SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NP6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LH8_A_VIBA1_1 (MAJOR PRION PROTEIN)	3gs6	BETA-HEXOSAMINIDASE (Vibrio cholerae)	4 / 6	PRO A 163 HIS A 161 ASP A 243 ASP A 242	None NP6 A 341 (-3.6A) NP6 A 341 ( 4.6A) None	1.35A	2lh8A-3gs6A: undetectable	2lh8A-3gs6A: 14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C5N_A_PXLA300_1 (PHOSPHOMETHYLPYRIMID INE KINASE)	3gs6	BETA-HEXOSAMINIDASE (Vibrio cholerae)	4 / 7	GLY A 121 ASP A 119 GLY A 166 HIS A 161	None None None NP6 A 341 (-3.6A)	0.93A	4c5nA-3gs6A: 2.3	4c5nA-3gs6A: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEN_A_5OGA804_1 (HDAC6 PROTEIN)	3gs6	BETA-HEXOSAMINIDASE (Vibrio cholerae)	5 / 12	PRO A 177 SER A 219 ASP A 119 HIS A 161 GLY A 166	None None None NP6 A 341 (-3.6A) None	1.28A	5eenA-3gs6A: undetectable	5eenA-3gs6A: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M6G_A_SORA711_0 (BETA-GLUCOSIDASE)	3gs6	BETA-HEXOSAMINIDASE (Vibrio cholerae)	5 / 12	ASP A 62 PHE A 114 LYS A 160 HIS A 161 MET A 204	NP6 A 341 (-3.0A) None NP6 A 341 (-3.0A) NP6 A 341 (-3.6A) NP6 A 341 (-3.5A)	0.52A	5m6gA-3gs6A: 24.8	5m6gA-3gs6A: 20.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2LH8_A_VIBA1_1","MAJOR PRION PROTEIN","3gs6","BETA-HEXOSAMINIDASE","Vibrio cholerae",4,"PRO A 163;HIS A 161;ASP A 243;ASP A 242","None;NP6 A 341 (-3.6A);NP6 A 341 ( 4.6A);None","1.35A","2lh8A-3gs6A:undetectable",null],["4C5N_A_PXLA300_1","PHOSPHOMETHYLPYRIMIDINE KINASE","3gs6","BETA-HEXOSAMINIDASE","Vibrio cholerae",4,"GLY A 121;ASP A 119;GLY A 166;HIS A 161","None;None;None;NP6 A 341 (-3.6A)","0.93A","4c5nA-3gs6A:2.3","2lh8A-3gs6A:14.37"],["5EEN_A_5OGA804_1","HDAC6 PROTEIN","3gs6","BETA-HEXOSAMINIDASE","Vibrio cholerae",5,"PRO A 177;SER A 219;ASP A 119;HIS A 161;GLY A 166","None;None;None;NP6 A 341 (-3.6A);None","1.28A","5eenA-3gs6A:undetectable","4c5nA-3gs6A:21.57"],["5M6G_A_SORA711_0","BETA-GLUCOSIDASE","3gs6","BETA-HEXOSAMINIDASE","Vibrio cholerae",5,"ASP A  62;PHE A 114;LYS A 160;HIS A 161;MET A 204","NP6 A 341 (-3.0A);None;NP6 A 341 (-3.0A);NP6 A 341 (-3.6A);NP6 A 341 (-3.5A)","0.52A","5m6gA-3gs6A:24.8","5eenA-3gs6A:19.95"]]