SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NRQ'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor)
4 / 7 HIS A 197
THR A 108
TRP A  90
TYR A 178
NRQ  A  63 (-3.6A)
None
NRQ  A  63 ( 4.1A)
None
1.33A 1afsB-1uisA:
undetectable
1afsB-1uisA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
5 / 12 ILE A 262
TYR A  88
VAL A  92
ILE A  76
LEU A 218
None
None
None
NRQ  A 224 ( 4.7A)
None
1.21A 1fm4A-4i2yA:
undetectable
1fm4A-4i2yA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)
5ukg K-GECO
(Entacmaea
quadricolor)
4 / 8 LEU A  63
SER A 265
ASN A  32
GLN A 273
None
None
NRQ  A 186 ( 3.6A)
None
1.14A 1ig3A-5ukgA:
undetectable
1ig3B-5ukgA:
undetectable
1ig3A-5ukgA:
20.44
1ig3B-5ukgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
5ukg K-GECO
(Entacmaea
quadricolor)
4 / 7 GLN A 273
LEU A  63
SER A 265
ASN A  32
None
None
None
NRQ  A 186 ( 3.6A)
1.25A 1ig3A-5ukgA:
undetectable
1ig3B-5ukgA:
undetectable
1ig3A-5ukgA:
20.44
1ig3B-5ukgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata)
5 / 12 MET L  41
CYH L  26
ILE A 121
PHE L  24
LEU L  51
NRQ  A  65 ( 3.5A)
None
None
None
None
1.42A 1m2zD-3cfhL:
undetectable
1m2zD-3cfhL:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata)
4 / 7 GLU A 145
GLU A 195
ILE A  70
LEU A 154
NRQ  A  65 ( 3.3A)
None
None
None
1.25A 1q0yH-3cfhA:
undetectable
1q0yL-3cfhA:
undetectable
1q0yH-3cfhA:
22.64
1q0yL-3cfhA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)
3u0n MRUBY
(Entacmaea
quadricolor)
5 / 12 ALA A  54
GLU A 208
SER A  61
LEU A 199
TYR A  96
None
None
None
NRQ  A  64 ( 3.0A)
None
1.34A 1u72A-3u0nA:
undetectable
1u72A-3u0nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata)
5 / 9 GLU A 195
GLU A 145
MET A 160
LEU A 159
GLU A 214
None
NRQ  A  65 ( 3.3A)
NRQ  A  65 ( 3.6A)
None
NRQ  A  65 ( 3.1A)
1.29A 1wrlA-3cfhA:
undetectable
1wrlB-3cfhA:
undetectable
1wrlA-3cfhA:
18.63
1wrlB-3cfhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata)
5 / 10 GLU A 195
GLU A 145
MET A 160
LEU A 159
GLU A 214
None
NRQ  A  65 ( 3.3A)
NRQ  A  65 ( 3.6A)
None
NRQ  A  65 ( 3.1A)
1.42A 1wrlE-3cfhA:
undetectable
1wrlF-3cfhA:
undetectable
1wrlE-3cfhA:
18.63
1wrlF-3cfhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor)
4 / 6 ARG A 197
GLY A 156
THR A 176
ARG A  92
NRQ  A  63 ( 3.9A)
None
None
NRQ  A  63 ( 2.6A)
1.08A 2f7fA-3bxaA:
undetectable
2f7fA-3bxaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor)
4 / 6 ARG A  30
GLY A 226
THR A   9
ARG A 162
NRQ  A 133 ( 3.8A)
None
None
NRQ  A 133 ( 2.7A)
1.00A 2f7fA-3rwaA:
undetectable
2f7fA-3rwaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli)
4 / 6 ARG A 201
GLY A 160
THR A 180
ARG A  96
NRQ  A  67 ( 3.8A)
None
None
NRQ  A  67 ( 2.5A)
1.03A 2f7fA-5bqlA:
undetectable
2f7fA-5bqlA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
5lk4 MSCARLET
(Discosoma
sp.)
4 / 6 ARG A 198
GLY A 160
THR A 180
ARG A  96
NRQ  A  67 ( 4.3A)
None
None
NRQ  A  67 ( 3.0A)
1.03A 2f7fA-5lk4A:
undetectable
2f7fA-5lk4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor)
3 / 3 ILE A  70
VAL A 195
ARG A 197
None
None
NRQ  A  63 ( 3.9A)
0.49A 3p73A-3bxaA:
1.4
3p73A-3bxaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli)
4 / 8 ARG A 201
ALA A 223
LEU A  80
ASP A  82
NRQ  A  67 ( 3.8A)
None
None
None
0.78A 3qj7A-5bqlA:
undetectable
3qj7D-5bqlA:
undetectable
3qj7A-5bqlA:
20.58
3qj7D-5bqlA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
5 / 12 ILE A 262
TYR A  88
VAL A  92
ILE A  76
LEU A 218
None
None
None
NRQ  A 224 ( 4.7A)
None
1.24A 4a84A-4i2yA:
undetectable
4a84A-4i2yA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)
5lk4 MSCARLET
(Discosoma
sp.)
