SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NFU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1a7yA-3rgwL:
undetectable		 1a7yA-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1a7yA-4c3oA:
undetectable		 1a7yA-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.84A 1a7yB-3rgwL:
undetectable		 1a7yB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.84A 1a7yB-4c3oA:
undetectable		 1a7yB-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 6 CYH L  78
VAL L  77
HIS L  82
CYH L 600
 NFU  L1004 (-2.2A)
None
NFU  L1004 (-4.0A)
NFU  L1004 (-2.2A)
 1.43A 1ekjG-3rgwL:
undetectable
1ekjH-3rgwL:
undetectable		 1ekjG-3rgwL:
15.97
1ekjH-3rgwL:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 10 VAL A 413
TYR A 551
PRO A 534
HIS A 119
GLU A 461
 None
None
NFU  A1004 (-3.8A)
None
None
 1.42A 1equA-4c3oA:
undetectable		 1equA-4c3oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.86A 1hxbA-5odrF:
undetectable		 1hxbA-5odrF:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.74A 1i3wE-3rgwL:
undetectable		 1i3wE-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.76A 1i3wE-4c3oA:
undetectable		 1i3wE-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.79A 1i3wE-3rgwL:
undetectable		 1i3wE-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.80A 1i3wE-4c3oA:
undetectable		 1i3wE-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1i3wF-3rgwL:
undetectable		 1i3wF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1i3wF-4c3oA:
undetectable		 1i3wF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.79A 1i3wG-3rgwL:
undetectable		 1i3wG-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.80A 1i3wG-4c3oA:
undetectable		 1i3wG-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.82A 1i3wG-3rgwL:
undetectable		 1i3wG-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.82A 1i3wG-4c3oA:
undetectable		 1i3wG-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.82A 1i3wH-3rgwL:
undetectable		 1i3wH-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.83A 1i3wH-4c3oA:
undetectable		 1i3wH-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.76A 1mnvD-3rgwL:
undetectable		 1mnvD-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.76A 1mnvD-4c3oA:
undetectable		 1mnvD-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1mnvD-3rgwL:
undetectable		 1mnvD-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1mnvD-4c3oA:
undetectable		 1mnvD-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.77A 1ovfB-3rgwL:
undetectable		 1ovfB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.78A 1ovfB-4c3oA:
undetectable		 1ovfB-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 CYH L  78
ARG L 530
CYH L  75
 NFU  L1004 (-2.2A)
NFU  L1004 (-4.2A)
NFU  L1004 (-2.2A)
 1.40A 1p9gA-3rgwL:
undetectable		 1p9gA-3rgwL:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		3 / 3 CYH F  64
ARG F 375
CYH F  61
 NFU  F 501 (-2.2A)
NFU  F 501 (-4.2A)
NFU  F 501 (-2.2A)
 1.47A 1p9gA-5odrF:
undetectable		 1p9gA-5odrF:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.73A 1qfiA-3rgwL:
undetectable		 1qfiA-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.74A 1qfiA-4c3oA:
undetectable		 1qfiA-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.86A 1qfiB-3rgwL:
undetectable		 1qfiB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 10 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.93A 1sh9B-5odrF:
undetectable		 1sh9B-5odrF:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.81A 1unjF-3rgwL:
undetectable		 1unjF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.80A 1unjF-4c3oA:
undetectable		 1unjF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1unjF-3rgwL:
