SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OAF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 7 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.90A 1c9sT-3fa3A:
undetectable
1c9sU-3fa3A:
undetectable		 1c9sT-3fa3A:
12.25
1c9sU-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 12 ILE A 238
PRO A 240
ASN A 214
LEU A 212
THR A 101
 None
OAF  A 501 (-4.0A)
OAF  A 501 (-3.6A)
None
None
 0.98A 1dhfA-3fa3A:
undetectable		 1dhfA-3fa3A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 7 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.90A 1gtfL-3fa3A:
undetectable
1gtfM-3fa3A:
undetectable		 1gtfL-3fa3A:
12.25
1gtfM-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 8 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.88A 1gtfN-3fa3A:
undetectable
1gtfO-3fa3A:
undetectable		 1gtfN-3fa3A:
12.25
1gtfO-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 10 PHE A 241
GLY A 125
GLY A 192
THR A 221
ALA A 220
 None
OAF  A 501 (-3.5A)
None
None
None
 1.11A 2ej3B-3fa3A:
undetectable		 2ej3B-3fa3A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 12 ILE A 238
PRO A 240
ASN A 214
LEU A 212
THR A 101
 None
OAF  A 501 (-4.0A)
OAF  A 501 (-3.6A)
None
None
 0.97A 2w3bB-3fa3A:
undetectable		 2w3bB-3fa3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 12 ILE A 238
PRO A 240
ASN A 214
LEU A 212
THR A 101
 None
OAF  A 501 (-4.0A)
OAF  A 501 (-3.6A)
None
None
 0.97A 2w3mA-3fa3A:
undetectable		 2w3mA-3fa3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 7 GLU A 191
GLU A 116
PHE A 189
VAL A 110
 OAF  A 501 (-2.8A)
None
None
None
 1.08A 4a97D-3fa3A:
undetectable		 4a97D-3fa3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 11 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
 None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
 1.04A 4j6cA-3fa3A:
undetectable		 4j6cA-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 10 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
 None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
 1.05A 4j6cB-3fa3A:
undetectable		 4j6cB-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 12 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
 None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
 1.06A 4j6dA-3fa3A:
undetectable		 4j6dA-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 12 GLN A  57
ALA A  58
ALA A  51
ALA A  48
THR A  46
 None
None
None
OAF  A 501 (-3.4A)
OAF  A 501 (-3.3A)
 1.07A 4j6dB-3fa3A:
undetectable		 4j6dB-3fa3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 8 MET A 251
ALA A 249
PHE A 241
THR A  46
 None
None
None
OAF  A 501 (-3.3A)
 0.89A 4ltwA-3fa3A:
undetectable		 4ltwA-3fa3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 11 GLY A  47
ILE A  75
GLY A  25
ILE A 238
VAL A 110
 OAF  A 501 (-3.3A)
None
None
None
None
 0.93A 4q1xA-3fa3A:
undetectable		 4q1xA-3fa3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		5 / 10 GLY A  47
ILE A  75
GLY A  25
ILE A 238
VAL A 110
 OAF  A 501 (-3.3A)
None
None
None
None
 0.92A 4q1yA-3fa3A:
undetectable		 4q1yA-3fa3A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 8 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.90A 5eevL-3fa3A:
undetectable
5eevV-3fa3A:
undetectable		 5eevL-3fa3A:
12.25
5eevV-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 8 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.90A 5eewL-3fa3A:
undetectable
5eewV-3fa3A:
undetectable		 5eewL-3fa3A:
12.25
5eewV-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3fa3 2,3-DIMETHYLMALATE
LYASE
(Aspergillus
niger) 		4 / 8 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.90A 5ef3L-3fa3A:
undetectable
5ef3V-3fa3A:
undetectable		 5ef3L-3fa3A:
12.25
5ef3V-3fa3A:
12.25