SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NRF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_B_115B1_1 (HMG-COA REDUCTASE)	5mog	PHYTOENE DEHYDROGENASE, CHLOROPLASTIC/CHROMO PLASTIC (Oryza sativa)	5 / 9	GLU A 513 CYH A 512 LEU A 538 LEU A 281 LEU A 289	None None NRF A 601 ( 4.5A) NRF A 601 (-4.6A) None	1.35A	1hwiA-5mogA: 2.6	1hwiA-5mogA: 23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_A_X2NA1480_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	5mog	PHYTOENE DEHYDROGENASE, CHLOROPLASTIC/CHROMO PLASTIC (Oryza sativa)	5 / 12	MET A 188 PHE A 190 ALA A 276 ALA A 280 MET A 310	NRF A 601 ( 4.2A) None None NRF A 601 (-3.4A) NRF A 601 ( 4.6A)	1.30A	2x2nA-5mogA: undetectable	2x2nA-5mogA: 24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_C_X2NC1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	5mog	PHYTOENE DEHYDROGENASE, CHLOROPLASTIC/CHROMO PLASTIC (Oryza sativa)	5 / 12	MET A 188 PHE A 190 ALA A 276 ALA A 280 MET A 310	NRF A 601 ( 4.2A) None None NRF A 601 (-3.4A) NRF A 601 ( 4.6A)	1.34A	2x2nC-5mogA: undetectable	2x2nC-5mogA: 24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L4D_B_TPFB490_1 (STEROL 14-ALPHA DEMETHYLASE)	5mog	PHYTOENE DEHYDROGENASE, CHLOROPLASTIC/CHROMO PLASTIC (Oryza sativa)	5 / 9	MET A 188 PHE A 190 ALA A 276 ALA A 280 MET A 310	NRF A 601 ( 4.2A) None None NRF A 601 (-3.4A) NRF A 601 ( 4.6A)	1.28A	3l4dB-5mogA: undetectable	3l4dB-5mogA: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L4D_C_TPFC490_1 (STEROL 14-ALPHA DEMETHYLASE)	5mog	PHYTOENE DEHYDROGENASE, CHLOROPLASTIC/CHROMO PLASTIC (Oryza sativa)	5 / 9	MET A 188 PHE A 190 ALA A 276 ALA A 280 MET A 310	NRF A 601 ( 4.2A) None None NRF A 601 (-3.4A) NRF A 601 ( 4.6A)	1.25A	3l4dC-5mogA: undetectable	3l4dC-5mogA: 23.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWI_B_115B1_1","HMG-COA REDUCTASE;HMG-COA REDUCTASE","5mog","PHYTOENE DEHYDROGENASE, CHLOROPLASTIC\/CHROMOPLASTIC","Oryza sativa",5,"GLU A 513;CYH A 512;LEU A 538;LEU A 281;LEU A 289","None;None;NRF A 601 ( 4.5A);NRF A 601 (-4.6A);None","1.35A","1hwiA-5mogA:2.6",null],["2X2N_A_X2NA1480_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","5mog","PHYTOENE DEHYDROGENASE, CHLOROPLASTIC\/CHROMOPLASTIC","Oryza sativa",5,"MET A 188;PHE A 190;ALA A 276;ALA A 280;MET A 310","NRF A 601 ( 4.2A);None;None;NRF A 601 (-3.4A);NRF A 601 ( 4.6A)","1.30A","2x2nA-5mogA:undetectable","1hwiA-5mogA:23.90"],["2X2N_C_X2NC1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","5mog","PHYTOENE DEHYDROGENASE, CHLOROPLASTIC\/CHROMOPLASTIC","Oryza sativa",5,"MET A 188;PHE A 190;ALA A 276;ALA A 280;MET A 310","NRF A 601 ( 4.2A);None;None;NRF A 601 (-3.4A);NRF A 601 ( 4.6A)","1.34A","2x2nC-5mogA:undetectable","2x2nA-5mogA:24.08"],["3L4D_B_TPFB490_1","STEROL 14-ALPHA DEMETHYLASE","5mog","PHYTOENE DEHYDROGENASE, CHLOROPLASTIC\/CHROMOPLASTIC","Oryza sativa",5,"MET A 188;PHE A 190;ALA A 276;ALA A 280;MET A 310","NRF A 601 ( 4.2A);None;None;NRF A 601 (-3.4A);NRF A 601 ( 4.6A)","1.28A","3l4dB-5mogA:undetectable","2x2nC-5mogA:24.08"],["3L4D_C_TPFC490_1","STEROL 14-ALPHA DEMETHYLASE","5mog","PHYTOENE DEHYDROGENASE, CHLOROPLASTIC\/CHROMOPLASTIC","Oryza sativa",5,"MET A 188;PHE A 190;ALA A 276;ALA A 280;MET A 310","NRF A 601 ( 4.2A);None;None;NRF A 601 (-3.4A);NRF A 601 ( 4.6A)","1.25A","3l4dC-5mogA:undetectable","3l4dB-5mogA:23.91"]]