SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NOS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 HIS A  70
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 None
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.38A 1a4lA-4f0sA:
21.5		 1a4lA-4f0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 HIS A  72
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.51A 1a4lA-4f0sA:
21.5		 1a4lA-4f0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  91
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 ( 4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.57A 1a4lB-4f0sA:
21.5		 1a4lB-4f0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  70
HIS A  72
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 None
NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.47A 1a4lC-4f0sA:
21.5		 1a4lC-4f0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 HIS A  72
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.46A 1a4lD-4f0sA:
21.4		 1a4lD-4f0sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 5 THR A 196
GLU A 226
THR A 223
LEU A  91
 None
None
None
NOS  A 501 ( 4.8A)
 1.15A 1d4fC-4f0sA:
undetectable		 1d4fC-4f0sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 HIS A 192
HIS A 219
HIS A  70
ASN A 278
ASP A 307
 NOS  A 501 (-4.0A)
NOS  A 501 (-3.5A)
None
None
NOS  A 501 (-2.8A)
 1.29A 1ituA-4f0sA:
5.3		 1ituA-4f0sA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 10 ARG A  88
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.44A 1jdvA-2bsxA:
31.9
1jdvD-2bsxA:
31.9		 1jdvA-2bsxA:
29.30
1jdvD-2bsxA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 10 ARG A  88
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.42A 1jdvB-2bsxA:
32.0
1jdvC-2bsxA:
31.8		 1jdvB-2bsxA:
29.30
1jdvC-2bsxA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 10 ARG A  88
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.44A 1jdvA-2bsxA:
31.9
1jdvD-2bsxA:
31.9		 1jdvA-2bsxA:
29.30
1jdvD-2bsxA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 12 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.41A 1jdvE-2bsxA:
31.9
1jdvF-2bsxA:
31.8		 1jdvE-2bsxA:
29.30
1jdvF-2bsxA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 TRP A  96
GLU A  99
HIS A 219
ILE A  95
LEU A  91
 NOS  A 501 ( 4.4A)
NOS  A 501 ( 2.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.2A)
NOS  A 501 ( 4.8A)
 1.14A 1kyvA-4f0sA:
undetectable
1kyvE-4f0sA:
undetectable		 1kyvA-4f0sA:
16.29
1kyvE-4f0sA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 ILE A  95
LEU A  91
TRP A  96
GLU A  99
HIS A 219
 NOS  A 501 (-4.2A)
NOS  A 501 ( 4.8A)
NOS  A 501 ( 4.4A)
NOS  A 501 ( 2.8A)
NOS  A 501 (-3.5A)
 1.14A 1kyvB-4f0sA:
undetectable
1kyvC-4f0sA:
undetectable		 1kyvB-4f0sA:
16.29
1kyvC-4f0sA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 11 ARG A  88
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.56A 1odiA-2bsxA:
25.0		 1odiA-2bsxA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 11 ARG A  88
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.53A 1odiB-2bsxA:
32.9		 1odiB-2bsxA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 11 ARG A  88
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.57A 1odiC-2bsxA:
33.4		 1odiC-2bsxA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 11 ARG A  88
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.55A 1odiD-2bsxA:
33.3		 1odiD-2bsxA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 11 ARG A  88
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.53A 1odiE-2bsxA:
33.4		 1odiE-2bsxA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 11 ARG A  88
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.57A 1odiF-2bsxA:
33.3		 1odiF-2bsxA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 9 ARG A  88
SER A  91
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.54A 1pk7A-2bsxA:
32.0		 1pk7A-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 8 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.48A 1pk7B-2bsxA:
