SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NIL'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 VAL A 102
LEU A  55
LEU A  75
LEU A 104
LEU A  74
None
None
NIL  A   1 ( 4.8A)
NIL  A   1 ( 4.3A)
None
0.94A 1mx1F-3gp0A:
undetectable
1mx1F-3gp0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 ALA A  51
GLU A  71
LEU A  75
THR A 106
HIS A 148
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
0.51A 1uwhA-3gp0A:
22.5
1uwhA-3gp0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LYS A  53
GLU A  71
LEU A  75
THR A 106
HIS A 148
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
0.67A 1uwhB-3gp0A:
22.5
1uwhB-3gp0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 VAL A  38
ALA A  51
GLU A  71
THR A 106
HIS A 148
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
0.53A 1uwjA-3gp0A:
5.6
1uwjA-3gp0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 9 VAL A  38
LEU A  86
LEU A 104
LEU A 108
MET A 109
NIL  A   1 ( 4.7A)
None
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
None
0.63A 1xkkA-3gp0A:
20.5
1xkkA-3gp0A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 9 VAL A  38
LYS A  53
LEU A  86
LEU A 104
LEU A 108
NIL  A   1 ( 4.7A)
None
None
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
0.67A 1xkkA-3gp0A:
20.5
1xkkA-3gp0A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 ALA A  51
GLU A  71
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.36A 3cs9B-3gp0A:
22.5
3cs9B-3gp0A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 ALA A  51
GLU A  71
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.29A 3cs9C-3gp0A:
22.3
3cs9C-3gp0A:
25.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 ALA A  51
GLU A  71
LEU A  75
THR A 106
ILE A 141
HIS A 148
LEU A 167
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.3A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
0.79A 3gcsA-3gp0A:
40.6
3gcsA-3gp0A:
74.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 ALA A  51
LEU A  74
LEU A  75
THR A 106
ILE A 141
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.76A 3gcsA-3gp0A:
40.6
3gcsA-3gp0A:
74.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 ALA A  51
LEU A  75
ILE A  84
THR A 106
ILE A 141
HIS A 148
LEU A 167
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.3A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
0.80A 3gcsA-3gp0A:
40.6
3gcsA-3gp0A:
74.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 VAL A  38
ALA A  51
LEU A  74
LEU A  75
THR A 106
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
0.61A 3gcsA-3gp0A:
40.6
3gcsA-3gp0A:
74.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
4 / 5 LEU A 104
LYS A  76
LEU A  72
GLU A  71
NIL  A   1 ( 4.3A)
None
None
NIL  A   1 (-3.7A)
1.12A 3h5gA-3gp0A:
undetectable
3h5gB-3gp0A:
undetectable
3h5gA-3gp0A:
7.54
3h5gB-3gp0A:
7.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
9 / 12 ALA A  51
GLU A  71
LEU A  74
LEU A  75
THR A 106
LEU A 108
LEU A 167
ASP A 168
PHE A 169
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
0.70A 3hecA-3gp0A:
41.8
3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 ALA A  51
GLU A  71
LEU A  75
ILE A  84
THR A 106
LEU A 167
ASP A 168
PHE A 169
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
0.67A 3hecA-3gp0A:
41.8
3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LEU A  78
LEU A  75
ILE A  84
THR A 106
LEU A 167
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
1.49A 3hecA-3gp0A:
41.8
3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LYS A  53
THR A 106
LEU A 108
LEU A 167
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.0A)
NIL  A   1 (-4.6A)
0.73A 3hecA-3gp0A:
41.8
3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
9 / 12 VAL A  30
ALA A  51
GLU A  71
LEU A  74
LEU A  75
THR A 106
LEU A 108
ASP A 168
PHE A 169
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
0.82A 3hecA-3gp0A:
41.8
3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  30
ALA A  51
LYS A  53
THR A 106
LEU A 108
ASP A 168
None
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.6A)
0.61A 3hecA-3gp0A:
41.8
3hecA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
GLU A  71
LEU A  75
THR A 106
ILE A 141
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.6A)
0.73A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LEU A  74
LEU A  75
THR A 106
ILE A 141
