SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'OAE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 THR A 100
GLN A 205
GLU A 133
GLY A 289
GLY A  77
 OAE  A 376 ( 3.9A)
None
OAE  A 376 (-2.6A)
OAE  A 376 ( 4.5A)
OAE  A 376 ( 3.7A)
 1.30A 1httB-3nfbA:
undetectable		 1httB-3nfbA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.15A 3ndvA-3nfbA:
68.2
3ndvB-3nfbA:
68.2		 3ndvA-3nfbA:
100.00
3ndvB-3nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.15A 3ndvA-3nfbA:
68.2
3ndvB-3nfbA:
68.2		 3ndvA-3nfbA:
100.00
3ndvB-3nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.14A 3ndvC-3nfbA:
68.1
3ndvD-3nfbA:
68.1		 3ndvC-3nfbA:
100.00
3ndvD-3nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		8 / 11 GLY A  77
THR A 100
GLU A 133
LEU A 135
ASN A 137
ASN A 207
SER A 250
LEU A 287
 OAE  A 376 ( 3.7A)
OAE  A 376 ( 3.9A)
OAE  A 376 (-2.6A)
OAE  A 376 (-3.9A)
OAE  A 376 ( 3.8A)
OAE  A 376 (-3.9A)
OAE  A 376 (-2.6A)
SO4  A 378 ( 4.2A)
 0.14A 3ndvC-3nfbA:
68.1
3ndvD-3nfbA:
68.1		 3ndvC-3nfbA:
100.00
3ndvD-3nfbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 6 PHE A 291
SER A 288
LEU A 251
LEU A 252
 None
OAE  A 376 (-4.7A)
None
None
 1.15A 5dzke-3nfbA:
undetectable
5dzks-3nfbA:
undetectable		 5dzke-3nfbA:
22.25
5dzks-3nfbA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 11 THR A 100
GLN A 205
GLU A 133
GLY A 289
GLY A  77
 OAE  A 376 ( 3.9A)
None
OAE  A 376 (-2.6A)
OAE  A 376 ( 4.5A)
OAE  A 376 ( 3.7A)
 1.29A 5e3iB-3nfbA:
undetectable		 5e3iB-3nfbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 ILE A  73
GLY A 209
GLY A 289
GLY A 278
VAL A 277
 None
None
OAE  A 376 ( 4.5A)
None
None
 0.95A 5i73A-3nfbA:
undetectable		 5i73A-3nfbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		5 / 12 ILE A  73
GLY A 209
GLY A 289
GLY A 278
VAL A 277
 None
None
OAE  A 376 ( 4.5A)
None
None
 0.96A 5i75A-3nfbA:
undetectable		 5i75A-3nfbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3nfb BETA-PEPTIDYL
AMINOPEPTIDASE
(Sphingosinicella
xenopeptidilytic
a) 		4 / 6 THR A 100
GLY A  99
GLU A 133
ILE A 184
 OAE  A 376 ( 3.9A)
None
OAE  A 376 (-2.6A)
None
 0.95A 5kmfA-3nfbA:
undetectable
5kmfC-3nfbA:
undetectable		 5kmfA-3nfbA:
22.51
5kmfC-3nfbA:
22.51