4 / 5 ARG A 198
TYR A  84
TYR A 182
LEU A 158
NRQ  A  67 ( 4.3A)
None
None
None
1.35A 4f8yA-5lk4A:
undetectable
4f8yB-5lk4A:
undetectable
4f8yA-5lk4A:
21.28
4f8yB-5lk4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)
5lk4 MSCARLET
(Discosoma
sp.)
5 / 9 VAL A 212
VAL A 211
ILE A  30
GLY A  32
ALA A  45
None
None
None
None
NRQ  A  67 ( 3.3A)
1.12A 4fwdA-5lk4A:
undetectable
4fwdA-5lk4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
5lk4 MSCARLET
(Discosoma
sp.)
5 / 12 PHE A  57
GLN A 214
LEU A  47
VAL A  49
ILE A  30
None
NRQ  A  67 ( 4.5A)
None
None
None
1.24A 4k38B-5lk4A:
undetectable
4k38B-5lk4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
4i2y RGECO1
(Gallus
gallus;
Rattus
norvegicus;
Discosoma
sp.)
4 / 4 ILE A 112
SER A  62
ASP A 115
ASP A 363
NRQ  A 224 ( 3.9A)
NRQ  A 224 ( 4.5A)
None
CA  A 501 (-3.0A)
1.31A 4krhB-4i2yA:
undetectable
4krhB-4i2yA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata;
Anemonia
sulcata)
4 / 5 GLY L  37
ALA A 216
PHE A  69
GLU A 214
None
None
None
NRQ  A  65 ( 3.1A)
0.89A 4m93B-3cfhL:
undetectable
4m93C-3cfhL:
undetectable
4m93B-3cfhL:
15.42
4m93C-3cfhL:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor)
4 / 5 GLY A 107
ALA A  50
PHE A 139
GLU A  48
None
None
None
NRQ  A 133 ( 3.9A)
1.06A 4m93B-3rwaA:
undetectable
4m93C-3rwaA:
undetectable
4m93B-3rwaA:
19.44
4m93C-3rwaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)
3u0n MRUBY
(Entacmaea
quadricolor)
4 / 5 GLY A  37
ALA A 217
PHE A  69
GLU A 215
None
None
None
NRQ  A  64 ( 3.0A)
1.05A 4m93B-3u0nA:
undetectable
4m93C-3u0nA:
undetectable
4m93B-3u0nA:
20.59
4m93C-3u0nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)
5ukg K-GECO
(Entacmaea
quadricolor)
4 / 5 GLY A 159
ALA A 106
PHE A 191
GLU A 104
None
None
None
NRQ  A 186 ( 3.6A)
0.97A 4m93B-5ukgA:
undetectable
4m93C-5ukgA:
undetectable
4m93B-5ukgA:
undetectable
4m93C-5ukgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli)
5 / 10 LEU A  62
LEU A 203
ILE A  47
LEU A  19
PHE A  59
None
NRQ  A  67 ( 4.2A)
None
None
None
1.07A 4odoA-5bqlA:
undetectable
4odoA-5bqlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor)
3 / 3 ASN A 143
SER A 158
ARG A  92
NRQ  A  63 ( 3.1A)
NRQ  A  63 ( 2.4A)
NRQ  A  63 ( 3.1A)
0.94A 5b2qA-1uisA:
undetectable
5b2qA-1uisA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli)
3 / 3 TYR A 121
TYR A  83
SER A  87
NRQ  A  67 ( 4.5A)
None
None
1.00A 5iktB-5bqlA:
undetectable
5iktB-5bqlA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5lk4 MSCARLET
(Discosoma
sp.)
3 / 3 TYR A 121
TYR A  83
SER A  87
NRQ  A  67 ( 4.5A)
None
None
0.99A 5iktB-5lk4A:
undetectable
5iktB-5lk4A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor)
4 / 4 LEU A  58
ARG A  92
ILE A  57
PHE A 102
None
NRQ  A  63 ( 3.1A)
None
None
1.33A 5kirB-1uisA:
undetectable
5kirB-1uisA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata)
4 / 5 TYR A  72
GLU A 195
TYR A 213
HIS A 197
None
None
None
NRQ  A  65 ( 3.8A)
1.29A 6ep4A-3cfhA:
undetectable
6ep4A-3cfhA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)
1uis RED FLUORESCENT
PROTEIN FP611

(Entacmaea
quadricolor)
5 / 11 ILE A  70
TYR A 178
LEU A 154
GLY A 156
SER A 158
ACY  A1001 (-4.8A)
None
None
None
NRQ  A  63 ( 2.4A)
1.05A 6ieyA-1uisA:
undetectable
6ieyB-1uisA:
undetectable
6ieyA-1uisA:
21.34
6ieyB-1uisA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata)
5 / 11 ILE A  70
TYR A 178
LEU A 154
GLY A 156
SER A 158
None
None
None
None
NRQ  A  65 ( 2.0A)
1.19A 6ieyA-3cfhA:
undetectable
6ieyB-3cfhA:
undetectable
6ieyA-3cfhA:
19.38
6ieyB-3cfhA:
19.38