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.6A)
0.75A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LEU A  75
ILE A  84
THR A 106
ILE A 141
ASP A 168
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.6A)
0.71A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LYS A  53
GLU A  71
THR A 106
ILE A 141
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.6A)
1.06A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ALA A  51
LYS A  53
ILE A  84
THR A 106
ILE A 141
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.6A)
1.08A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  30
VAL A  38
ALA A  51
GLU A  71
LEU A  75
THR A 106
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
0.84A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  30
VAL A  38
ALA A  51
LEU A  74
LEU A  75
THR A 106
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
0.66A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
GLU A  71
LEU A  75
THR A 106
ILE A 141
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
0.94A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
LEU A  74
LEU A  75
THR A 106
ILE A 141
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
0.91A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
ILE A 141
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
0.95A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 6 VAL A  83
ILE A 146
HIS A 148
ILE A 166
LEU A 167
NIL  A   1 (-4.9A)
None
NIL  A   1 (-4.3A)
NIL  A   1 ( 4.9A)
NIL  A   1 (-4.0A)
0.43A 3hegA-3gp0A:
42.4
3hegA-3gp0A:
75.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 8 VAL A  30
ALA A  51
GLU A  71
LEU A 104
LEU A 108
MET A 109
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
None
0.72A 3lfaA-3gp0A:
40.5
3lfaA-3gp0A:
75.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 8 VAL A  30
ALA A  51
GLU A  71
LEU A 104
THR A 106
LEU A 108
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
0.50A 3lfaA-3gp0A:
40.5
3lfaA-3gp0A:
75.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
ASN A 114
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
1.19A 3ohtA-3gp0A:
33.1
3ohtA-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
9 / 12 GLY A  31
VAL A  38
ALA A  51
LYS A  53
LEU A  75
ILE A  84
THR A 106
ASN A 115
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
1.04A 3ohtA-3gp0A:
33.1
3ohtA-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 VAL A  30
GLY A  31
VAL A  38
ALA A  51
LEU A  75
THR A 106
ASN A 114
LEU A 167
None
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
1.15A 3ohtA-3gp0A:
33.1
3ohtA-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 VAL A  30
GLY A  31
VAL A  38
ALA A  51
LEU A  75
THR A 106
ASN A 115
LEU A 167
None
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
1.15A 3ohtA-3gp0A:
33.1
3ohtA-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 VAL A  38
ALA A  51
LYS A  53
ILE A  84
THR A 106
ASN A 115
LEU A 167
PHE A 169
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
NIL  A   1 (-3.5A)
1.16A 3ohtA-3gp0A:
33.1
3ohtA-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_2
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
3 / 3 GLU A  71
LEU A 104
LEU A 108
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
0.34A 3ohtA-3gp0A:
33.1
3ohtA-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
ASN A 114
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
1.20A 3ohtB-3gp0A:
32.9
3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
0.73A 3ohtB-3gp0A:
32.9
3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
8 / 12 GLY A  31
VAL A  38
ALA A  51
LYS A  53
ILE A  84
THR A 106
ASN A 115
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
1.02A 3ohtB-3gp0A:
32.9
3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_2
(P38A)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
3 / 3 GLU A  71
LEU A 104
LEU A 108
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
0.33A 3ohtB-3gp0A:
32.9
3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
GLU A  71
LEU A  75
ILE A  84
HIS A 148
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-4.3A)
0.51A 3rgfA-3gp0A:
10.0
3rgfA-3gp0A:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
4 / 7 LYS A  53
LEU A  78
VAL A  83
ASP A 168
None
None
NIL  A   1 (-4.9A)
NIL  A   1 (-4.6A)
0.25A 3rgfA-3gp0A:
8.5
