SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NTM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 VAL A  58
GLY A  57
GLY A 258
HIS A 173
GLU A 198
 None
None
None
NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
 1.24A 1iolA-4zk6A:
undetectable		 1iolA-4zk6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.44A 1j36A-4zk6A:
undetectable		 1j36A-4zk6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.44A 1j36B-4zk6A:
undetectable		 1j36B-4zk6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.39A 1o86A-4zk6A:
undetectable		 1o86A-4zk6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		3 / 3 GLU A 198
HIS A 173
HIS A 196
 NTM  A 402 (-3.2A)
NTM  A 402 (-4.6A)
NTM  A 402 ( 3.7A)
 0.70A 1oe2A-4zk6A:
undetectable		 1oe2A-4zk6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.46A 2c6nB-4zk6A:
undetectable		 2c6nB-4zk6A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		3 / 3 HIS A  21
MET A  61
MET A 259
 NTM  A 402 ( 3.9A)
NTM  A 402 (-3.5A)
None
 1.28A 2vj1A-4zk6A:
undetectable		 2vj1A-4zk6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.37A 2x8zA-4zk6A:
undetectable		 2x8zA-4zk6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.37A 2x91A-4zk6A:
undetectable		 2x91A-4zk6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2b7n PROBABLE
NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Helicobacter
pylori) 		5 / 12 ILE A 205
ALA A 203
LEU A 172
LEU A 157
ARG A 148
 None
None
None
None
NTM  A1001 (-3.6A)
 1.13A 3ix9A-2b7nA:
undetectable		 3ix9A-2b7nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.09A 3olsA-4zk6A:
undetectable		 3olsA-4zk6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 254
MET A 174
ASP A 227
GLY A 257
SER A 276
 NTM  A 300 ( 4.5A)
NTM  A 300 (-3.6A)
None
None
NTM  A 300 (-3.7A)
 1.33A 4djeB-3c2oA:
2.7		 4djeB-3c2oA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.13A 4pxmA-4zk6A:
undetectable		 4pxmA-4zk6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.14A 4pxmB-4zk6A:
undetectable		 4pxmB-4zk6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
TYR A  23
SER A  38
ALA A  62
GLU A  63
 None
SF4  A 401 (-4.8A)
NTM  A 402 ( 2.5A)
None
None
 1.28A 4ymgA-4zk6A:
undetectable		 4ymgA-4zk6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 10 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.13A 5dx3A-4zk6A:
undetectable		 5dx3A-4zk6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.14A 5dxgB-4zk6A:
undetectable		 5dxgB-4zk6A:
22.29