undetectable		 1unjF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.76A 1unjF-4c3oA:
undetectable		 1unjF-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.87A 1unjL-3rgwL:
undetectable		 1unjL-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.87A 1unjL-4c3oA:
undetectable		 1unjL-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.85A 1unjL-3rgwL:
undetectable		 1unjL-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.85A 1unjL-4c3oA:
undetectable		 1unjL-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.87A 1unjR-3rgwL:
undetectable		 1unjR-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.86A 1unjR-4c3oA:
undetectable		 1unjR-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.82A 1unjR-3rgwL:
undetectable		 1unjR-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.83A 1unjR-4c3oA:
undetectable		 1unjR-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.86A 1unjX-3rgwL:
undetectable		 1unjX-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.87A 1unjX-4c3oA:
undetectable		 1unjX-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.84A 1unjX-3rgwL:
undetectable		 1unjX-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 535
THR A 536
PRO A 534
 NFU  A1004 (-3.7A)
None
NFU  A1004 (-3.8A)
 0.85A 1unjX-4c3oA:
undetectable		 1unjX-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.87A 1unmF-3rgwL:
undetectable		 1unmF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.86A 1unmF-3rgwL:
undetectable		 1unmF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.83A 2avvE-5odrF:
undetectable		 2avvE-5odrF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 LEU F 240
GLY F 376
SER F 293
ALA F 373
ALA F  67
 None
None
None
NFU  F 501 (-3.1A)
NFU  F 501 ( 4.5A)
 1.12A 2br4F-5odrF:
undetectable		 2br4F-5odrF:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 7 ASP L 372
THR L 345
ILE L 352
PHE L  25
 None
NFU  L 401 (-3.7A)
None
None
 1.06A 2jc9A-6cfwL:
2.5		 2jc9A-6cfwL:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 LEU F  70
GLY F  98
ALA F  99
ILE F  63
PRO F  58
 None
None
None
NFU  F 501 ( 4.7A)
None
 0.99A 2nnkA-5odrF:
undetectable		 2nnkA-5odrF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.89A 2nnkA-5odrF:
undetectable		 2nnkA-5odrF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 11 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.92A 2nnpA-5odrF:
undetectable		 2nnpA-5odrF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.88A 2pymB-5odrF:
undetectable		 2pymB-5odrF:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 ALA A 417
THR A 535
GLY A 549
GLN A   8
PRO A 404
 None
NFU  A1004 (-3.7A)
None
None
None
 1.17A 2ve3B-4c3oA:
undetectable		 2ve3B-4c3oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 397
VAL F 396
THR F  57
THR F 399
 NFU  F 501 (-4.4A)
None
None
NFU  F 501 (-3.7A)
 1.14A 3bjwA-5odrF:
undetectable		 3bjwA-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 396
VAL F 397
THR E 114
THR F 377
 None
NFU  F 501 (-4.4A)
None
None
 1.21A 3bjwA-5odrF:
undetectable		 3bjwA-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 397
VAL F 396
THR F  57
THR F 399
 NFU  F 501 (-4.4A)
None
None
NFU  F 501 (-3.7A)
 1.18A 3bjwG-5odrF:
undetectable		 3bjwG-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 396
VAL F 397
THR E 114
THR F 377
 None
NFU  F 501 (-4.4A)
None
None
 1.23A 3bjwG-5odrF:
undetectable		 3bjwG-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 397
VAL F 396
THR F  57
THR F 399
 NFU  F 501 (-4.4A)
None
None
NFU  F 501 (-3.7A)
 1.19A 3bjwC-5odrF:
undetectable		 3bjwC-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 397
VAL F 396
THR F  57
THR F 399
 NFU  F 501 (-4.4A)
