SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NMN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 11 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.00A 1akdA-1y1pA:
undetectable		 1akdA-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 11 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.04A 1phgA-1y1pA:
undetectable		 1phgA-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 8 THR A 131
LEU A  32
VAL A  28
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
 0.87A 1t86A-1y1pA:
undetectable		 1t86A-1y1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 11 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 0.96A 2a1nA-1y1pA:
undetectable		 2a1nA-1y1pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 10 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.11A 2cp4A-1y1pA:
undetectable		 2cp4A-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 SER A  26
TYR A  29
HIS A  27
 NMN  A 402 (-4.4A)
NMN  A 402 (-3.5A)
None
 0.82A 2r2vD-4lh7A:
undetectable		 2r2vD-4lh7A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		4 / 6 GLU A  30
ALA A 250
LEU A 337
THR A 209
 ACT  A 803 (-4.7A)
None
None
NMN  A1001 (-3.8A)
 1.07A 2roxB-1y1pA:
undetectable		 2roxB-1y1pA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 TYR A  42
ARG A 158
SER A  26
 NMN  A 402 (-3.4A)
NMN  A 402 (-3.7A)
NMN  A 402 (-4.4A)
 0.89A 4khpI-4lh7A:
undetectable
4khpJ-4lh7A:
undetectable		 4khpI-4lh7A:
18.67
4khpJ-4lh7A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		3 / 3 ILE A  91
MET A  72
ARG A  44
 NMN  A1001 (-4.9A)
AMP  A1002 (-3.5A)
AMP  A1002 ( 3.6A)
 0.86A 4lnwA-1y1pA:
undetectable		 4lnwA-1y1pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 9 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
 NMN  A1001 (-4.2A)
None
None
None
None
 1.04A 5cp4A-1y1pA:
undetectable		 5cp4A-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1y1p ALDEHYDE REDUCTASE
II
(Sporidiobolus
salmonicolor) 		5 / 12 LEU A  33
VAL A  17
ILE A  91
ALA A  92
VAL A  28
 None
None
NMN  A1001 (-4.9A)
AMP  A1002 (-3.7A)
None
 0.77A 5j2tC-1y1pA:
5.2		 5j2tC-1y1pA:
21.11