SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OBN'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus
musculus)
3 / 3 SER H  76
HIS H  35
ASP H  58
None
OBN  H   1 (-4.1A)
None
0.69A 2wa2B-1ibgH:
undetectable
2wa2B-1ibgH:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 10 GLU A 312
PHE A 316
GLY A 319
VAL A 322
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 (-3.7A)
0.74A 3a3yA-3n23A:
55.3
3a3yA-3n23A:
85.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 10 GLU A 312
PHE A 316
GLY A 319
VAL A 322
ALA A 323
PHE A 786
LEU A 793
THR A 797
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
0.48A 3a3yA-3n23A:
55.3
3a3yA-3n23A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
3 / 3 TYR A 974
MET A 973
ILE A 800
None
None
OBN  A   1 ( 4.7A)
0.79A 4c8bB-3n23A:
undetectable
4c8bB-3n23A:
15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
5 / 12 GLN A 111
GLU A 312
PHE A 786
LEU A 793
ARG A 880
OBN  A   1 (-3.8A)
None
None
None
OBN  A   1 (-3.7A)
0.99A 4hytA-3n23A:
58.3
4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
1.01A 4hytA-3n23A:
58.3
4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 786
LEU A 793
THR A 797
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
0.86A 4hytA-3n23A:
58.3
4hytA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
6 / 12 GLN A 111
GLU A 312
PHE A 783
PHE A 786
LEU A 793
ARG A 880
OBN  A   1 (-3.8A)
None
OBN  A   1 (-3.5A)
None
None
OBN  A   1 (-3.7A)
1.10A 4hytC-3n23A:
45.5
4hytC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
1.02A 4hytC-3n23A:
45.5
4hytC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
PHE A 786
LEU A 793
THR A 797
ILE A 800
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 ( 4.7A)
OBN  A   1 (-3.7A)
0.86A 4hytC-3n23A:
45.5
4hytC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
8 / 12 ASP A 121
LEU A 125
PHE A 316
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
OBN  A   1 (-3.4A)
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
0.92A 4retA-3n23A:
58.1
4retA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 LEU A 125
GLU A 312
PHE A 316
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
ARG A 880
None
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
OBN  A   1 (-3.7A)
0.94A 4retA-3n23A:
58.1
4retA-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
7 / 12 ASP A 121
LEU A 125
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
OBN  A   1 (-3.4A)
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
0.96A 4retC-3n23A:
52.4
4retC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
8 / 12 LEU A 125
GLU A 312
GLY A 319
ALA A 323
GLU A 327
PHE A 783
LEU A 793
ARG A 880
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
OBN  A   1 (-3.5A)
None
OBN  A   1 (-3.7A)
0.97A 4retC-3n23A:
52.4
4retC-3n23A:
97.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
9 / 12 ASP A 121
LEU A 125
GLU A 312
GLY A 319
ALA A 323
GLU A 327
PHE A 786
ILE A 800
ASP A 884
OBN  A   1 (-3.4A)
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 ( 4.8A)
0.82A 4xe5A-3n23A:
47.7
4xe5A-3n23A:
95.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 PRO A 118
ILE A 315
THR A 797
ARG A 880
OBN  A   1 (-3.6A)
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
1.05A 4xe5A-3n23A:
47.7
4xe5A-3n23A:
95.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 6 PRO A 118
VAL A 322
PHE A 783
ARG A 880
OBN  A   1 (-3.6A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
OBN  A   1 (-3.7A)
1.18A 4xe5A-3n23A:
47.7
4xe5A-3n23A:
95.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1

(Sus
scrofa)
6 / 12 PHE B  50
ILE B  54
GLY A 857
THR A 918
HIS A 912
THR A 797
None
None
None
None
None
OBN  A   1 (-2.8A)
1.43A 5jlcA-3n23B:
undetectable
5jlcA-3n23B:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus
scrofa)
4 / 8 TYR A 847
ILE A 777
ALA A 323
VAL A 322
None
None
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
1.00A 6hu9a-3n23A:
1.9
6hu9e-3n23A:
0.3
6hu9a-3n23A:
19.48
6hu9e-3n23A:
8.03