32.3		 1pk7B-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 10 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.53A 1pk7C-2bsxA:
32.0		 1pk7C-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 10 GLY A  93
VAL A 181
GLU A 182
MET A 183
ASP A 206
 NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-4.1A)
 1.35A 1pk7C-2bsxA:
32.0		 1pk7C-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 10 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.52A 1pk9A-2bsxA:
31.9		 1pk9A-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 9 ARG A  88
SER A  91
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.49A 1pk9B-2bsxA:
32.2		 1pk9B-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.51A 1pk9C-2bsxA:
30.8		 1pk9C-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 ARG A  88
SER A  91
GLY A  93
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.53A 1pw7A-2bsxA:
31.9		 1pw7A-2bsxA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 9 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.53A 1pw7B-2bsxA:
32.2		 1pw7B-2bsxA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 9 SER A  91
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 (-2.9A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.42A 1pw7C-2bsxA:
32.1		 1pw7C-2bsxA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.64A 1vhwA-2bsxA:
32.4
1vhwD-2bsxA:
32.5		 1vhwA-2bsxA:
29.17
1vhwD-2bsxA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 9 ARG A  88
SER A  91
GLY A  93
VAL A 181
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.64A 1vhwB-2bsxA:
32.0
1vhwF-2bsxA:
32.2		 1vhwB-2bsxA:
29.17
1vhwF-2bsxA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.63A 1vhwC-2bsxA:
32.6
1vhwE-2bsxA:
32.3		 1vhwC-2bsxA:
29.17
1vhwE-2bsxA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.62A 1vhwA-2bsxA:
32.4
1vhwD-2bsxA:
32.5		 1vhwA-2bsxA:
29.17
1vhwD-2bsxA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.63A 1vhwC-2bsxA:
32.6
1vhwE-2bsxA:
32.3		 1vhwC-2bsxA:
29.17
1vhwE-2bsxA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 10 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.64A 1vhwB-2bsxA:
32.0
1vhwF-2bsxA:
32.2		 1vhwB-2bsxA:
29.17
1vhwF-2bsxA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.63A 1z35A-2bsxA:
33.2		 1z35A-2bsxA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 9 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.59A 1z37A-2bsxA:
33.3		 1z37A-2bsxA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 ILE A  95
LEU A  91
TRP A  96
GLU A  99
HIS A 219
 NOS  A 501 (-4.2A)
NOS  A 501 ( 4.8A)
NOS  A 501 ( 4.4A)
NOS  A 501 ( 2.8A)
NOS  A 501 (-3.5A)
 1.11A 2a58A-4f0sA:
undetectable
2a58B-4f0sA:
undetectable		 2a58A-4f0sA:
16.29
2a58B-4f0sA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 ILE A  95
LEU A  91
TRP A  96
GLU A  99
HIS A 219
 NOS  A 501 (-4.2A)
NOS  A 501 ( 4.8A)
NOS  A 501 ( 4.4A)
NOS  A 501 ( 2.8A)
NOS  A 501 (-3.5A)
 1.11A 2a58B-4f0sA:
undetectable
2a58C-4f0sA:
undetectable		 2a58B-4f0sA:
16.29
2a58C-4f0sA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 ILE A  95
LEU A  91
TRP A  96
GLU A  99
HIS A 219
 NOS  A 501 (-4.2A)
NOS  A 501 ( 4.8A)
NOS  A 501 ( 4.4A)
NOS  A 501 ( 2.8A)
NOS  A 501 (-3.5A)
 1.11A 2a58D-4f0sA:
undetectable
2a58E-4f0sA:
undetectable		 2a58D-4f0sA:
16.29
2a58E-4f0sA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 11 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.56A 2ac7A-2bsxA:
31.7
2ac7B-2bsxA:
31.8		 2ac7A-2bsxA:
29.71
2ac7B-2bsxA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 11 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.56A 2ac7A-2bsxA:
31.7
2ac7B-2bsxA:
31.8		 2ac7A-2bsxA:
29.71
2ac7B-2bsxA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 4 LEU A  91
SER A 287
ASP A 307
ASP A 129
 NOS  A 501 ( 4.8A)
None
NOS  A 501 (-2.8A)
None
 1.23A 2br4B-4f0sA:
undetectable		 2br4B-4f0sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 11 LEU A 285
HIS A 219
HIS A  72
THR A 306
GLU A 320
 None
NOS  A 501 (-3.5A)
