SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NSS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 211
GLU A 230
TYR A 333
GLY A 361
GLY A 401
 NSS  A3002 (-2.9A)
None
None
NSS  A3002 ( 4.2A)
NSS  A3002 ( 4.9A)
 0.98A 1httB-1x55A:
14.8		 1httB-1x55A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		5 / 12 ARG A 321
GLU A 340
TYR A 448
GLY A 475
GLY A 515
 NSS  A1550 (-2.9A)
None
None
NSS  A1550 ( 4.1A)
None
 1.01A 1httB-2xgtA:
14.5		 1httB-2xgtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 211
GLU A 230
TYR A 333
GLY A 361
GLY A 401
 NSS  A3002 (-2.9A)
None
None
NSS  A3002 ( 4.2A)
NSS  A3002 ( 4.9A)
 1.03A 1httD-1x55A:
14.8		 1httD-1x55A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		5 / 12 ARG A 321
GLU A 340
TYR A 448
GLY A 475
GLY A 515
 NSS  A1550 (-2.9A)
None
None
NSS  A1550 ( 4.1A)
None
 1.06A 1httD-2xgtA:
14.5		 1httD-2xgtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 165
LEU A 191
TYR A 385
GLY A 169
GLU A 228
 None
None
None
None
NSS  A3002 (-3.8A)
 1.22A 1iolA-1x55A:
undetectable		 1iolA-1x55A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		4 / 6 GLU A 421
GLU A 424
ARG A 522
GLU A 471
 None
None
NSS  A1550 (-4.1A)
MG  A1551 ( 2.6A)
 1.34A 4kr3A-2xgtA:
11.4		 4kr3A-2xgtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 309
GLY A 354
GLU A 353
LEU A 221
HIS A 220
 None
None
None
NSS  A3002 (-4.7A)
PO4  A3001 ( 4.1A)
 0.99A 4wcxC-1x55A:
undetectable		 4wcxC-1x55A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 211
GLU A 230
TYR A 333
GLY A 361
GLY A 401
 NSS  A3002 (-2.9A)
None
None
NSS  A3002 ( 4.2A)
NSS  A3002 ( 4.9A)
 0.97A 5e3iA-1x55A:
14.6		 5e3iA-1x55A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		5 / 12 ARG A 321
GLU A 340
TYR A 448
GLY A 475
GLY A 515
 NSS  A1550 (-2.9A)
None
None
NSS  A1550 ( 4.1A)
None
 1.01A 5e3iA-2xgtA:
14.3		 5e3iA-2xgtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ARG A 211
GLU A 230
TYR A 333
GLY A 361
GLY A 401
 NSS  A3002 (-2.9A)
None
None
NSS  A3002 ( 4.2A)
NSS  A3002 ( 4.9A)
 1.01A 5e3iB-1x55A:
14.5		 5e3iB-1x55A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		5 / 11 ARG A 321
GLU A 340
TYR A 448
GLY A 475
GLY A 515
 NSS  A1550 (-2.9A)
None
None
NSS  A1550 ( 4.1A)
None
 1.04A 5e3iB-2xgtA:
14.1		 5e3iB-2xgtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLN A 187
GLY A 361
GLY A 403
VAL A 167
ALA A 331
 None
NSS  A3002 ( 4.2A)
NSS  A3002 (-3.6A)
None
None
 1.13A 5o96E-1x55A:
undetectable
5o96F-1x55A:
undetectable		 5o96E-1x55A:
18.40
5o96F-1x55A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		5 / 10 GLN A 297
GLY A 475
GLY A 517
VAL A 277
ALA A 446
 None
NSS  A1550 ( 4.1A)
NSS  A1550 (-3.7A)
None
None
 1.16A 5o96E-2xgtA:
undetectable
5o96F-2xgtA:
undetectable		 5o96E-2xgtA:
20.00
5o96F-2xgtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 357
ARG A 408
GLY A 405
GLY A 361
ARG A 211
 MG  A2001 (-2.6A)
PO4  A3001 ( 3.2A)
NSS  A3002 (-3.2A)
NSS  A3002 ( 4.2A)
NSS  A3002 (-2.9A)
 1.12A 5vooA-1x55A:
undetectable		 5vooA-1x55A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 357
ARG A 408
GLY A 405
GLY A 361
ARG A 211
 MG  A2001 (-2.6A)
PO4  A3001 ( 3.2A)
NSS  A3002 (-3.2A)
NSS  A3002 ( 4.2A)
NSS  A3002 (-2.9A)
 1.14A 5vooC-1x55A:
undetectable		 5vooC-1x55A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		7 / 10 ARG A 211
HIS A 220
PHE A 224
GLU A 357
GLY A 405
ARG A 408
ILE A 419
 NSS  A3002 (-2.9A)
PO4  A3001 ( 4.1A)
NSS  A3002 (-3.4A)
MG  A2001 (-2.6A)
NSS  A3002 (-3.2A)
PO4  A3001 ( 3.2A)
None
 0.90A 6bniA-1x55A:
31.0		 6bniA-1x55A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		6 / 10 ARG A 321
GLU A 323
HIS A 330
GLY A 519
ARG A 522
ILE A 533
 NSS  A1550 (-2.9A)
NSS  A1550 (-3.5A)
NSS  A1550 (-4.6A)
NSS  A1550 (-3.5A)
NSS  A1550 (-4.1A)
None
 0.64A 6bniA-2xgtA:
30.6		 6bniA-2xgtA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		6 / 10 GLU A 323
HIS A 330
GLU A 471
GLY A 519
ARG A 522
ILE A 533
 NSS  A1550 (-3.5A)
NSS  A1550 (-4.6A)
MG  A1551 ( 2.6A)
NSS  A1550 (-3.5A)
NSS  A1550 (-4.1A)
None
 0.70A 6bniA-2xgtA:
30.6		 6bniA-2xgtA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1x55 ASPARAGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		7 / 10 ARG A 211
HIS A 220
PHE A 224
GLU A 357
GLY A 405
ARG A 408
ILE A 419
 NSS  A3002 (-2.9A)
PO4  A3001 ( 4.1A)
NSS  A3002 (-3.4A)
MG  A2001 (-2.6A)
NSS  A3002 (-3.2A)
PO4  A3001 ( 3.2A)
None
 0.87A 6bniB-1x55A:
31.0		 6bniB-1x55A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		7 / 10 ARG A 321
GLU A 323
HIS A 330
GLU A 471
GLY A 519
ARG A 522
ILE A 533
 NSS  A1550 (-2.9A)
NSS  A1550 (-3.5A)
NSS  A1550 (-4.6A)
MG  A1551 ( 2.6A)
NSS  A1550 (-3.5A)
NSS  A1550 (-4.1A)
None
 0.75A 6bniB-2xgtA:
30.6		 6bniB-2xgtA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Brugia
malayi) 		5 / 12 GLY A 279
HIS A 336
LEU A 301
ILE A 494
TYR A 334
 None
NSS  A1550 (-4.2A)
None
None
NSS  A1550 (-3.5A)
 1.19A 6md4A-2xgtA:
undetectable		 6md4A-2xgtA:
10.40