SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NXX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nuq FKSG76
(Homo
sapiens) 		3 / 3 THR A  93
LEU A  97
LEU A 104
 NXX  A 401 (-4.3A)
None
None
 0.57A 1mz9C-1nuqA:
undetectable		 1mz9C-1nuqA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 498
THR A 492
LEU A 466
 None
NXX  A 680 (-4.0A)
None
 0.55A 3ondA-3dlaA:
3.7		 3ondA-3dlaA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 498
THR A 492
LEU A 466
 None
NXX  A 680 (-4.0A)
None
 0.56A 3ondB-3dlaA:
4.8		 3ondB-3dlaA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 458
LEU A 461
ASP A 497
ASP A 482
 None
None
NXX  A 680 (-2.7A)
None
 1.10A 4qtuD-3dlaA:
3.0		 4qtuD-3dlaA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1nuq FKSG76
(Homo
sapiens) 		4 / 6 CYH A 134
LEU A 139
HIS A 190
LEU A 162
 NXX  A 401 (-4.8A)
None
None
None
 1.11A 5hpuC-1nuqA:
undetectable
5hpuD-1nuqA:
undetectable		 5hpuC-1nuqA:
6.70
5hpuD-1nuqA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1nuq FKSG76
(Homo
sapiens) 		4 / 7 GLY A  13
PHE A  15
HIS A  22
SER A 201
 NXX  A 401 (-3.2A)
NXX  A 401 (-4.5A)
NXX  A 401 (-4.3A)
SO4  A 302 ( 4.1A)
 0.70A 6jnhA-1nuqA:
15.0		 6jnhA-1nuqA:
23.64