None
None
NFU  F 501 (-3.7A)
 1.14A 3bjwD-5odrF:
undetectable		 3bjwD-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 VAL F 396
VAL F 397
THR E 114
THR F 377
 None
NFU  F 501 (-4.4A)
None
None
 1.24A 3bjwD-5odrF:
undetectable		 3bjwD-5odrF:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		3 / 3 ASN C 125
HIS C 124
VAL C 500
 None
None
NFU  C 701 (-3.9A)
 0.86A 3elzB-5aa5C:
undetectable		 3elzB-5aa5C:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 ARG F 375
MET F 110
LEU E  41
ILE E 156
PHE E  82
 NFU  F 501 (-4.2A)
None
None
None
None
 1.45A 3mneA-5odrF:
undetectable		 3mneA-5odrF:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 LEU F 443
THR F 399
LEU F 111
MET F 406
PHE F  33
 None
NFU  F 501 (-3.7A)
None
None
None
 1.49A 3n58D-5odrF:
undetectable		 3n58D-5odrF:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 LEU F  70
GLY F  98
ALA F  99
ILE F  63
PRO F  58
 None
None
None
NFU  F 501 ( 4.7A)
None
 0.95A 3ndtC-5odrF:
undetectable		 3ndtC-5odrF:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.82A 3ndxA-5odrF:
undetectable		 3ndxA-5odrF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.86A 3oxcA-5odrF:
undetectable		 3oxcA-5odrF:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 LEU F  70
GLY F  98
ALA F  99
ILE F  63
PRO F  58
 None
None
None
NFU  F 501 ( 4.7A)
None
 0.98A 3pwrA-5odrF:
undetectable		 3pwrA-5odrF:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLY F  14
ILE F  60
GLY F  62
ILE E  17
PRO F 374
 None
None
None
None
NFU  F 501 (-3.5A)
 0.88A 3pwrA-5odrF:
undetectable		 3pwrA-5odrF:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 GLY C 270
PRO C 523
GLY C 502
LEU C 387
ASP C 380
 None
NFU  C 701 (-3.3A)
None
None
None
 1.40A 3r24A-5aa5C:
undetectable		 3r24A-5aa5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus;
Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLU E  57
GLY E  58
SER E  18
CYH F 442
CYH F 445
 SF4  E 302 (-3.8A)
SF4  E 302 ( 4.9A)
None
NFU  F 501 (-2.2A)
NFU  F 501 (-2.4A)
 1.23A 3rq4A-5odrE:
undetectable		 3rq4A-5odrE:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus;
Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLU E  57
GLY E  58
SER E  18
CYH F 442
CYH F 445
 SF4  E 302 (-3.8A)
SF4  E 302 ( 4.9A)
None
NFU  F 501 (-2.2A)
NFU  F 501 (-2.4A)
 1.28A 3s8pB-5odrE:
undetectable		 3s8pB-5odrE:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 LEU L 113
THR L 553
THR L 554
ILE L 399
ILE L  74
 None
NFU  L1004 (-3.8A)
None
None
None
 1.18A 3sp9A-3rgwL:
undetectable		 3sp9A-3rgwL:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 114
THR A 535
THR A 536
ILE A 401
ILE A  75
 None
NFU  A1004 (-3.7A)
None
None
None
 1.04A 3sp9A-4c3oA:
undetectable		 3sp9A-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 114
THR A 535
THR A 536
ILE A 401
VAL A  78
 None
NFU  A1004 (-3.7A)
None
None
None
 1.13A 3sp9A-4c3oA:
undetectable		 3sp9A-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 LEU A 114
THR A 535
THR A 536
ILE A 401
VAL A  78
 None
NFU  A1004 (-3.7A)
None
None
None
 1.14A 3sp9B-4c3oA:
undetectable		 3sp9B-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 LEU F  70
GLY F  98
ALA F  99
ILE F  63
PRO F  58
 None
None
None
NFU  F 501 ( 4.7A)
None
 0.97A 3tkgB-5odrF:
undetectable		 3tkgB-5odrF:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus;
Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLU E  57
GLY E  58
SER E  18
CYH F 442
CYH F 445
 SF4  E 302 (-3.8A)
SF4  E 302 ( 4.9A)
None
NFU  F 501 (-2.2A)
NFU  F 501 (-2.4A)
 1.26A 4bupA-5odrE:
undetectable		 4bupA-5odrE:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 12 ILE L 368
ALA L 353
PHE L  25
THR L 345
