SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NKN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX8_A_RTLA135_0 (CELLULAR RETINOL-BINDING PROTEIN I, HOLO)	3sao	EXTRACELLULAR FATTY ACID-BINDING PROTEIN (Gallus gallus)	5 / 12	PHE A 24 ALA A 143 TYR A 114 PHE A 65 ILE A 14	None None NKN A 161 (-4.0A) NKN A 161 (-4.6A) None	1.25A	1mx8A-3saoA: 5.6	1mx8A-3saoA: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SG8_A_TOYA305_1 (APH(2'')-ID)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	5 / 12	ASN A 231 ASP A 312 ASP A 474 HIS A 316 ASP A 172	NKN A 909 ( 3.2A) ZN A 903 ( 2.0A) None ZN A 903 ( 3.2A) ZN A 904 ( 2.2A)	1.37A	3sg8A-4zg7A: 0.0	3sg8A-4zg7A: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7H_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	3sao	EXTRACELLULAR FATTY ACID-BINDING PROTEIN (Gallus gallus)	3 / 3	ARG A 112 THR A 63 TRP A 61	NKN A 161 (-3.9A) None None	1.23A	4d7hA-3saoA: undetectable	4d7hA-3saoA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUB_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	3 / 3	TYR A 307 ARG A 285 HIS A 282	NKN A 909 (-3.6A) None None	1.17A	4fubA-4zg7A: undetectable	4fubA-4zg7A: 15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UG5_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	3sao	EXTRACELLULAR FATTY ACID-BINDING PROTEIN (Gallus gallus)	3 / 3	ARG A 112 THR A 63 TRP A 61	NKN A 161 (-3.9A) None None	1.19A	4ug5A-3saoA: undetectable	4ug5A-3saoA: 19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_A_5D5A930_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	10 / 12	LEU A 79 ASP A 172 THR A 210 PHE A 211 LEU A 214 PRO A 259 ILE A 262 PHE A 275 TRP A 276 ARG A 285	None ZN A 904 ( 2.2A) ZN A 904 ( 2.6A) NKN A 909 ( 4.7A) 4O0 A 908 ( 4.4A) 4O0 A 908 ( 4.9A) None 4O0 A 908 (-3.7A) None None	0.64A	5dlvA-4zg7A: 59.4	5dlvA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	11 / 12	LEU A 79 ASP A 172 THR A 210 PHE A 211 LEU A 214 PRO A 259 TRP A 261 ILE A 262 PHE A 275 TRP A 276 ARG A 285	None ZN A 904 ( 2.2A) ZN A 904 ( 2.6A) NKN A 909 ( 4.7A) 4O0 A 908 ( 4.4A) 4O0 A 908 ( 4.9A) 4O0 A 908 (-4.4A) None 4O0 A 908 (-3.7A) None None	0.59A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	4 / 7	LYS A 249 HIS A 252 TRP A 255 TYR A 307	4O0 A 908 (-4.0A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) NKN A 909 (-3.6A)	1.27A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	10 / 12	LEU A 79 SER A 82 PHE A 211 ARG A 247 LYS A 249 PHE A 250 TRP A 255 TRP A 261 PHE A 275 VAL A 278	None 4O0 A 908 ( 2.9A) NKN A 909 ( 4.7A) None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A) 4O0 A 908 (-3.7A) 4O0 A 908 ( 3.5A)	0.56A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	8 / 12	PHE A 211 ARG A 247 LYS A 249 PHE A 250 HIS A 252 TRP A 255 TRP A 261 PHE A 275	NKN A 909 ( 4.7A) None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A) 4O0 A 908 (-3.7A)	0.73A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	6 / 12	PHE A 211 LYS A 249 PHE A 250 HIS A 252 TRP A 255 TYR A 307	NKN A 909 ( 4.7A) 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) NKN A 909 (-3.6A)	1.22A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	6 / 12	PHE A 211 LYS A 249 PHE A 250 TRP A 255 VAL A 278 TYR A 307	NKN A 909 ( 4.7A) 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.3A) 4O0 A 908 ( 3.5A) NKN A 909 (-3.6A)	1.50A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	5 / 12	SER A 277 PHE A 211 HIS A 252 TRP A 255 TRP A 261	GOL A 910 ( 4.4A) NKN A 909 ( 4.7A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A)	1.45A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G6C_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	3sao	EXTRACELLULAR FATTY ACID-BINDING PROTEIN (Gallus gallus)	3 / 3	ARG A 112 THR A 63 TRP A 61	NKN A 161 (-3.9A) None None	1.19A	5g6cA-3saoA: undetectable	5g6cA-3saoA: 21.