SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NFV'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_H_ACTH3006_0 (BETA-CARBONIC ANHYDRASE)	3myr	NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT (Allochromatium vinosum)	4 / 6	CYH B1064 VAL B1063 HIS B1068 CYH B1558	NFV B2005 (-2.3A) NFV B2005 ( 4.8A) NFV B2005 (-4.0A) NFV B2005 (-2.3A)	1.42A	1ekjG-3myrB: undetectable 1ekjH-3myrB: undetectable	1ekjG-3myrB: 17.24 1ekjH-3myrB: 17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQU_A_EQIA329_0 (PROTEIN (ESTRADIOL 17 BETA-DEHYDROGENASE 1))	3myr	NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT (Allochromatium vinosum)	5 / 10	VAL B1388 TYR B1526 PRO B1509 HIS B1104 GLU B1436	None None NFV B2005 (-3.5A) None None	1.43A	1equA-3myrB: undetectable	1equA-3myrB: 23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P9G_A_ACTA42_0 (EAFP 2)	3myr	NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT (Allochromatium vinosum)	3 / 3	CYH B1064 ARG B1487 CYH B1061	NFV B2005 (-2.3A) NFV B2005 (-3.8A) NFV B2005 (-2.2A)	1.42A	1p9gA-3myrB: undetectable	1p9gA-3myrB: 6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_A_PFNA1374_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	3myr	NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT (Allochromatium vinosum)	4 / 6	PRO B1509 SER B1510 GLU B1014 CYH B1064	NFV B2005 (-3.5A) NFV B2005 (-2.9A) None NFV B2005 (-2.3A)	1.07A	2x7hA-3myrB: undetectable	2x7hA-3myrB: 22.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_H_ACTH3006_0","BETA-CARBONIC ANHYDRASE","3myr","NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT","Allochromatium vinosum",4,"CYH B1064;VAL B1063;HIS B1068;CYH B1558","NFV B2005 (-2.3A);NFV B2005 ( 4.8A);NFV B2005 (-4.0A);NFV B2005 (-2.3A)","1.42A","1ekjG-3myrB:undetectable;1ekjH-3myrB:undetectable",null],["1EQU_A_EQIA329_0","PROTEIN (ESTRADIOL 17 BETA-DEHYDROGENASE 1)","3myr","NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT","Allochromatium vinosum",5,"VAL B1388;TYR B1526;PRO B1509;HIS B1104;GLU B1436","None;None;NFV B2005 (-3.5A);None;None","1.43A","1equA-3myrB:undetectable","1ekjG-3myrB:17.24;1ekjH-3myrB:17.24"],["1P9G_A_ACTA42_0","EAFP 2","3myr","NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT","Allochromatium vinosum",3,"CYH B1064;ARG B1487;CYH B1061","NFV B2005 (-2.3A);NFV B2005 (-3.8A);NFV B2005 (-2.2A)","1.42A","1p9gA-3myrB:undetectable","1equA-3myrB:23.60"],["2X7H_A_PFNA1374_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","3myr","NICKEL-DEPENDENT HYDROGENASE LARGE SUBUNIT","Allochromatium vinosum",4,"PRO B1509;SER B1510;GLU B1014;CYH B1064","NFV B2005 (-3.5A);NFV B2005 (-2.9A);None;NFV B2005 (-2.3A)","1.07A","2x7hA-3myrB:undetectable","1p9gA-3myrB:6.17"]]