SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NPO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
ALA X 146
HIS X 149
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
NPO  X1601 (-4.0A)
 1.48A 2a3rA-2zyvX:
45.5		 2a3rA-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.36A 2a3rA-2zyvX:
45.5		 2a3rA-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		6 / 9 PHE A  24
PRO A  47
PHE A  81
LYS A 106
HIS A 108
HIS A 149
 None
None
NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.6A)
 0.41A 2a3rA-3qvuA:
48.8		 2a3rA-3qvuA:
91.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		5 / 9 PHE A  81
LYS A 106
HIS A 108
ALA A 146
HIS A 149
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.6A)
 1.45A 2a3rA-3qvuA:
48.8		 2a3rA-3qvuA:
91.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
ALA X 146
HIS X 149
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
NPO  X1601 (-4.0A)
 1.46A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.34A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		6 / 9 PHE A  24
PRO A  47
PHE A  81
LYS A 106
HIS A 108
HIS A 149
 None
None
NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.6A)
 0.39A 2a3rB-3qvuA:
48.8		 2a3rB-3qvuA:
91.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		5 / 9 PHE A  81
LYS A 106
HIS A 108
ALA A 146
HIS A 149
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.6A)
 1.44A 2a3rB-3qvuA:
48.8		 2a3rB-3qvuA:
91.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
MET X 145
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
None
 0.94A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.02A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
PHE X 142
PHE X   8
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.30A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PRO X  47
LYS X  48
HIS X 108
PHE X 142
ALA X 146
PHE X   8
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 1.27A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PRO X  47
LYS X  48
LYS X 106
HIS X 108
ALA X 146
MET X 145
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
None
 1.48A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		7 / 10 PRO X  47
LYS X  48
LYS X 106
HIS X 108
PHE X 142
ALA X 146
MET X 248
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 0.39A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		8 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 106
HIS A 108
ALA A 146
VAL A 148
MET A 145
 None
None
A3P  A2001 (-3.1A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
None
 1.34A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		9 / 10 PHE A  24
PRO A  47
LYS A  48
LYS A 106
HIS A 108
PHE A 142
ALA A 146
VAL A 148
MET A 248
 None
None
A3P  A2001 (-3.1A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
NPO  A 296 ( 4.3A)
 0.42A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		5 / 10 PHE A  84
LYS A  48
ALA A 146
VAL A 148
MET A 145
 None
A3P  A2001 (-3.1A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
None
 1.33A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		5 / 10 PHE A  84
LYS A  48
PHE A 142
ALA A 146
VAL A 148
 None
A3P  A2001 (-3.1A)
NPO  A 296 (-4.8A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
 1.08A 2d06A-3qvuA:
48.8		 2d06A-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE X  21
PRO X  47
HIS X 108
PHE X 142
PHE X   8
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.37A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
HIS X 108
PHE X 142
TYR X 240
MET X 248
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
None
 1.03A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PRO X  47
HIS X 108
PHE X 142
ALA X 146
PHE X   8
 PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 1.32A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		7 / 10 PRO X  47
LYS X 106
HIS X 108
PHE X 142
ALA X 146
TYR X 240
MET X 248
 PPS  X1501 (-4.3A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
None
 0.42A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		7 / 10 PHE A  24
PRO A  47
LYS A 106
HIS A 108
ALA A 146
VAL A 148
MET A 145
 None
None
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
None
 1.43A 2d06B-3qvuA:
48.9		 2d06B-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		9 / 10 PHE A  24
PRO A  47
LYS A 106
HIS A 108
PHE A 142
ALA A 146
VAL A 148
TYR A 240
MET A 248
 None
None
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
NPO  A 296 ( 4.0A)
NPO  A 296 (-4.7A)
None
NPO  A 296 ( 4.3A)
 0.39A 2d06B-3qvuA:
48.9		 2d06B-3qvuA:
97.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 9 PHE X  81
LYS X 106
HIS X 108
ILE X  89
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1602 (-4.2A)
 1.27A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.32A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		4 / 9 PHE A  81
HIS A 108
PHE A 142
ILE A 243
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
None
 0.92A 4jvlA-3qvuA:
43.3		 4jvlA-3qvuA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		6 / 9 PHE A  81
LYS A 106
HIS A 108
PHE A 142
ILE A 247
MET A 248
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
None
NPO  A 296 ( 4.3A)
 0.45A 4jvlA-3qvuA:
43.3		 4jvlA-3qvuA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_B_ESTB302_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.35A 4jvlB-2zyvX:
44.6		 4jvlB-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_B_ESTB302_1
(ESTROGEN
SULFOTRANSFERASE)		 3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens) 		6 / 9 PHE A  81
LYS A 106
HIS A 108
PHE A 142
ILE A 247
MET A 248
 NPO  A 296 ( 4.7A)
NPO  A 296 (-3.0A)
NPO  A 296 (-3.7A)
NPO  A 296 (-4.8A)
None
NPO  A 296 ( 4.3A)
 0.49A 4jvlB-3qvuA:
42.8		 4jvlB-3qvuA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		3 / 3 ILE X  86
PRO X  87
ILE X  89
 None
None
NPO  X1602 (-4.2A)
 0.42A 5hw8F-2zyvX:
undetectable		 5hw8F-2zyvX:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 12 ILE X  24
VAL X  31
ILE X 148
HIS X 108
MET X  95
 None
None
NPO  X1601 (-4.0A)
NPO  X1601 ( 3.7A)
None
 1.45A 6j21A-2zyvX:
undetectable		 6j21A-2zyvX:
19.28