SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NHX'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEC_B_HAEB271_1 (COLLAGENASE 3)	3kds	CELL DIVISION PROTEIN FTSH (Thermotoga maritima)	3 / 3	HIS E 423 GLU E 424 HIS E 427	ZN E 996 ( 3.3A) NHX E 998 (-3.0A) ZN E 996 ( 3.3A)	0.19A	3kecB-3kdsE: undetectable	3kecB-3kdsE: 15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9S_A_BEZA264_0 (CARNITINYL-COA DEHYDRATASE)	3kds	CELL DIVISION PROTEIN FTSH (Thermotoga maritima)	4 / 6	ALA E 428 ILE E 582 LEU E 597 GLU E 424	None None None NHX E 998 (-3.0A)	0.83A	3r9sA-3kdsE: undetectable	3r9sA-3kdsE: 23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9S_C_BEZC264_0 (CARNITINYL-COA DEHYDRATASE)	3kds	CELL DIVISION PROTEIN FTSH (Thermotoga maritima)	4 / 6	ALA E 428 ILE E 582 LEU E 597 GLU E 424	None None None NHX E 998 (-3.0A)	0.89A	3r9sC-3kdsE: undetectable	3r9sC-3kdsE: 23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_G_SAMG501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	3kds	CELL DIVISION PROTEIN FTSH (Thermotoga maritima)	5 / 11	LEU E 480 GLY E 482 GLU E 424 GLY E 426 LEU E 476	None ZN E 996 ( 4.6A) NHX E 998 (-3.0A) None None	0.92A	5o96G-3kdsE: undetectable	5o96G-3kdsE: 20.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3KEC_B_HAEB271_1","COLLAGENASE 3","3kds","CELL DIVISION PROTEIN FTSH","Thermotoga maritima",3,"HIS E 423;GLU E 424;HIS E 427"," ZN E 996 ( 3.3A);NHX E 998 (-3.0A); ZN E 996 ( 3.3A)","0.19A","3kecB-3kdsE:undetectable",null],["3R9S_A_BEZA264_0","CARNITINYL-COA DEHYDRATASE","3kds","CELL DIVISION PROTEIN FTSH","Thermotoga maritima",4,"ALA E 428;ILE E 582;LEU E 597;GLU E 424","None;None;None;NHX E 998 (-3.0A)","0.83A","3r9sA-3kdsE:undetectable","3kecB-3kdsE:15.88"],["3R9S_C_BEZC264_0","CARNITINYL-COA DEHYDRATASE","3kds","CELL DIVISION PROTEIN FTSH","Thermotoga maritima",4,"ALA E 428;ILE E 582;LEU E 597;GLU E 424","None;None;None;NHX E 998 (-3.0A)","0.89A","3r9sC-3kdsE:undetectable","3r9sA-3kdsE:23.09"],["5O96_G_SAMG501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","3kds","CELL DIVISION PROTEIN FTSH","Thermotoga maritima",5,"LEU E 480;GLY E 482;GLU E 424;GLY E 426;LEU E 476","None; ZN E 996 ( 4.6A);NHX E 998 (-3.0A);None;None","0.92A","5o96G-3kdsE:undetectable","3r9sC-3kdsE:23.09"]]