SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NHM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Aspergillus
fumigatus) 		5 / 12 ALA A 183
LEU A 120
ILE A 217
LEU A 230
THR A 184
 None
None
NHM  A 504 (-4.2A)
None
None
 1.10A 4ej1B-4qbjA:
undetectable		 4ej1B-4qbjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Aspergillus
fumigatus) 		4 / 4 HIS A 458
ALA A 250
VAL A 252
GLU A 149
 None
NHM  A 504 ( 3.9A)
None
NHM  A 504 (-4.0A)
 1.29A 4n6pA-4qbjA:
undetectable		 4n6pA-4qbjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 183
VAL A 173
VAL A 137
PHE A 148
LEU A 171
 NHM  A 500 (-3.7A)
NHM  A 500 (-4.3A)
None
None
NHM  A 500 (-4.1A)
 1.50A 4wnvA-1iidA:
0.0		 4wnvA-1iidA:
22.65