SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'O2V'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 7 SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
O2V  A1419 (-1.8A)
 1.26A 2c8aA-4uf4A:
undetectable		 2c8aA-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 7 GLY A 388
SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
None
O2V  A1419 (-1.8A)
 1.42A 2c8aB-4uf4A:
undetectable		 2c8aB-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		4 / 6 SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
O2V  A1419 (-1.8A)
 1.32A 2c8aC-4uf4A:
undetectable		 2c8aC-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 7 GLY A 388
SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
None
O2V  A1419 (-1.8A)
 1.46A 2c8aD-4uf4A:
undetectable		 2c8aD-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		3 / 3 GLU A 380
HIS A 179
GLU A 182
 O2V  A1419 (-1.8A)
ZN  A1420 ( 3.1A)
ZN  A1420 (-1.9A)
 0.83A 2x45B-4uf4A:
undetectable		 2x45B-4uf4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		3 / 3 GLU A 380
HIS A 179
GLU A 182
 O2V  A1419 (-1.8A)
ZN  A1420 ( 3.1A)
ZN  A1420 (-1.9A)
 0.86A 2x45C-4uf4A:
undetectable		 2x45C-4uf4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens) 		5 / 12 GLY A 260
GLY A 265
GLY A 262
ALA A 360
TYR A 358
 None
None
None
O2V  A1419 ( 3.7A)
O2V  A1419 (-4.6A)
 0.81A 5x7fA-4uf4A:
undetectable		 5x7fA-4uf4A:
20.75