NOS  A 501 (-3.7A)
None
None
 1.33A 2dttD-4f0sA:
undetectable
2dttE-4f0sA:
undetectable		 2dttD-4f0sA:
15.65
2dttE-4f0sA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 9 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.04A 2jihA-4f0sA:
undetectable		 2jihA-4f0sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 8 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.04A 2jihB-4f0sA:
undetectable		 2jihB-4f0sA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 285
HIS A  70
HIS A  72
HIS A 219
 None
None
NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
 0.86A 2ow9A-4f0sA:
undetectable		 2ow9A-4f0sA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  70
HIS A  72
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 None
NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.35A 2pgrA-4f0sA:
22.8		 2pgrA-4f0sA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 8 ASP A 307
HIS A 256
SER A 287
LEU A 285
 NOS  A 501 (-2.8A)
NOS  A 501 (-4.0A)
None
None
 0.93A 2q0iA-4f0sA:
undetectable		 2q0iA-4f0sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 11 ASP A 307
HIS A  70
HIS A 256
SER A 287
LEU A 285
 NOS  A 501 (-2.8A)
None
NOS  A 501 (-4.0A)
None
None
 1.07A 2q0jB-4f0sA:
undetectable		 2q0jB-4f0sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A  70
HIS A 256
HIS A 219
 None
NOS  A 501 (-4.0A)
NOS  A 501 (-3.5A)
 0.70A 2w0qA-4f0sA:
undetectable		 2w0qA-4f0sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A  70
HIS A 256
HIS A 219
 None
NOS  A 501 (-4.0A)
NOS  A 501 (-3.5A)
 0.70A 2w0qB-4f0sA:
undetectable		 2w0qB-4f0sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.77A 2zxwA-4f0sA:
undetectable		 2zxwA-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.75A 3abkA-4f0sA:
undetectable		 3abkA-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.74A 3ag2A-4f0sA:
undetectable		 3ag2A-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A  70
HIS A 256
HIS A 219
 None
NOS  A 501 (-4.0A)
NOS  A 501 (-3.5A)
 0.71A 3hiiA-4f0sA:
undetectable		 3hiiA-4f0sA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A  70
HIS A 256
HIS A 219
 None
NOS  A 501 (-4.0A)
NOS  A 501 (-3.5A)
 0.69A 3hiiB-4f0sA:
undetectable		 3hiiB-4f0sA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 9 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.14A 3hy7A-4f0sA:
undetectable		 3hy7A-4f0sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 9 ASP A  89
THR A 223
GLU A 222
HIS A 219
HIS A 192
 None
None
NOS  A 501 (-3.0A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
 1.23A 3hy7B-4f0sA:
undetectable		 3hy7B-4f0sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 11 HIS A  70
ASN A 282
LEU A  87
LEU A 242
THR A 223
 None
None
NOS  A 501 (-4.8A)
None
None
 1.35A 3jwqB-4f0sA:
undetectable
3jwqC-4f0sA:
undetectable		 3jwqB-4f0sA:
21.12
3jwqC-4f0sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 5 LEU A 285
HIS A  70
HIS A  72
HIS A 219
 None
None
NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
 0.91A 3kecA-4f0sA:
undetectable		 3kecA-4f0sA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 9 ARG A  88
SER A  91
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.74A 3u40A-2bsxA:
31.4
3u40F-2bsxA:
31.9		 3u40A-2bsxA:
28.29
3u40F-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 ARG A  88
SER A  91
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.67A 3u40B-2bsxA:
31.1
3u40C-2bsxA:
31.9		 3u40B-2bsxA:
28.29
3u40C-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 12 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.56A 3u40B-2bsxA:
31.1
3u40C-2bsxA:
31.9		 3u40B-2bsxA:
28.29
3u40C-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.55A 3u40D-2bsxA:
31.4
3u40E-2bsxA:
31.2		 3u40D-2bsxA:
28.29
3u40E-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 12 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.51A 3u40D-2bsxA:
31.4
3u40E-2bsxA:
31.2		 3u40D-2bsxA:
28.29
3u40E-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 ARG A  88
SER A  91