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX8_A_RTLA135_0","CELLULAR RETINOL-BINDING PROTEIN I, HOLO","3sao","EXTRACELLULAR FATTY ACID-BINDING PROTEIN","Gallus gallus",5,"PHE A  24;ALA A 143;TYR A 114;PHE A  65;ILE A  14","None;None;NKN A 161 (-4.0A);NKN A 161 (-4.6A);None","1.25A","1mx8A-3saoA:5.6",null],["3SG8_A_TOYA305_1","APH(2'')-ID","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",5,"ASN A 231;ASP A 312;ASP A 474;HIS A 316;ASP A 172","NKN A 909 ( 3.2A); ZN A 903 ( 2.0A);None; ZN A 903 ( 3.2A); ZN A 904 ( 2.2A)","1.37A","3sg8A-4zg7A:0.0","1mx8A-3saoA:22.93"],["4D7H_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","3sao","EXTRACELLULAR FATTY ACID-BINDING PROTEIN","Gallus gallus",3,"ARG A 112;THR A  63;TRP A  61","NKN A 161 (-3.9A);None;None","1.23A","4d7hA-3saoA:undetectable","3sg8A-4zg7A:16.79"],["4FUB_A_ACTA311_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",3,"TYR A 307;ARG A 285;HIS A 282","NKN A 909 (-3.6A);None;None","1.17A","4fubA-4zg7A:undetectable","4d7hA-3saoA:19.72"],["4UG5_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","3sao","EXTRACELLULAR FATTY ACID-BINDING PROTEIN","Gallus gallus",3,"ARG A 112;THR A  63;TRP A  61","NKN A 161 (-3.9A);None;None","1.19A","4ug5A-3saoA:undetectable","4fubA-4zg7A:15.65"],["5DLV_A_5D5A930_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",10,"LEU A  79;ASP A 172;THR A 210;PHE A 211;LEU A 214;PRO A 259;ILE A 262;PHE A 275;TRP A 276;ARG A 285","None; ZN A 904 ( 2.2A); ZN A 904 ( 2.6A);NKN A 909 ( 4.7A);4O0 A 908 ( 4.4A);4O0 A 908 ( 4.9A);None;4O0 A 908 (-3.7A);None;None","0.64A","5dlvA-4zg7A:59.4","4ug5A-3saoA:19.72"],["5DLV_B_5D5B927_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",11,"LEU A  79;ASP A 172;THR A 210;PHE A 211;LEU A 214;PRO A 259;TRP A 261;ILE A 262;PHE A 275;TRP A 276;ARG A 285","None; ZN A 904 ( 2.2A); ZN A 904 ( 2.6A);NKN A 909 ( 4.7A);4O0 A 908 ( 4.4A);4O0 A 908 ( 4.9A);4O0 A 908 (-4.4A);None;4O0 A 908 (-3.7A);None;None","0.59A","5dlvB-4zg7A:59.4","5dlvA-4zg7A:92.72"],["5DLV_B_5D5B927_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",4,"LYS A 249;HIS A 252;TRP A 255;TYR A 307","4O0 A 908 (-4.0A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);NKN A 909 (-3.6A)","1.27A","5dlvB-4zg7A:59.4","5dlvB-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",10,"LEU A  79;SER A  82;PHE A 211;ARG A 247;LYS A 249;PHE A 250;TRP A 255;TRP A 261;PHE A 275;VAL A 278","None;4O0 A 908 ( 2.9A);NKN A 909 ( 4.7A);None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A);4O0 A 908 (-3.7A);4O0 A 908 ( 3.5A)","0.56A","5dlwA-4zg7A:59.6","5dlvB-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",8,"PHE A 211;ARG A 247;LYS A 249;PHE A 250;HIS A 252;TRP A 255;TRP A 261;PHE A 275","NKN A 909 ( 4.7A);None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A);4O0 A 908 (-3.7A)","0.73A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",6,"PHE A 211;LYS A 249;PHE A 250;HIS A 252;TRP A 255;TYR A 307","NKN A 909 ( 4.7A);4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);NKN A 909 (-3.6A)","1.22A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",6,"PHE A 211;LYS A 249;PHE A 250;TRP A 255;VAL A 278;TYR A 307","NKN A 909 ( 4.7A);4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.3A);4O0 A 908 ( 3.5A);NKN A 909 (-3.6A)","1.50A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",5,"SER A 277;PHE A 211;HIS A 252;TRP A 255;TRP A 261","GOL A 910 ( 4.4A);NKN A 909 ( 4.7A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A)","1.45A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5G6C_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","3sao","EXTRACELLULAR FATTY ACID-BINDING PROTEIN","Gallus gallus",3,"ARG A 112;THR A  63;TRP A  61","NKN A 161 (-3.9A);None;None","1.19A","5g6cA-3saoA:undetectable","5dlwA-4zg7A:92.72"]]