SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NM2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 6 TYR A 327
VAL A 456
ILE A 459
LEU A 483
 NM2  A 601 (-4.4A)
None
None
None
 1.21A 1j96A-4m8jA:
undetectable		 1j96A-4m8jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		5 / 12 PHE A 312
HIS A 141
ILE A 476
GLY A 315
ALA A 322
 None
None
None
NM2  A1505 (-2.5A)
None
 0.93A 3sufB-2wsxA:
undetectable		 3sufB-2wsxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		6 / 12 ALA A 322
ALA A 315
PHE A 319
THR A 206
ILE A 472
TYR A 327
 None
None
None
None
None
NM2  A 601 (-4.4A)
 1.45A 4pssA-4m8jA:
undetectable		 4pssA-4m8jA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.45A 4tzcB-4m8jA:
undetectable
4tzcD-4m8jA:
undetectable		 4tzcB-4m8jA:
11.60
4tzcD-4m8jA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A1504 ( 4.6A)
None
None
 1.42A 4tzuB-2wsxA:
undetectable
4tzuC-2wsxA:
undetectable		 4tzuB-2wsxA:
13.79
4tzuC-2wsxA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.33A 4tzuB-4m8jA:
undetectable
4tzuC-4m8jA:
undetectable		 4tzuB-4m8jA:
11.11
4tzuC-4m8jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A1504 ( 4.6A)
None
 1.42A 4tzuB-2wsxA:
undetectable
4tzuC-2wsxA:
undetectable		 4tzuB-2wsxA:
13.79
4tzuC-2wsxA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.34A 4tzuB-4m8jA:
undetectable
4tzuC-4m8jA:
undetectable		 4tzuB-4m8jA:
11.11
4tzuC-4m8jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 8 ILE A 326
TYR A 327
PHE A 319
LEU A 210
 None
NM2  A1504 (-4.4A)
None
None
 0.88A 5esfA-2wsxA:
undetectable		 5esfA-2wsxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.42A 5yizG-4m8jA:
undetectable
5yizY-4m8jA:
undetectable		 5yizG-4m8jA:
9.07
5yizY-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A1504 ( 4.6A)
None
None
 1.47A 5yizk-2wsxA:
undetectable
5yizt-2wsxA:
undetectable		 5yizk-2wsxA:
9.69
5yizt-2wsxA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.38A 5yizk-4m8jA:
undetectable
5yizt-4m8jA:
undetectable		 5yizk-4m8jA:
9.07
5yizt-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yizk-4m8jA:
undetectable
5yizt-4m8jA:
undetectable		 5yizk-4m8jA:
9.07
5yizt-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A1504 ( 4.6A)
None
 1.49A 5yizG-2wsxA:
undetectable
5yizY-2wsxA:
undetectable		 5yizG-2wsxA:
9.69
5yizY-2wsxA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.40A 5yizG-4m8jA:
undetectable
5yizY-4m8jA:
undetectable		 5yizG-4m8jA:
9.07
5yizY-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.46A 5yj0G-4m8jA:
undetectable
5yj0Y-4m8jA:
undetectable		 5yj0G-4m8jA:
9.07
5yj0Y-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A1504 ( 4.6A)
None
None
 1.49A 5yj0k-2wsxA:
undetectable
5yj0t-2wsxA:
undetectable		 5yj0k-2wsxA:
9.69
5yj0t-2wsxA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.41A 5yj0k-4m8jA:
undetectable
5yj0t-4m8jA:
undetectable		 5yj0k-4m8jA:
9.07
5yj0t-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yj0k-4m8jA:
undetectable
5yj0t-4m8jA:
undetectable		 5yj0k-4m8jA:
9.07
5yj0t-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.42A 5yj0G-4m8jA:
undetectable
5yj0Y-4m8jA:
undetectable		 5yj0G-4m8jA:
9.07
5yj0Y-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.41A 5yj1G-4m8jA:
undetectable
5yj1Y-4m8jA:
undetectable		 5yj1G-4m8jA:
12.10
5yj1Y-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A1504 ( 4.6A)
None
None
 1.49A 5yj1k-2wsxA:
undetectable
5yj1t-2wsxA:
undetectable		 5yj1k-2wsxA:
12.84
5yj1t-2wsxA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.40A 5yj1k-4m8jA:
undetectable
5yj1t-4m8jA:
undetectable		 5yj1k-4m8jA:
12.10
5yj1t-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Escherichia
coli) 		4 / 8 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A1504 ( 4.6A)
None
 1.43A 5yj1k-2wsxA:
undetectable
5yj1t-2wsxA:
undetectable		 5yj1k-2wsxA:
12.84
5yj1t-2wsxA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 8 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.34A 5yj1k-4m8jA:
undetectable
5yj1t-4m8jA:
undetectable		 5yj1k-4m8jA:
12.10
5yj1t-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER
(Proteus
mirabilis) 		4 / 7 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yj1G-4m8jA:
undetectable
5yj1Y-4m8jA:
undetectable		 5yj1G-4m8jA:
12.10
5yj1Y-4m8jA:
12.10