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.75A 3u40A-2bsxA:
31.4
3u40F-2bsxA:
31.9		 3u40A-2bsxA:
28.29
3u40F-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 10 VAL A 181
GLU A 182
MET A 183
GLU A 184
ASP A 206
 NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
NOS  A1248 (-4.1A)
 1.09A 3u40A-2bsxA:
31.4
3u40F-2bsxA:
31.9		 3u40A-2bsxA:
28.29
3u40F-2bsxA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 11 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.57A 3uawA-2bsxA:
32.3		 3uawA-2bsxA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.55A 3uayA-2bsxA:
32.3		 3uayA-2bsxA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 9 ALA A 301
ARG A 353
GLY A 351
LEU A 355
ASN A 128
 None
NOS  A 502 (-4.4A)
None
None
None
 1.17A 3wdmA-4f0sA:
undetectable		 3wdmA-4f0sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 9 ALA A 309
ARG A  79
GLY A  80
LEU A  81
ILE A  95
 None
None
None
None
NOS  A 501 (-4.2A)
 1.46A 3wdmA-4f0sA:
undetectable		 3wdmA-4f0sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 10 ALA A 301
ARG A 353
GLY A 351
LEU A 355
ASN A 128
 None
NOS  A 502 (-4.4A)
None
None
None
 1.15A 3wdmD-4f0sA:
undetectable		 3wdmD-4f0sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 285
HIS A  70
HIS A  72
HIS A 219
 None
None
NOS  A 501 (-3.7A)
NOS  A 501 (-3.5A)
 0.87A 4a7bA-4f0sA:
undetectable		 4a7bA-4f0sA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		7 / 12 LEU A  87
LEU A  91
HIS A 219
GLU A 222
GLU A 226
HIS A 256
ASP A 307
 NOS  A 501 (-4.8A)
NOS  A 501 ( 4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
None
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.78A 4aqlA-4f0sA:
46.9		 4aqlA-4f0sA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 LEU A  91
HIS A 219
GLU A 222
HIS A 256
SER A 281
ASP A 307
 NOS  A 501 ( 4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
None
NOS  A 501 (-2.8A)
 0.64A 4aqlA-4f0sA:
46.9		 4aqlA-4f0sA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.55A 4d9hA-2bsxA:
31.7		 4d9hA-2bsxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 9 SER A  91
GLY A  93
VAL A 181
MET A 183
GLU A 184
 NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.48A 4da6A-2bsxA:
31.2		 4da6A-2bsxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.55A 4da7A-2bsxA:
31.3		 4da7A-2bsxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 11 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.53A 4danA-2bsxA:
31.3		 4danA-2bsxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		7 / 12 ARG A  88
SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.59A 4danA-2bsxA:
31.3
4danB-2bsxA:
31.4		 4danA-2bsxA:
23.81
4danB-2bsxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  87
HIS A 219
HIS A 256
LEU A 285
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.0A)
None
NOS  A 501 (-2.8A)
 0.60A 4r88A-4f0sA:
34.9		 4r88A-4f0sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  87
HIS A 219
GLU A 222
LEU A 285
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
None
NOS  A 501 (-2.8A)
 0.60A 4r88B-4f0sA:
35.7		 4r88B-4f0sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  87
HIS A 219
GLU A 222
LEU A 285
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
None
NOS  A 501 (-2.8A)
 0.62A 4r88C-4f0sA:
35.0		 4r88C-4f0sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  87
HIS A 219
GLU A 222
LEU A 285
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
None
NOS  A 501 (-2.8A)
 0.60A 4r88D-4f0sA:
35.0		 4r88D-4f0sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  87
HIS A 219
GLU A 222
LEU A 285
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
None
NOS  A 501 (-2.8A)
 0.61A 4r88E-4f0sA:
34.8		 4r88E-4f0sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		6 / 12 HIS A  72
LEU A  87
HIS A 219
GLU A 222
LEU A 285
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
None
NOS  A 501 (-2.8A)
 0.62A 4r88F-4f0sA:
35.1		 4r88F-4f0sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.74A 5b3sA-4f0sA:
