SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NLP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1YVM_A_TMGA501_1 (METHIONINE AMINOPEPTIDASE)	2gtx	METHIONINE AMINOPEPTIDASE (Escherichia coli)	6 / 7	CYH A 59 TYR A 62 TYR A 65 CYH A 70 HIS A 79 HIS A 178	NLP A3808 ( 3.8A) NLP A3808 ( 4.8A) NLP A3808 ( 4.0A) NLP A3808 ( 3.7A) NLP A3808 (-3.8A) NLP A3808 (-3.9A)	0.60A	1yvmA-2gtxA: 47.9	1yvmA-2gtxA: 99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1YVM_A_TMGA501_1 (METHIONINE AMINOPEPTIDASE)	2gtx	METHIONINE AMINOPEPTIDASE (Escherichia coli)	6 / 7	CYH A 59 TYR A 65 CYH A 70 HIS A 79 HIS A 178 TRP A 221	NLP A3808 ( 3.8A) NLP A3808 ( 4.0A) NLP A3808 ( 3.7A) NLP A3808 (-3.8A) NLP A3808 (-3.9A) None	0.58A	1yvmA-2gtxA: 47.9	1yvmA-2gtxA: 99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNW_D_GCSD302_1 (25 KDA PROTEIN ELICITOR)	2gtx	METHIONINE AMINOPEPTIDASE (Escherichia coli)	4 / 7	GLY A 170 HIS A 171 ASP A 108 HIS A 79	None MN A 1 ( 3.8A) MN A 1 ( 2.8A) NLP A3808 (-3.8A)	0.63A	5nnwD-2gtxA: undetectable	5nnwD-2gtxA: 16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NO9_D_95ZD302_1 (25 KDA PROTEIN ELICITOR)	2gtx	METHIONINE AMINOPEPTIDASE (Escherichia coli)	4 / 7	GLY A 170 HIS A 171 ASP A 108 HIS A 79	None MN A 1 ( 3.8A) MN A 1 ( 2.8A) NLP A3808 (-3.8A)	0.64A	5no9D-2gtxA: undetectable	5no9D-2gtxA: 16.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YVM_A_TMGA501_1","METHIONINE AMINOPEPTIDASE","2gtx","METHIONINE AMINOPEPTIDASE","Escherichia coli",6,"CYH A  59;TYR A  62;TYR A  65;CYH A  70;HIS A  79;HIS A 178","NLP A3808 ( 3.8A);NLP A3808 ( 4.8A);NLP A3808 ( 4.0A);NLP A3808 ( 3.7A);NLP A3808 (-3.8A);NLP A3808 (-3.9A)","0.60A","1yvmA-2gtxA:47.9",null],["1YVM_A_TMGA501_1","METHIONINE AMINOPEPTIDASE","2gtx","METHIONINE AMINOPEPTIDASE","Escherichia coli",6,"CYH A  59;TYR A  65;CYH A  70;HIS A  79;HIS A 178;TRP A 221","NLP A3808 ( 3.8A);NLP A3808 ( 4.0A);NLP A3808 ( 3.7A);NLP A3808 (-3.8A);NLP A3808 (-3.9A);None","0.58A","1yvmA-2gtxA:47.9","1yvmA-2gtxA:99.62"],["5NNW_D_GCSD302_1","25 KDA PROTEIN ELICITOR","2gtx","METHIONINE AMINOPEPTIDASE","Escherichia coli",4,"GLY A 170;HIS A 171;ASP A 108;HIS A  79","None; MN A   1 ( 3.8A); MN A   1 ( 2.8A);NLP A3808 (-3.8A)","0.63A","5nnwD-2gtxA:undetectable","1yvmA-2gtxA:99.62"],["5NO9_D_95ZD302_1","25 KDA PROTEIN ELICITOR","2gtx","METHIONINE AMINOPEPTIDASE","Escherichia coli",4,"GLY A 170;HIS A 171;ASP A 108;HIS A  79","None; MN A   1 ( 3.8A); MN A   1 ( 2.8A);NLP A3808 (-3.8A)","0.64A","5no9D-2gtxA:undetectable","5nnwD-2gtxA:16.23"]]