SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NOJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		6 / 12 TYR A 212
ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 ( 3.9A)
NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.88A 1dedB-2ya2A:
22.4		 1dedB-2ya2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		8 / 12 TYR A 212
HIS A 260
PHE A 288
ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 ( 3.9A)
NOJ  A1689 (-4.5A)
NOJ  A1689 (-3.5A)
NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.83A 1mxdA-2ya2A:
20.2		 1mxdA-2ya2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5ns8 -
(-) 		5 / 12 SER A  15
ILE A  19
LEU A  65
GLY A 412
VAL A 416
 NOJ  A 506 ( 4.0A)
None
SO4  A 502 ( 4.9A)
None
None
 1.14A 1tsnA-5ns8A:
undetectable		 1tsnA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 350
ASP A 255
ASP A 323
GLU A 137
 None
None
NOJ  A1689 (-2.8A)
None
 0.93A 2j2pE-2ya2A:
undetectable
2j2pF-2ya2A:
undetectable		 2j2pE-2ya2A:
14.81
2j2pF-2ya2A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 5ns8 -
(-) 		5 / 11 ASN A 163
GLU A 164
TYR A 291
GLU A 349
TRP A 395
 NOJ  A 506 (-3.1A)
NOJ  A 506 (-2.5A)
NOJ  A 506 (-3.8A)
NOJ  A 506 (-2.6A)
NOJ  A 506 (-3.2A)
 0.82A 2v3dB-5ns8A:
18.1		 2v3dB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.65A 3aicA-2ya2A:
4.7		 3aicA-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.65A 3aicB-2ya2A:
3.4		 3aicB-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
TYR A 212
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
NOJ  A1689 ( 3.9A)
 0.62A 3aicC-2ya2A:
3.8		 3aicC-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.72A 3aicD-2ya2A:
5.5		 3aicD-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.67A 3aicE-2ya2A:
6.2		 3aicE-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.66A 3aicF-2ya2A:
3.8		 3aicF-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.65A 3aicG-2ya2A:
5.8		 3aicG-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.70A 3aicH-2ya2A:
4.0		 3aicH-2ya2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 5 ILE A 333
PHE A 322
ASP A 323
GLU A 352
 None
None
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
 1.18A 3kp6A-2ya2A:
undetectable
3kp6B-2ya2A:
undetectable		 3kp6A-2ya2A:
12.09
3kp6B-2ya2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ns8 -
(-) 		5 / 9 ALA A  73
ASN A 289
ILE A 347
GLU A 349
THR A  14
 None
NOJ  A 506 ( 4.6A)
None
NOJ  A 506 (-2.6A)
None
 1.15A 3rukC-5ns8A:
undetectable		 3rukC-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5ns8 -
(-) 		3 / 3 ASP A 121
TRP A 395
SER A  77
 None
NOJ  A 506 (-3.2A)
None
 1.03A 4lrhB-5ns8A:
undetectable		 4lrhB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A 212
TRP A 210
HIS A 139
PHE A 484
 NOJ  A1689 ( 3.9A)
None
None
None
 1.15A 4tzcB-2ya2A:
undetectable
4tzcD-2ya2A:
undetectable		 4tzcB-2ya2A:
9.43
4tzcD-2ya2A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 321
ASP A 323
GLU A 352
HIS A 439
ASP A 440
 NOJ  A1689 (-3.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.0A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.29A 5csyB-2ya2A:
14.8		 5csyB-2ya2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 212
HIS A 260
ASP A 323
HIS A 439
ASP A 440
 NOJ  A1689 ( 3.9A)
NOJ  A1689 (-4.5A)
NOJ  A1689 (-2.8A)
NOJ  A1689 (-3.8A)
NOJ  A1689 (-2.9A)
 0.52A 6ag0A-2ya2A:
17.2		 6ag0A-2ya2A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 HIS A 533
HIS A 139
ASP A 440
GLU A 352
 None
None
NOJ  A1689 (-2.9A)
NOJ  A1689 (-3.0A)
 1.05A 6mn4C-2ya2A:
undetectable		 6mn4C-2ya2A:
16.13