SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NXL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 10 GLY A  63
GLN A 120
ASN A 152
TYR A 222
THR A 315
GLY A 316
 NXL  A 401 (-3.8A)
NXL  A 401 ( 3.3A)
NXL  A 401 (-3.6A)
EPE  A 405 (-4.0A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
 1.29A 1kvlA-5za2A:
55.2		 1kvlA-5za2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		8 / 10 LEU A 119
GLN A 120
TYR A 150
ASN A 152
TYR A 222
LYS A 314
THR A 315
GLY A 316
 NXL  A 401 (-4.6A)
NXL  A 401 ( 3.3A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.6A)
EPE  A 405 (-4.0A)
NXL  A 401 (-2.9A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
 0.28A 1kvlA-5za2A:
55.2		 1kvlA-5za2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		7 / 10 GLY A  61
LEU A 117
GLN A 118
ASN A 150
TYR A 220
THR A 313
GLY A 314
 NXL  A 401 ( 3.9A)
None
NXL  A 401 (-3.3A)
NXL  A 401 (-3.5A)
NXL  A 401 ( 4.7A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
 1.21A 1kvlA-6fm7A:
55.1		 1kvlA-6fm7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		8 / 10 LEU A 117
GLN A 118
TYR A 148
ASN A 150
TYR A 220
LYS A 312
THR A 313
GLY A 314
 None
NXL  A 401 (-3.3A)
NXL  A 401 (-4.1A)
NXL  A 401 (-3.5A)
NXL  A 401 ( 4.7A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
 0.28A 1kvlA-6fm7A:
55.1		 1kvlA-6fm7A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 ILE A  62
GLY A  63
GLY A 319
ALA A 221
LEU A  69
 None
NXL  A 401 (-3.8A)
EPE  A 405 (-4.0A)
None
None
 1.04A 1vptA-5za2A:
undetectable		 1vptA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 SER A  62
LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 (-1.4A)
NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.43A 1ymxB-6fm7A:
15.4		 1ymxB-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.52A 3hlwA-6fm7A:
15.4		 3hlwA-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		5 / 12 LYS A  67
ASN A 152
LYS A 314
THR A 315
GLY A 316
 NXL  A 401 ( 3.8A)
NXL  A 401 (-3.6A)
NXL  A 401 (-2.9A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
 0.32A 3huoA-5za2A:
15.6		 3huoA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 LYS A  65
ASN A 150
LYS A 312
THR A 313
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.48A 3huoA-6fm7A:
15.5		 3huoA-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.49A 3huoB-6fm7A:
15.2		 3huoB-6fm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 316
THR A 318
ARG A 348
 NXL  A 401 (-1.3A)
NXL  A 401 ( 3.8A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.4A)
EPE  A 405 (-4.1A)
None
 0.97A 3mzeA-5za2A:
14.8		 3mzeA-5za2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5za2 BETA-LACTAMASE
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 315
GLY A 316
THR A 318
 NXL  A 401 (-1.3A)
NXL  A 401 ( 3.8A)
NXL  A 401 (-3.6A)
NXL  A 401 (-4.0A)
NXL  A 401 (-3.4A)
EPE  A 405 (-4.1A)
 0.67A 3mzeA-5za2A:
14.8		 3mzeA-5za2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 SER A  62
LYS A  65
ASN A 150
GLY A 314
THR A 316
ARG A 346
 NXL  A 401 (-1.4A)
NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
None
None
 0.98A 3mzeA-6fm7A:
14.7		 3mzeA-6fm7A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		6 / 12 SER A  62
LYS A  65
ASN A 150
THR A 313
GLY A 314
THR A 316
 NXL  A 401 (-1.4A)
NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.3A)
None
 0.68A 3mzeA-6fm7A:
14.7		 3mzeA-6fm7A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.55A 3q07A-6fm7A:
15.3		 3q07A-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 LYS A  65
ASN A 150
LYS A 312
GLY A 314
SER A 315
 NXL  A 401 ( 3.9A)
NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
 0.52A 3q07B-6fm7A:
15.2		 3q07B-6fm7A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 6fm7 BETA-LACTAMASE
(Aeromonas
enteropelogenes) 		5 / 12 ASN A 150
LYS A 312
GLY A 314
SER A 315
ASN A 340
 NXL  A 401 (-3.5A)
NXL  A 401 (-3.6A)
NXL  A 401 (-3.3A)
NXL  A 401 (-3.4A)
SO4  A 403 (-4.0A)
 0.78A 6c79A-6fm7A:
15.4		 6c79A-6fm7A:
24.44