SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NLT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2g0b FEEM
(uncultured
bacterium) 		5 / 10 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.40A 1q6iB-2g0bA:
undetectable		 1q6iB-2g0bA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2g0b FEEM
(uncultured
bacterium) 		4 / 7 VAL A 166
ALA A 170
GLY A 164
THR A 165
 NLT  A 400 (-4.5A)
NLT  A 400 ( 3.7A)
None
None
 0.73A 2xrzB-2g0bA:
undetectable		 2xrzB-2g0bA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2g0b FEEM
(uncultured
bacterium) 		5 / 12 ILE A 141
THR A  61
PHE A 154
ALA A 174
ALA A  93
 NLT  A 400 (-4.9A)
None
NLT  A 400 (-4.7A)
None
None
 1.37A 3ua1A-2g0bA:
undetectable		 3ua1A-2g0bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2g0b FEEM
(uncultured
bacterium) 		5 / 11 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.33A 5hw8B-2g0bA:
undetectable		 5hw8B-2g0bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 2g0b FEEM
(uncultured
bacterium) 		5 / 11 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.31A 5hwcA-2g0bA:
undetectable		 5hwcA-2g0bA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2g0b FEEM
(uncultured
bacterium) 		5 / 10 ASP A  75
ARG A  86
VAL A  96
TYR A 163
ILE A  77
 None
None
NLT  A 400 (-3.4A)
None
None
 1.34A 6mkeC-2g0bA:
undetectable		 6mkeC-2g0bA:
17.28