SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NZU'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOG_A_C2FA302_0 (THYMIDYLATE SYNTHASE)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	5 / 11	HIS A 962 ILE A 963 ASP A 836 GLY A 966 PHE A 965	None NZU A 1 (-3.7A) None None None	1.36A	4fogA-3nzuA: undetectable	4fogA-3nzuA: 14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_F_D16F301_1 (THYMIDYLATE SYNTHASE)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	5 / 11	HIS A 962 ILE A 963 ASP A 836 GLY A 966 PHE A 965	None NZU A 1 (-3.7A) None None None	1.47A	4foxF-3nzuA: undetectable	4foxF-3nzuA: 14.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	5 / 12	ILE A 879 VAL A 882 THR A 887 MET A 953 ILE A 963	NZU A 1 (-4.2A) NZU A 1 (-3.9A) NZU A 1 (-3.8A) NZU A 1 (-3.5A) NZU A 1 (-3.7A)	0.98A	4xe0A-3nzuA: 33.3	4xe0A-3nzuA: 35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	6 / 12	MET A 804 PRO A 810 TYR A 867 VAL A 882 MET A 953 ILE A 963	NZU A 1 (-4.7A) None NZU A 1 (-3.5A) NZU A 1 (-3.9A) NZU A 1 (-3.5A) NZU A 1 (-3.7A)	1.29A	4xe0A-3nzuA: 33.3	4xe0A-3nzuA: 35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	5 / 12	PRO A 810 ILE A 831 THR A 887 ILE A 963 ASP A 964	None NZU A 1 (-4.9A) NZU A 1 (-3.8A) NZU A 1 (-3.7A) NZU A 1 (-4.1A)	0.87A	4xe0A-3nzuA: 33.3	4xe0A-3nzuA: 35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	8 / 12	PRO A 810 TRP A 812 ILE A 831 TYR A 867 VAL A 882 THR A 887 MET A 953 ILE A 963	None None NZU A 1 (-4.9A) NZU A 1 (-3.5A) NZU A 1 (-3.9A) NZU A 1 (-3.8A) NZU A 1 (-3.5A) NZU A 1 (-3.7A)	0.46A	4xe0A-3nzuA: 33.3	4xe0A-3nzuA: 35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DH0_A_017A101_2 (PROTEASE)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	3 / 3	LEU A 843 ASP A 964 ILE A 879	None NZU A 1 (-4.1A) NZU A 1 (-4.2A)	0.60A	6dh0B-3nzuA: undetectable	6dh0B-3nzuA: 6.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4FOG_A_C2FA302_0","THYMIDYLATE SYNTHASE","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",5,"HIS A 962;ILE A 963;ASP A 836;GLY A 966;PHE A 965","None;NZU A   1 (-3.7A);None;None;None","1.36A","4fogA-3nzuA:undetectable",null],["4FOX_F_D16F301_1","THYMIDYLATE SYNTHASE","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",5,"HIS A 962;ILE A 963;ASP A 836;GLY A 966;PHE A 965","None;NZU A   1 (-3.7A);None;None;None","1.47A","4foxF-3nzuA:undetectable","4fogA-3nzuA:14.36"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",5,"ILE A 879;VAL A 882;THR A 887;MET A 953;ILE A 963","NZU A   1 (-4.2A);NZU A   1 (-3.9A);NZU A   1 (-3.8A);NZU A   1 (-3.5A);NZU A   1 (-3.7A)","0.98A","4xe0A-3nzuA:33.3","4foxF-3nzuA:14.36"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",6,"MET A 804;PRO A 810;TYR A 867;VAL A 882;MET A 953;ILE A 963","NZU A   1 (-4.7A);None;NZU A   1 (-3.5A);NZU A   1 (-3.9A);NZU A   1 (-3.5A);NZU A   1 (-3.7A)","1.29A","4xe0A-3nzuA:33.3","4xe0A-3nzuA:35.86"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",5,"PRO A 810;ILE A 831;THR A 887;ILE A 963;ASP A 964","None;NZU A   1 (-4.9A);NZU A   1 (-3.8A);NZU A   1 (-3.7A);NZU A   1 (-4.1A)","0.87A","4xe0A-3nzuA:33.3","4xe0A-3nzuA:35.86"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",8,"PRO A 810;TRP A 812;ILE A 831;TYR A 867;VAL A 882;THR A 887;MET A 953;ILE A 963","None;None;NZU A   1 (-4.9A);NZU A   1 (-3.5A);NZU A   1 (-3.9A);NZU A   1 (-3.8A);NZU A   1 (-3.5A);NZU A   1 (-3.7A)","0.46A","4xe0A-3nzuA:33.3","4xe0A-3nzuA:35.86"],["6DH0_A_017A101_2","PROTEASE","3nzu","PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM","Homo sapiens",3,"LEU A 843;ASP A 964;ILE A 879","None;NZU A   1 (-4.1A);NZU A   1 (-4.2A)","0.60A","6dh0B-3nzuA:undetectable","4xe0A-3nzuA:35.86"]]