undetectable		 5b3sA-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.75A 5b3sN-4f0sA:
undetectable		 5b3sN-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 9 ARG A  88
SER A  91
GLY A  93
VAL A 181
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.54A 5i3cA-2bsxA:
32.4		 5i3cA-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 10 SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.42A 5i3cB-2bsxA:
32.3		 5i3cB-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		6 / 11 SER A  91
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.41A 5i3cC-2bsxA:
32.1		 5i3cC-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 4 HIS A  72
HIS A 256
HIS A 219
HIS A  70
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.0A)
NOS  A 501 (-3.5A)
None
 1.02A 5mhwA-4f0sA:
undetectable		 5mhwA-4f0sA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 6 HIS A  72
HIS A  70
LEU A  91
HIS A 192
 NOS  A 501 (-3.7A)
None
NOS  A 501 ( 4.8A)
NOS  A 501 (-4.0A)
 0.95A 5nelB-4f0sA:
4.7
5nelC-4f0sA:
5.2		 5nelB-4f0sA:
19.59
5nelC-4f0sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.73A 5x19A-4f0sA:
undetectable		 5x19A-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.72A 5x1bA-4f0sA:
undetectable		 5x1bA-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 GLU A  99
TRP A  90
HIS A  72
 NOS  A 501 ( 2.8A)
None
NOS  A 501 (-3.7A)
 1.01A 5xipA-4f0sA:
undetectable		 5xipA-4f0sA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 GLU A 222
TRP A  90
HIS A 192
 NOS  A 501 (-3.0A)
None
NOS  A 501 (-4.0A)
 0.94A 5xipA-4f0sA:
undetectable		 5xipA-4f0sA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		5 / 9 VAL A  66
GLY A  93
VAL A 181
GLU A 182
ASP A 206
 NOS  A1248 ( 3.8A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-4.1A)
 1.43A 5zncA-2bsxA:
42.8		 5zncA-2bsxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		8 / 9 VAL A  66
SER A  91
GLY A  93
TYR A 160
VAL A 181
GLU A 182
MET A 183
TRP A 212
 NOS  A1248 ( 3.8A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 (-4.7A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-4.6A)
 0.31A 5zncA-2bsxA:
42.8		 5zncA-2bsxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE
(Plasmodium
falciparum) 		8 / 9 VAL A  66
GLY A  93
TYR A 160
VAL A 181
GLU A 182
MET A 183
GLY A 207
PRO A 209
 NOS  A1248 ( 3.8A)
NOS  A1248 (-4.0A)
NOS  A1248 (-4.7A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
None
NOS  A1248 ( 4.1A)
 0.46A 5zniA-2bsxA:
42.1		 5zniA-2bsxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		4 / 7 GLY A 356
HIS A 217
ASN A 128
GLY A 303
 NOS  A 502 (-3.6A)
None
None
None
 0.89A 6n7fA-4f0sA:
undetectable		 6n7fA-4f0sA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		7 / 12 HIS A  72
LEU A  87
LEU A  91
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 ( 4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.67A 6n91A-4f0sA:
22.8		 6n91A-4f0sA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 LEU A  87
LEU A  91
ALA A 193
GLU A 222
HIS A 256
 NOS  A 501 (-4.8A)
NOS  A 501 ( 4.8A)
None
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
 0.92A 6n91A-4f0sA:
22.8		 6n91A-4f0sA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		7 / 12 HIS A  72
LEU A  87
LEU A  91
HIS A 219
GLU A 222
HIS A 256
ASP A 307
 NOS  A 501 (-3.7A)
NOS  A 501 (-4.8A)
NOS  A 501 ( 4.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
NOS  A 501 (-2.8A)
 0.76A 6n91B-4f0sA:
22.9		 6n91B-4f0sA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		5 / 12 LEU A  87
LEU A  91
ALA A 193
GLU A 222
HIS A 256
 NOS  A 501 (-4.8A)
NOS  A 501 ( 4.8A)
None
NOS  A 501 (-3.0A)
NOS  A 501 (-4.0A)
 0.91A 6n91B-4f0sA:
22.9		 6n91B-4f0sA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.76A 6nknA-4f0sA:
undetectable		 6nknA-4f0sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE
(Chromobacterium
violaceum) 		3 / 3 HIS A 219
HIS A  70
HIS A 256
 NOS  A 501 (-3.5A)
None
NOS  A 501 (-4.0A)
 0.73A 6nmfA-4f0sA:
undetectable		 6nmfA-4f0sA:
21.89