SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NSQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5ohs -
(-) 		5 / 11 ARG A 283
VAL A 138
GLY A 137
LEU A 494
SER A 279
 NSQ  A 709 (-3.3A)
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
 1.14A 2bxeA-5ohsA:
undetectable		 2bxeA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 ARG A 301
VAL A 155
GLY A 154
ALA A 167
LEU A 511
 NSQ  A1681 (-3.1A)
CA  A1679 ( 4.7A)
CA  A1679 (-4.6A)
None
None
 1.16A 2bxgA-5aeeA:
undetectable		 2bxgA-5aeeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 ARG A 301
VAL A 155
GLY A 154
LEU A 511
SER A 297
 NSQ  A1681 (-3.1A)
CA  A1679 ( 4.7A)
CA  A1679 (-4.6A)
None
None
 1.22A 2bxgA-5aeeA:
undetectable		 2bxgA-5aeeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5ohs -
(-) 		5 / 11 ARG A 283
VAL A 138
GLY A 137
LEU A 494
SER A 279
 NSQ  A 709 (-3.3A)
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
 1.13A 2bxgA-5ohsA:
undetectable		 2bxgA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ohs -
(-) 		3 / 3 SER A 559
HIS A 484
ASP A 487
 None
None
NSQ  A 709 ( 4.8A)
 0.74A 2oxtA-5ohsA:
undetectable		 2oxtA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 VAL A 302
ARG A 455
TRP A 469
THR A 509
 NSQ  A1681 (-3.5A)
NSQ  A1681 (-3.7A)
NSQ  A1681 (-4.8A)
None
 1.09A 2x2iA-5aeeA:
25.7		 2x2iA-5aeeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		3 / 3 MET A 403
GLU A 408
ASN A  54
 NSQ  A1681 (-3.6A)
None
None
 0.81A 3a27A-5aeeA:
undetectable		 3a27A-5aeeA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5ohs -
(-) 		3 / 3 MET A 386
GLU A 391
ASN A  44
 NSQ  A 709 (-3.5A)
None
EDO  A 708 ( 4.7A)
 0.83A 3a27A-5ohsA:
undetectable		 3a27A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 ASP A 405
TRP A 433
ILE A 334
SER A 291
 NSQ  A1681 (-3.3A)
None
None
None
 1.36A 3ckzA-5aeeA:
2.0		 3ckzA-5aeeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5ohs -
(-) 		5 / 9 ALA A 387
ASP A 388
GLY A 314
LEU A 313
VAL A 424
 None
NSQ  A 709 (-3.3A)
None
None
None
 0.95A 3em4B-5ohsA:
undetectable		 3em4B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ohs -
(-) 		5 / 12 LEU A 284
VAL A 138
SER A 153
ASN A 523
TYR A 491
 NSQ  A 709 (-3.6A)
None
MPD  A 705 (-3.0A)
None
NSQ  A 709 (-4.2A)
 1.48A 4amjB-5ohsA:
undetectable		 4amjB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 4 ARG A 455
TRP A 469
ASP A 504
ARG A 535
 NSQ  A1681 (-3.7A)
NSQ  A1681 (-4.8A)
NSQ  A1681 ( 4.7A)
None
 0.85A 5iefA-5aeeA:
26.7		 5iefA-5aeeA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5ohs -
(-) 		4 / 4 ARG A 438
TRP A 452
ASP A 487
ARG A 518
 NSQ  A 709 (-3.8A)
NSQ  A 709 (-4.9A)
NSQ  A 709 ( 4.8A)
None
 0.87A 5iefA-5ohsA:
28.0		 5iefA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ohs -
(-) 		5 / 12 GLU A 270
ASP A 487
ALA A 439
ASN A 164
PHE A 389
 NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
None
None
NSQ  A 709 ( 4.8A)
 1.35A 5kc4E-5ohsA:
undetectable		 5kc4E-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5ohs -
(-) 		4 / 8 GLY A 440
ILE A 451
TRP A 452
GLN A 456
 None
None
NSQ  A 709 (-4.9A)
None
 0.97A 5vlmD-5ohsA:
undetectable		 5vlmD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5ohs -
(-) 		4 / 8 GLY A 440
ILE A 451
TRP A 452
GLN A 456
 None
None
NSQ  A 709 (-4.9A)
None
 0.95A 5vlmH-5ohsA:
undetectable		 5vlmH-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.35A 5x7pA-5ohsA:
22.2		 5x7pA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.31A 5x7pB-5ohsA:
22.1		 5x7pB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.34A 5x7qA-5ohsA:
18.8		 5x7qA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.37A 5x7qB-5ohsA:
22.2		 5x7qB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.32A 5x7rA-5ohsA:
21.9		 5x7rA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.31A 5x7rB-5ohsA:
22.3		 5x7rB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 ALA A 287
GLN A 262
TRP A 286
ASP A 504
 None
None
None
NSQ  A1681 ( 4.7A)
 1.41A 5y9aA-5aeeA:
undetectable		 5y9aA-5aeeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5ohs -
(-) 		5 / 12 ASP A 487
HIS A 520
GLU A 391
GLU A 117
GLY A 472
 NSQ  A 709 ( 4.8A)
NSQ  A 709 (-3.9A)
None
None
None
 1.48A 6gnfC-5ohsA:
undetectable		 6gnfC-5ohsA:
undetectable