SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NGA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4g9n AGGLUTININ
(Rhizoctonia
solani) 		4 / 4 GLY A  26
ASP A  22
GLY A  41
THR A   9
 None
NGA  A 201 (-2.8A)
None
None
 1.10A 1hxbB-4g9nA:
undetectable		 1hxbB-4g9nA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 3rsj BONT/F
(Clostridium
botulinum) 		6 / 9 GLU A1195
GLY A1239
HIS A1241
SER A1248
TRP A1250
TYR A1251
 NGA  A   3 ( 3.1A)
None
GAL  A   4 ( 4.2A)
GAL  A   4 (-2.7A)
GAL  A   4 (-4.1A)
GAL  A   4 ( 4.4A)
 0.70A 1i1eA-3rsjA:
28.6		 1i1eA-3rsjA:
15.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 5n0c TETANUS TOXIN
(Clostridium
tetani) 		5 / 9 GLY A1269
HIS A1271
SER A1287
TRP A1289
TYR A1290
 None
GAL  A1404 ( 4.2A)
NGA  A1403 ( 3.7A)
GAL  A1404 ( 3.9A)
GAL  A1404 (-4.4A)
 0.73A 1i1eA-5n0cA:
52.6		 1i1eA-5n0cA:
41.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 GLU A1203
GLY A1251
HIS A1253
SER A1264
TYR A1267
 NGA  A1303 (-3.1A)
None
GAL  A1304 (-3.7A)
GAL  A1304 (-2.7A)
GAL  A1304 ( 4.2A)
 0.59A 1i1eA-5tpcA:
29.7		 1i1eA-5tpcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 GLU A1203
GLY A1251
SER A1264
TRP A1266
TYR A1267
 NGA  A1303 (-3.1A)
None
GAL  A1304 (-2.7A)
GAL  A1304 ( 4.1A)
GAL  A1304 ( 4.2A)
 0.66A 1i1eA-5tpcA:
29.7		 1i1eA-5tpcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		5 / 12 HIS A1392
ALA A1484
GLY A1429
LEU A1401
PRO A1402
 NGA  A2494 (-3.6A)
None
None
None
None
 1.14A 1mjqC-4a45A:
undetectable
1mjqD-4a45A:
undetectable		 1mjqC-4a45A:
18.12
1mjqD-4a45A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		5 / 12 HIS A1392
ALA A1484
GLY A1429
LEU A1401
PRO A1402
 NGA  A2494 (-3.6A)
None
None
None
None
 1.15A 1mjqI-4a45A:
undetectable
1mjqJ-4a45A:
undetectable		 1mjqI-4a45A:
18.12
1mjqJ-4a45A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		5 / 11 ALA A 324
GLY A 285
GLU A 320
ASN A 215
TYR A 295
 None
None
NGA  A 502 (-2.9A)
None
None
 1.39A 1n6cA-2gamA:
undetectable		 1n6cA-2gamA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		3 / 3 GLN A 347
HIS A  48
ARG A  49
 None
None
NGA  A   2 (-3.0A)
 1.08A 1zlqA-2z8eA:
1.0		 1zlqA-2z8eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		4 / 8 SER A1368
ALA A1379
ALA A1486
ARG A1423
 None
None
None
NGA  A2494 (-2.6A)
 0.72A 2bxmA-4a45A:
undetectable		 2bxmA-4a45A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		4 / 8 GLY A 343
GLU A 345
THR A 220
ILE A 341
 NGA  A 702 (-3.4A)
NGA  A 702 (-2.9A)
UDP  A 705 ( 3.9A)
UDP  A 705 (-4.3A)
 0.86A 2dtjA-2d7iA:
undetectable
2dtjB-2d7iA:
undetectable		 2dtjA-2d7iA:
16.13
2dtjB-2d7iA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4uap GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 7 ARG A  76
ASP A  39
THR A 140
ILE A  85
 NGA  A 201 (-2.7A)
None
NGA  A 201 ( 4.6A)
None
 1.15A 2jc9A-4uapA:
undetectable		 2jc9A-4uapA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		3 / 3 ARG A 221
GLU A 340
SER A 238
 NGA  A 702 (-3.6A)
None
UDP  A 705 (-2.8A)
 0.94A 2xkkA-2d7iA:
1.7
2xkkC-2d7iA:
undetectable		 2xkkA-2d7iA:
20.46
