SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NIS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2gjn HYPOTHETICAL PROTEIN
PA1024
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 103
GLY A 151
SER A 178
 FMN  A1904 (-3.1A)
NIS  A 500 (-2.8A)
FMN  A1904 (-3.2A)
 0.38A 2ivuA-2gjnA:
undetectable		 2ivuA-2gjnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gjn HYPOTHETICAL PROTEIN
PA1024
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 273
SER A 288
ALA A 289
VAL A 250
ILE A 246
 None
NIS  A 500 ( 3.2A)
None
None
None
 0.92A 3adxB-2gjnA:
undetectable		 3adxB-2gjnA:
22.82