144
ARG A 146
THR A 314
ALA A 315
ALA A 316
 None
OBZ  A 371 (-4.2A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
None
 0.51A 2ej3A-3dtgA:
33.0		 2ej3A-3dtgA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		7 / 10 PHE A  77
TYR A 144
ARG A 146
GLY A 243
GLY A 313
THR A 314
ALA A 315
 OBZ  A 371 (-4.6A)
None
OBZ  A 371 (-4.2A)
PLP  A 369 ( 3.8A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.35A 2ej3B-3dtgA:
33.2		 2ej3B-3dtgA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		8 / 10 PHE A  77
TYR A 144
ARG A 146
TYR A 209
GLY A 313
THR A 314
ALA A 315
ALA A 316
 OBZ  A 371 (-4.6A)
None
OBZ  A 371 (-4.2A)
GOL  A 370 (-3.4A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
None
 0.64A 2ej3B-3dtgA:
33.2		 2ej3B-3dtgA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		6 / 8 TYR A 144
ARG A 146
GLY A 243
GLY A 313
THR A 314
ALA A 315
 None
OBZ  A 371 (-4.2A)
PLP  A 369 ( 3.8A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
 0.33A 2ej3C-3dtgA:
32.7		 2ej3C-3dtgA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		6 / 8 TYR A 144
ARG A 146
GLY A 313
THR A 314
ALA A 315
ALA A 316
 None
OBZ  A 371 (-4.2A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
None
 0.54A 2ej3C-3dtgA:
32.7		 2ej3C-3dtgA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 146
GLU A  78
PHE A 119
 OBZ  A 371 (-4.2A)
None
None
 0.85A 4kszA-3dtgA:
undetectable		 4kszA-3dtgA:
20.50