SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NHW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 7 LEU A 403
TYR A 401
ASN A 246
TYR A 180
 None
None
NHW  A1000 (-4.8A)
NHW  A1000 ( 4.6A)
 1.38A 1afsA-4c2xA:
undetectable		 1afsA-4c2xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 7 LEU A 403
TYR A 401
ASN A 246
TYR A 180
 None
None
NHW  A1000 (-4.8A)
NHW  A1000 ( 4.6A)
 1.37A 1afsB-4c2xA:
undetectable		 1afsB-4c2xA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.24A 1h7xA-2yneA:
undetectable		 1h7xA-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.25A 1h7xB-2yneA:
undetectable		 1h7xB-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.24A 1h7xC-2yneA:
undetectable		 1h7xC-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.24A 1h7xD-2yneA:
undetectable		 1h7xD-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 6 ILE A 138
THR A 122
PHE A 119
TYR A 479
 None
None
None
NHW  A1000 ( 4.1A)
 1.27A 3elzB-4c2xA:
undetectable		 3elzB-4c2xA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 5 ILE A 138
THR A 122
PHE A 119
TYR A 479
 None
None
None
NHW  A1000 ( 4.1A)
 1.33A 3em0A-4c2xA:
undetectable		 3em0A-4c2xA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 7 LEU A 317
VAL A  96
LEU A 388
LEU A 116
 None
NHW  A1000 ( 4.0A)
YNE  A1001 (-4.2A)
None
 0.92A 3g8iA-2yneA:
undetectable		 3g8iA-2yneA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 GLY A 139
GLY A 128
LEU A 163
THR A  89
LEU A  90
 None
None
NHW  A1000 (-4.1A)
None
None
 1.00A 3mteB-2yneA:
undetectable		 3mteB-2yneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
NHW  A1000 (-4.0A)
None
None
 1.03A 3mteB-4c2xA:
undetectable		 3mteB-4c2xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 GLY A 139
GLY A 128
LEU A 163
THR A  89
LEU A  90
 None
None
NHW  A1000 (-4.1A)
None
None
 1.01A 3p2kB-2yneA:
undetectable		 3p2kB-2yneA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
NHW  A1000 (-4.0A)
None
None
 1.02A 3p2kB-4c2xA:
undetectable		 3p2kB-4c2xA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 8 PHE A 336
TRP A 114
ASN A 161
ILE A 148
 None
None
NHW  A1000 (-4.6A)
None
 0.85A 4qoiA-2yneA:
undetectable
4qoiB-2yneA:
undetectable		 4qoiA-2yneA:
20.41
4qoiB-2yneA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		4 / 8 PHE A 422
TRP A 199
ASN A 246
ILE A 233
 None
None
NHW  A1000 (-4.8A)
None
 0.85A 4qoiA-4c2xA:
undetectable
4qoiB-4c2xA:
undetectable		 4qoiA-4c2xA:
19.76
4qoiB-4c2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 LEU A  67
GLY A 128
TYR A  95
ILE A 138
LEU A 116
 None
None
NHW  A1000 (-4.3A)
None
None
 1.03A 5ycnA-2yneA:
undetectable		 5ycnA-2yneA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens) 		5 / 12 LEU A 175
TYR A 180
TYR A 192
PRO A 194
LEU A 172
 None
NHW  A1000 ( 4.6A)
None
None
None
 1.33A 6eliA-4c2xA:
undetectable		 6eliA-4c2xA:
9.73