SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NPQ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	5fjp	O-SUCCINYLBENZOATE SYNTHASE (Amycolatopsis sp.)	5 / 11	GLY A 293 GLU A 46 GLY A 296 ASP A 327 ILE A 328	NPQ A1369 ( 4.1A) None None None None	1.01A	2x1lA-5fjpA: undetectable	2x1lA-5fjpA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	5fjp	O-SUCCINYLBENZOATE SYNTHASE (Amycolatopsis sp.)	5 / 12	GLY A 293 GLU A 46 GLY A 296 ASP A 327 ILE A 328	NPQ A1369 ( 4.1A) None None None None	1.02A	2x1lB-5fjpA: undetectable	2x1lB-5fjpA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	5fjp	O-SUCCINYLBENZOATE SYNTHASE (Amycolatopsis sp.)	5 / 11	GLY A 293 GLU A 46 GLY A 296 ASP A 327 ILE A 328	NPQ A1369 ( 4.1A) None None None None	1.03A	2x1lC-5fjpA: undetectable	2x1lC-5fjpA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E2I_A_DMEA605_1 (ACETYLCHOLINESTERASE)	5fjp	O-SUCCINYLBENZOATE SYNTHASE (Amycolatopsis sp.)	4 / 6	TYR A 157 TYR A 152 PHE A 19 TYR A 323	None None NPQ A1369 (-3.8A) NPQ A1369 (-4.3A)	1.08A	5e2iA-5fjpA: 1.5	5e2iA-5fjpA: 21.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2X1L_A_ADNA601_1","METHIONYL-TRNA SYNTHETASE","5fjp","O-SUCCINYLBENZOATE SYNTHASE","Amycolatopsis sp.",5,"GLY A 293;GLU A  46;GLY A 296;ASP A 327;ILE A 328","NPQ A1369 ( 4.1A);None;None;None;None","1.01A","2x1lA-5fjpA:undetectable",null],["2X1L_B_ADNB601_1","METHIONYL-TRNA SYNTHETASE","5fjp","O-SUCCINYLBENZOATE SYNTHASE","Amycolatopsis sp.",5,"GLY A 293;GLU A  46;GLY A 296;ASP A 327;ILE A 328","NPQ A1369 ( 4.1A);None;None;None;None","1.02A","2x1lB-5fjpA:undetectable","2x1lA-5fjpA:22.51"],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","5fjp","O-SUCCINYLBENZOATE SYNTHASE","Amycolatopsis sp.",5,"GLY A 293;GLU A  46;GLY A 296;ASP A 327;ILE A 328","NPQ A1369 ( 4.1A);None;None;None;None","1.03A","2x1lC-5fjpA:undetectable","2x1lB-5fjpA:22.51"],["5E2I_A_DMEA605_1","ACETYLCHOLINESTERASE","5fjp","O-SUCCINYLBENZOATE SYNTHASE","Amycolatopsis sp.",4,"TYR A 157;TYR A 152;PHE A  19;TYR A 323","None;None;NPQ A1369 (-3.8A);NPQ A1369 (-4.3A)","1.08A","5e2iA-5fjpA:1.5","2x1lC-5fjpA:22.51"]]