SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NPI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 6 PHE A 170
LEU A 125
PRO A 100
ALA A 106
LEU A 131
 NPI  A 381 (-4.7A)
None
None
None
None
 1.39A 2vcvB-3r5bA:
undetectable		 2vcvB-3r5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		5 / 6 PHE A 170
LEU A 125
PRO A 100
ALA A 106
LEU A 131
 NPI  A 381 (-4.7A)
None
None
None
None
 1.41A 2vcvK-3r5bA:
undetectable		 2vcvK-3r5bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 252
VAL A 228
GLY A 227
GLY A 244
 None
None
None
NPI  A 381 (-3.2A)
 0.79A 2wd9A-3r5bA:
undetectable		 2wd9A-3r5bA:
22.43