SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NPF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PS9_A_SAMA670_0 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	2paf	LACTOSE OPERON REPRESSOR (Escherichia coli)	5 / 12	GLU A 217 GLY A 218 GLY A 187 ASN A 246 MET A 249	None None None NPF A 902 (-3.7A) None	1.21A	3ps9A-2pafA: 4.7	3ps9A-2pafA: 17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTR_A_SAMA301_0 (DNA ADENINE METHYLASE)	2paf	LACTOSE OPERON REPRESSOR (Escherichia coli)	5 / 11	GLY A 103 ASP A 149 ASN A 125 SER A 158 ASP A 129	None NPF A 902 (-3.8A) NPF A 902 (-2.6A) None None	1.48A	4rtrA-2pafA: 4.3	4rtrA-2pafA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2paf	LACTOSE OPERON REPRESSOR (Escherichia coli)	5 / 9	ASP A 247 ASN A 246 SER A 279 SER A 280 THR A 329	None NPF A 902 (-3.7A) None None None	1.21A	6awpA-2pafA: undetectable	6awpA-2pafA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EKU_A_ZMRA901_2 (SIALIDASE)	2paf	LACTOSE OPERON REPRESSOR (Escherichia coli)	4 / 6	ASP A 274 ASN A 125 LEU A 71 SER A 70	NPF A 902 (-2.6A) NPF A 902 (-2.6A) None None	1.11A	6ekuA-2pafA: undetectable	6ekuA-2pafA: 17.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3PS9_A_SAMA670_0","TRNA 5-METHYLAMINOMETHYL-2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC","2paf","LACTOSE OPERON REPRESSOR","Escherichia coli",5,"GLU A 217;GLY A 218;GLY A 187;ASN A 246;MET A 249","None;None;None;NPF A 902 (-3.7A);None","1.21A","3ps9A-2pafA:4.7",null],["4RTR_A_SAMA301_0","DNA ADENINE METHYLASE","2paf","LACTOSE OPERON REPRESSOR","Escherichia coli",5,"GLY A 103;ASP A 149;ASN A 125;SER A 158;ASP A 129","None;NPF A 902 (-3.8A);NPF A 902 (-2.6A);None;None","1.48A","4rtrA-2pafA:4.3","3ps9A-2pafA:17.28"],["6AWP_A_FVXA701_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","2paf","LACTOSE OPERON REPRESSOR","Escherichia coli",5,"ASP A 247;ASN A 246;SER A 279;SER A 280;THR A 329","None;NPF A 902 (-3.7A);None;None;None","1.21A","6awpA-2pafA:undetectable","4rtrA-2pafA:21.97"],["6EKU_A_ZMRA901_2","SIALIDASE","2paf","LACTOSE OPERON REPRESSOR","Escherichia coli",4,"ASP A 274;ASN A 125;LEU A  71;SER A  70","NPF A 902 (-2.6A);NPF A 902 (-2.6A);None;None","1.11A","6ekuA-2pafA:undetectable","6awpA-2pafA:18.46"]]