SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NHR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 12 MET A  89
ILE A  91
LEU A  92
ASN A 106
VAL A 139
 GAR  A 221 ( 4.3A)
NHR  A 220 (-4.3A)
NHR  A 220 (-3.9A)
NHR  A 220 (-3.0A)
NHR  A 220 (-4.5A)
 0.78A 3dcjA-1c3eA:
14.1
3dcjB-1c3eA:
28.4		 3dcjA-1c3eA:
32.89
3dcjB-1c3eA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 8 ILE A  91
LEU A  92
ASN A 106
VAL A 139
 NHR  A 220 (-4.3A)
NHR  A 220 (-3.9A)
NHR  A 220 (-3.0A)
NHR  A 220 (-4.5A)
 0.63A 3dcjB-1c3eA:
28.4		 3dcjB-1c3eA:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 7 TYR A 100
LEU A  85
LEU A  92
SER A  98
 None
NHR  A 220 ( 4.8A)
NHR  A 220 (-3.9A)
None
 1.03A 3lm8A-1c3eA:
4.9
3lm8C-1c3eA:
5.7		 3lm8A-1c3eA:
24.81
3lm8C-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		3 / 3 PRO A  94
VAL A 139
HIS A 137
 None
NHR  A 220 (-4.5A)
None
 0.84A 4pevC-1c3eA:
2.4		 4pevC-1c3eA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 5 SER A  93
ARG A  64
ASP A  68
ARG A  90
 None
NHR  A 220 (-3.1A)
None
None
 1.17A 6dwdA-1c3eA:
0.0		 6dwdA-1c3eA:
16.33