SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'O16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	11GS_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 7	TYR A 8 PHE A 9 GLY A 13 ARG A 14	None O16 A3201 (-3.0A) O16 A3201 ( 3.7A) O16 A3201 ( 3.8A)	0.38A	11gsB-1v40A: 24.5	11gsB-1v40A: 27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_A_EAAA0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 8	TYR A 8 PHE A 9 ARG A 14 TRP A 39	None O16 A3201 (-3.0A) O16 A3201 ( 3.8A) GSH A3200 (-4.1A)	0.68A	2gssA-1v40A: 24.5	2gssA-1v40A: 27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_B_EAAB0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 8	TYR A 8 PHE A 9 ARG A 14 TRP A 39	None O16 A3201 (-3.0A) O16 A3201 ( 3.8A) GSH A3200 (-4.1A)	0.68A	2gssB-1v40A: 24.5	2gssB-1v40A: 27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VD0_B_D27B1200_0 (GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	10 / 10	MET A 11 GLY A 13 ARG A 14 MET A 99 TRP A 104 ALA A 105 TYR A 152 CYH A 156 THR A 159 LEU A 199	O16 A3201 ( 3.9A) O16 A3201 ( 3.7A) O16 A3201 ( 3.8A) O16 A3201 (-4.7A) O16 A3201 (-4.0A) O16 A3201 (-3.0A) O16 A3201 (-4.9A) O16 A3201 (-3.6A) O16 A3201 ( 4.8A) O16 A3201 (-3.8A)	0.65A	2vd0B-1v40A: 34.3	2vd0B-1v40A: 99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZI9_A_CL9A401_2 (DEOXYCYTIDINE KINASE)	6fos	PSAM (Cyanidioschyzon merolae)	3 / 3	ASP O 118 PHE O 121 LEU O 125	None None CLA O1602 (-3.9A)	0.30A	2zi9A-6fosO: undetectable	2zi9A-6fosO: 13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N9J_A_EAAA210_1 (GLUTATHIONE S-TRANSFERASE P)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 8	TYR A 8 PHE A 9 ARG A 14 TRP A 39	None O16 A3201 (-3.0A) O16 A3201 ( 3.8A) GSH A3200 (-4.1A)	0.70A	3n9jA-1v40A: 24.4	3n9jA-1v40A: 27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N9J_B_EAAB214_1 (GLUTATHIONE S-TRANSFERASE P)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 8	TYR A 8 PHE A 9 GLY A 13 ARG A 14	None O16 A3201 (-3.0A) O16 A3201 ( 3.7A) O16 A3201 ( 3.8A)	0.39A	3n9jB-1v40A: 24.4	3n9jB-1v40A: 27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_D_W9TD507_1 (HEMOLYTIC LECTIN CEL-III)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 5	GLU A 16 GLY A 13 TYR A 152 ASP A 96	None O16 A3201 ( 3.7A) O16 A3201 (-4.9A) O16 A3201 ( 4.8A)	1.32A	3w9tD-1v40A: undetectable	3w9tD-1v40A: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D39_A_MTLA870_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 8	SER A 64 ARG A 14 ILE A 17 TRP A 148	GSH A3200 (-2.5A) O16 A3201 ( 3.8A) None None	1.06A	4d39A-1v40A: undetectable	4d39A-1v40A: 18.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["11GS_B_EAAB211_1","GLUTATHIONE S-TRANSFERASE","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"TYR A   8;PHE A   9;GLY A  13;ARG A  14","None;O16 A3201 (-3.0A);O16 A3201 ( 3.7A);O16 A3201 ( 3.8A)","0.38A","11gsB-1v40A:24.5",null],["2GSS_A_EAAA0_1","GLUTATHIONE S-TRANSFERASE P1-1","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"TYR A   8;PHE A   9;ARG A  14;TRP A  39","None;O16 A3201 (-3.0A);O16 A3201 ( 3.8A);GSH A3200 (-4.1A)","0.68A","2gssA-1v40A:24.5","11gsB-1v40A:27.03"],["2GSS_B_EAAB0_1","GLUTATHIONE S-TRANSFERASE P1-1","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"TYR A   8;PHE A   9;ARG A  14;TRP A  39","None;O16 A3201 (-3.0A);O16 A3201 ( 3.8A);GSH A3200 (-4.1A)","0.68A","2gssB-1v40A:24.5","2gssA-1v40A:27.03"],["2VD0_B_D27B1200_0","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",10,"MET A  11;GLY A  13;ARG A  14;MET A  99;TRP A 104;ALA A 105;TYR A 152;CYH A 156;THR A 159;LEU A 199","O16 A3201 ( 3.9A);O16 A3201 ( 3.7A);O16 A3201 ( 3.8A);O16 A3201 (-4.7A);O16 A3201 (-4.0A);O16 A3201 (-3.0A);O16 A3201 (-4.9A);O16 A3201 (-3.6A);O16 A3201 ( 4.8A);O16 A3201 (-3.8A)","0.65A","2vd0B-1v40A:34.3","2gssB-1v40A:27.03"],["2ZI9_A_CL9A401_2","DEOXYCYTIDINE KINASE","6fos","PSAM","Cyanidioschyzon merolae",3,"ASP O 118;PHE O 121;LEU O 125","None;None;CLA O1602 (-3.9A)","0.30A","2zi9A-6fosO:undetectable","2vd0B-1v40A:99.49"],["3N9J_A_EAAA210_1","GLUTATHIONE S-TRANSFERASE P","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"TYR A   8;PHE A   9;ARG A  14;TRP A  39","None;O16 A3201 (-3.0A);O16 A3201 ( 3.8A);GSH A3200 (-4.1A)","0.70A","3n9jA-1v40A:24.4","2zi9A-6fosO:13.60"],["3N9J_B_EAAB214_1","GLUTATHIONE S-TRANSFERASE P","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"TYR A   8;PHE A   9;GLY A  13;ARG A  14","None;O16 A3201 (-3.0A);O16 A3201 ( 3.7A);O16 A3201 ( 3.8A)","0.39A","3n9jB-1v40A:24.4","3n9jA-1v40A:27.03"],["3W9T_D_W9TD507_1","HEMOLYTIC LECTIN CEL-III","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"GLU A  16;GLY A  13;TYR A 152;ASP A  96","None;O16 A3201 ( 3.7A);O16 A3201 (-4.9A);O16 A3201 ( 4.8A)","1.32A","3w9tD-1v40A:undetectable","3n9jB-1v40A:27.03"],["4D39_A_MTLA870_0","NITRIC OXIDE SYNTHASE, ENDOTHELIAL","1v40","GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE","Homo sapiens",4,"SER A  64;ARG A  14;ILE A  17;TRP A 148","GSH A3200 (-2.5A);O16 A3201 ( 3.8A);None;None","1.06A","4d39A-1v40A:undetectable","3w9tD-1v40A:17.70"]]