3rgfA-3gp0A:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 ALA A  51
LYS A  53
GLU A  71
ILE A  84
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.74A 3zosB-3gp0A:
22.0
3zosB-3gp0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
GLU A  71
ILE A  84
THR A 106
ASP A 168
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
0.52A 4bkjA-3gp0A:
22.2
4bkjA-3gp0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
GLU A  71
ILE A  84
THR A 106
ASP A 168
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
0.47A 4bkjB-3gp0A:
22.2
4bkjB-3gp0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 ALA A  51
LYS A  53
GLU A  71
LEU A  75
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.77A 4c8bA-3gp0A:
21.8
4c8bA-3gp0A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 ALA A  51
LYS A  53
GLU A  71
LEU A  75
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.71A 4c8bB-3gp0A:
22.0
4c8bB-3gp0A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 VAL A  38
ALA A  51
ILE A  84
ASP A 112
ASP A 150
LYS A 152
ASN A 155
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
None
None
None
None
0.71A 4i41A-3gp0A:
21.4
4i41A-3gp0A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
GLU A  71
THR A 106
ASP A 168
PHE A 169
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
0.71A 4r7iA-3gp0A:
22.2
4r7iA-3gp0A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 10 ALA A  51
LYS A  53
ILE A  84
THR A 106
LEU A 108
NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
0.55A 4rz7A-3gp0A:
8.0
4rz7A-3gp0A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 ALA A  51
LYS A  53
LEU A  75
THR A 106
HIS A 148
ASP A 168
PHE A 169
NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
1.02A 4u0iA-3gp0A:
22.2
4u0iA-3gp0A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
4 / 7 VAL A  38
LYS A  53
ILE A  84
ILE A 166
NIL  A   1 ( 4.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 ( 4.9A)
0.33A 4uxqA-3gp0A:
22.9
4uxqA-3gp0A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
3 / 3 PRO A  58
ILE A  84
SER A 100
None
NIL  A   1 (-4.4A)
None
0.67A 5fsaA-3gp0A:
undetectable
5fsaA-3gp0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 ARG A  28
VAL A  38
ALA A  51
THR A 106
LEU A 108
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
NIL  A   1 (-4.0A)
1.12A 5h2uA-3gp0A:
20.5
5h2uA-3gp0A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 9 GLY A  31
VAL A  38
ALA A  51
ILE A  84
MET A 109
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
None
NIL  A   1 (-4.0A)
0.89A 5lw1B-3gp0A:
37.6
5lw1B-3gp0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 10 GLY A  31
VAL A  38
ALA A  51
ILE A  84
LEU A 108
MET A 109
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 ( 4.4A)
None
NIL  A   1 (-4.0A)
0.83A 5lw1E-3gp0A:
37.2
5lw1E-3gp0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 9 GLY A  31
VAL A  38
ALA A  51
LEU A 108
MET A 109
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.4A)
None
NIL  A   1 (-4.0A)
0.79A 5lw1H-3gp0A:
37.5
5lw1H-3gp0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
GLU A  71
LEU A 104
THR A 106
GLY A 110
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 (-3.3A)
None
0.73A 5vcyA-3gp0A:
22.6
5vcyA-3gp0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
GLY A 110
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
None
0.84A 5vcyA-3gp0A:
22.6
5vcyA-3gp0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
5 / 12 ALA A 299
VAL A  83
VAL A 209
LEU A  74
LEU A  78
None
NIL  A   1 (-4.9A)
None
None
None
1.07A 5xxiA-3gp0A:
undetectable
5xxiA-3gp0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
7 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  71
ILE A  84
THR A 106
MET A 109
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
0.69A 6bsdA-3gp0A:
21.4
6bsdA-3gp0A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
ASP A 168
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
0.53A 6hd4A-3gp0A:
21.9
6hd4A-3gp0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
ASP A 168
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
0.58A 6hd4B-3gp0A:
21.8
6hd4B-3gp0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo
sapiens)
6 / 12 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
ASP A 168
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
0.53A 6hd6B-3gp0A:
21.8
6hd6B-3gp0A:
13.26