2xkkC-2d7iA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 GLY A 319
ALA A 318
VAL A 262
VAL A 368
ILE A 266
 NGA  A 702 (-3.7A)
NGA  A 702 (-3.0A)
None
None
NGA  A 702 ( 4.6A)
 0.98A 3cyxA-2d7iA:
undetectable		 3cyxA-2d7iA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 SER A 260
PHE A 261
ASP A 202
LEU A 282
 None
None
None
NGA  A   2 (-4.8A)
 1.08A 3jq7B-2z8eA:
undetectable		 3jq7B-2z8eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 SER A 260
PHE A 261
ASP A 202
LEU A 282
 None
None
None
NGA  A   2 (-4.8A)
 1.06A 3jq7C-2z8eA:
undetectable		 3jq7C-2z8eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 9 GLY A 319
ALA A 318
VAL A 262
VAL A 368
ILE A 266
 NGA  A 702 (-3.7A)
NGA  A 702 (-3.0A)
None
None
NGA  A 702 ( 4.6A)
 0.90A 3oxvA-2d7iA:
undetectable		 3oxvA-2d7iA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 GLY A 319
ALA A 318
VAL A 262
VAL A 368
ILE A 266
 NGA  A 702 (-3.7A)
NGA  A 702 (-3.0A)
None
None
NGA  A 702 ( 4.6A)
 1.00A 3oxxC-2d7iA:
undetectable		 3oxxC-2d7iA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4a45 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN
(Clostridium
perfringens) 		4 / 6 ASN A1430
TYR A1395
GLU A1376
ILE A1390
 None
NGA  A2494 (-3.3A)
NGA  A2494 (-2.7A)
None
 0.92A 3q5sA-4a45A:
undetectable		 3q5sA-4a45A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE
(Mus
musculus) 		3 / 3 ASN A 250
GLU A 253
ARG A 254
 NGA  A 502 (-3.8A)
None
NGA  A 502 (-3.0A)
 0.90A 3wxoA-2gamA:
undetectable		 3wxoA-2gamA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4g9n AGGLUTININ
(Rhizoctonia
solani) 		4 / 7 GLU A 121
ASP A  22
ASN A  44
TRP A  24
 NGA  A 201 (-3.4A)
NGA  A 201 (-2.8A)
NGA  A 201 (-3.2A)
NGA  A 201 ( 4.1A)
 1.22A 4ii8A-4g9nA:
undetectable		 4ii8A-4g9nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		5 / 12 PRO A 263
MET A 237
LEU A 265
GLY A 141
ASP A 140
 None
None
None
None
NGA  A 870 (-3.0A)
 1.40A 4mubA-1ktcA:
undetectable		 4mubA-1ktcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 SER A 172
TYR A 176
ASP A  61
 NGA  A 870 (-2.6A)
None
NGA  A 870 (-2.9A)
 0.89A 4rp8C-1ktcA:
0.0		 4rp8C-1ktcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 11 TRP A 163
GLY A 134
ASP A 117
ALA A 116
TYR A  74
 None
NGA  A 307 ( 3.8A)
NGA  A 307 (-2.7A)
NGA  A 307 ( 4.3A)
None
 1.46A 5c8tB-5kxbA:
undetectable		 5c8tB-5kxbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 ASN A 303
PRO A  77
ASP A  40
ASN A 289
HIS A 236
 None
None
CA  A 603 (-3.0A)
CA  A 603 (-2.9A)
NGA  A 604 (-3.3A)
 1.42A 5dv4A-4fdjA:
undetectable		 5dv4A-4fdjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 5 ILE A  46
GLN A  80
ARG A  79
GLU A  43
 None
None
NGA  A 201 (-2.3A)
None
 1.21A 5fseC-4p5yA:
undetectable		 5fseC-4p5yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 ARG A 121
ASN A 116
ASP A 146
 None
None
NGA  A 201 ( 4.7A)
 0.85A 5gwxA-4p5yA:
undetectable		 5gwxA-4p5yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens) 		5 / 12 ILE A 349
VAL A 206
VAL A 324
ARG A 221
LEU A 182
 None
None
None
NGA  A 702 (-3.6A)
None
 1.17A 6a7pB-2d7iA:
undetectable		 6a7pB-2d7iA:
21.32