SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OAN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		5 / 11 VAL D 161
CYH D 163
TYR D 121
TRP D 373
TYR D  88
 None
None
None
OAN  D1627 (-3.7A)
None
 1.50A 1jkhA-5a6bD:
undetectable
1jkhB-5a6bD:
1.4		 1jkhA-5a6bD:
22.66
1jkhB-5a6bD:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 5 HIS A 196
ASP A 254
HIS A 258
ASP A 321
 None
None
OAN  A2000 (-4.0A)
OAN  A2000 (-4.0A)
 1.19A 3c0zA-3sutA:
undetectable		 3c0zA-3sutA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		11 / 12 ARG A 170
HIS A 196
ASP A 199
ASP A 254
HIS A 258
ASP A 321
TRP A 370
TYR A 395
ASP A 397
TRP A 441
GLU A 443
 OAN  A2000 (-2.8A)
None
OAN  A2000 ( 4.4A)
None
OAN  A2000 (-4.0A)
OAN  A2000 (-4.0A)
OAN  A2000 (-3.4A)
OAN  A2000 (-4.4A)
OAN  A2000 (-3.1A)
OAN  A2000 (-3.7A)
OAN  A2000 (-2.6A)
 0.33A 3lmyA-3sutA:
38.0		 3lmyA-3sutA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		5 / 12 ARG D  94
HIS D 169
TRP D 306
TYR D 308
TRP D 373
 OAN  D1627 (-2.8A)
OAN  D1627 ( 4.9A)
OAN  D1627 (-3.6A)
OAN  D1627 (-4.3A)
OAN  D1627 (-3.7A)
 0.67A 3lmyA-5a6bD:
27.3		 3lmyA-5a6bD:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		12 / 12 ARG A 170
HIS A 196
ASP A 199
ASP A 254
HIS A 258
ASP A 321
GLU A 322
TRP A 352
TRP A 370
TYR A 395
TRP A 441
GLU A 443
 OAN  A2000 (-2.8A)
None
OAN  A2000 ( 4.4A)
None
OAN  A2000 (-4.0A)
OAN  A2000 (-4.0A)
OAN  A2000 (-3.0A)
OAN  A2000 ( 3.9A)
OAN  A2000 (-3.4A)
OAN  A2000 (-4.4A)
OAN  A2000 (-3.7A)
OAN  A2000 (-2.6A)
 0.39A 3lmyB-3sutA:
38.1		 3lmyB-3sutA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG D  94
HIS D 169
TRP D 266
TRP D 306
TYR D 308
TRP D 373
 OAN  D1627 (-2.8A)
OAN  D1627 ( 4.9A)
OAN  D1627 (-3.6A)
OAN  D1627 (-3.6A)
OAN  D1627 (-4.3A)
OAN  D1627 (-3.7A)
 0.70A 3lmyB-5a6bD:
27.3		 3lmyB-5a6bD:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ASP A 321
GLY A 257
GLY A 285
LEU A 318
GLY A 351
 OAN  A2000 (-4.0A)
None
None
None
None
 1.23A 4blvB-3sutA:
undetectable		 4blvB-3sutA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ASP A 321
SER A 313
HIS A 194
GLY A 163
TRP A 352
 OAN  A2000 (-4.0A)
None
None
None
OAN  A2000 ( 3.9A)
 1.43A 4kn2A-3sutA:
undetectable		 4kn2A-3sutA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ASP A 321
SER A 313
HIS A 194
GLY A 163
TRP A 352
 OAN  A2000 (-4.0A)
None
None
None
OAN  A2000 ( 3.9A)
 1.42A 4kn2C-3sutA:
undetectable		 4kn2C-3sutA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 SER A 365
MET A 385
ASP A 321
 None
None
OAN  A2000 (-4.0A)
 0.96A 4mm4B-3sutA:
undetectable		 4mm4B-3sutA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 MET A 454
PHE A 445
SER A 404
ILE A 406
GLU A 443
 None
None
None
None
OAN  A2000 (-2.6A)
 1.05A 5w8aA-3sutA:
undetectable		 5w8aA-3sutA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 400
MET A 454
PHE A 445
ILE A 406
GLU A 443
 None
None
None
None
OAN  A2000 (-2.6A)
 1.44A 5w8aA-3sutA:
undetectable		 5w8aA-3sutA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 5 TRP A 352
TYR A 395
TYR A 331
HIS A 258
 OAN  A2000 ( 3.9A)
OAN  A2000 (-4.4A)
None
OAN  A2000 (-4.0A)
 1.16A 6ep4A-3sutA:
undetectable		 6ep4A-3sutA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE
(Streptococcus
pneumoniae) 		4 / 6 TYR D 308
VAL D 368
VAL D 370
THR D 371
 OAN  D1627 (-4.3A)
None
None
None
 1.33A 6f32B-5a6bD:
undetectable		 6f32B-5a6bD:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 4 GLU A 252
ASP A 167
ARG A 170
TRP A 441
 None
None
OAN  A2000 (-2.8A)
OAN  A2000 (-3.7A)
 1.04A 6mn8A-3sutA:
0.0		 6mn8A-3sutA:
22.69