SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NJP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 PHE A  92
TYR A 150
GLY A 186
VAL A 181
ASP A 138
 PG4  A 241 (-3.6A)
GOL  A 246 ( 4.4A)
PG4  A 241 ( 3.9A)
NJP  A 501 (-3.9A)
GOL  A 246 ( 2.4A)
 1.49A 1e3vA-3l77A:
undetectable		 1e3vA-3l77A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A   8
ARG A  33
ASP A  59
ASN A  86
ALA A  87
 NJP  A 501 (-3.3A)
NJP  A 501 (-3.5A)
NJP  A 501 (-3.6A)
NJP  A 501 (-3.3A)
NJP  A 501 (-3.5A)
 0.99A 2bm9E-3l77A:
5.9		 2bm9E-3l77A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A   8
ARG A  33
ASP A  59
SER A  61
ALA A  87
 NJP  A 501 (-3.3A)
NJP  A 501 (-3.5A)
NJP  A 501 (-3.6A)
PG4  A 245 ( 4.1A)
NJP  A 501 (-3.5A)
 0.85A 2br4C-3l77A:
6.0		 2br4C-3l77A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 GLY A   8
ALA A  16
ASP A  59
VAL A  60
VAL A 109
 NJP  A 501 (-3.3A)
None
NJP  A 501 (-3.6A)
NJP  A 501 (-3.6A)
NJP  A 501 (-4.6A)
 0.96A 3dmfA-3l77A:
6.3		 3dmfA-3l77A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 LEU A  38
ALA A  18
GLY A  14
SER A  10
LEU A  45
 None
None
None
NJP  A 501 (-2.7A)
None
 1.22A 3ou7A-3l77A:
5.5		 3ou7A-3l77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		5 / 12 LEU A  38
ALA A  18
GLY A  14
SER A  10
LEU A  45
 None
None
None
NJP  A 501 (-2.7A)
None
 1.26A 3ou7D-3l77A:
5.4		 3ou7D-3l77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 7 GLY A 148
GLY A 149
MET A 106
ASN A 110
 None
None
None
NJP  A 501 ( 4.8A)
 1.06A 4fgkB-3l77A:
7.0		 4fgkB-3l77A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.21A 6ew0B-3l77A:
undetectable		 6ew0B-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.21A 6ew0D-3l77A:
undetectable		 6ew0D-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.21A 6ew0H-3l77A:
undetectable		 6ew0H-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE
(Thermococcus
sibiricus) 		4 / 5 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.20A 6ew0I-3l77A:
undetectable		 6ew0I-3l77A:
15.52