LEU L 375
 None
None
None
NFU  L 401 (-3.7A)
None
 1.26A 4cd2A-6cfwL:
undetectable		 4cd2A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 THR C 524
GLY C 577
PRO C 575
GLY C  82
 NFU  C 701 (-3.8A)
None
None
None
 0.84A 4fjpA-5aa5C:
undetectable		 4fjpA-5aa5C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.82A 4hivD-3rgwL:
undetectable		 4hivD-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 THR A 536
PRO A 534
THR A 535
 None
NFU  A1004 (-3.8A)
NFU  A1004 (-3.7A)
 0.81A 4hivD-4c3oA:
undetectable		 4hivD-4c3oA:
2.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 4 HIS A 122
GLU A 461
HIS A 115
LEU A 515
 None
None
None
NFU  A1004 (-3.7A)
 1.08A 4m2rA-4c3oA:
undetectable		 4m2rA-4c3oA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT
(Salmonella
enterica) 		4 / 6 GLU B  22
THR B  18
THR A 535
LEU A 126
 None
None
NFU  A1004 (-3.7A)
None
 0.96A 4pgfA-4c3oB:
3.3		 4pgfA-4c3oB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qvlV-4c3oA:
undetectable
4qvlb-4c3oA:
undetectable		 4qvlV-4c3oA:
18.17
4qvlb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qvlH-4c3oA:
undetectable
4qvlN-4c3oA:
undetectable		 4qvlH-4c3oA:
18.17
4qvlN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qvmV-3rgwL:
undetectable
4qvmb-3rgwL:
undetectable		 4qvmV-3rgwL:
16.21
4qvmb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qvmV-4c3oA:
undetectable
4qvmb-4c3oA:
undetectable		 4qvmV-4c3oA:
18.17
4qvmb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qvmH-3rgwL:
undetectable
4qvmN-3rgwL:
undetectable		 4qvmH-3rgwL:
16.21
4qvmN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qvmH-4c3oA:
undetectable
4qvmN-4c3oA:
undetectable		 4qvmH-4c3oA:
18.17
4qvmN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.34A 4qvpV-3rgwL:
undetectable
4qvpb-3rgwL:
undetectable		 4qvpV-3rgwL:
16.21
4qvpb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.27A 4qvpV-4c3oA:
undetectable
4qvpb-4c3oA:
undetectable		 4qvpV-4c3oA:
18.17
4qvpb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.27A 4qvpH-4c3oA:
undetectable
4qvpN-4c3oA:
undetectable		 4qvpH-4c3oA:
18.17
4qvpN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.32A 4qvqV-3rgwL:
undetectable
4qvqb-3rgwL:
undetectable		 4qvqV-3rgwL:
16.21
4qvqb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qvqV-4c3oA:
undetectable
4qvqb-4c3oA:
undetectable		 4qvqV-4c3oA:
18.17
4qvqb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qvqH-3rgwL:
undetectable
4qvqN-3rgwL:
undetectable		 4qvqH-3rgwL:
16.21
4qvqN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.26A 4qvqH-4c3oA:
undetectable
4qvqN-4c3oA:
undetectable		 4qvqH-4c3oA:
18.17
4qvqN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.26A 4qvwV-4c3oA:
undetectable
4qvwb-4c3oA:
undetectable		 4qvwV-4c3oA:
18.17
4qvwb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.34A 4qvwH-3rgwL:
undetectable
4qvwN-3rgwL:
undetectable		 4qvwH-3rgwL:
16.21
4qvwN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qvwH-4c3oA:
undetectable
4qvwN-4c3oA:
undetectable		 4qvwH-4c3oA:
18.17
4qvwN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qw0V-4c3oA:
undetectable
4qw0b-4c3oA:
undetectable		 4qw0V-4c3oA:
18.17
4qw0b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 4qw0H-4c3oA:
undetectable
4qw0N-4c3oA:
undetectable		 4qw0H-4c3oA:
18.17
4qw0N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qw1V-4c3oA:
undetectable
4qw1b-4c3oA:
undetectable		 4qw1V-4c3oA:
18.17
4qw1b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qw1H-4c3oA:
undetectable
4qw1N-4c3oA:
undetectable		 4qw1H-4c3oA:
18.17
4qw1N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.32A 4qw3V-3rgwL:
undetectable
4qw3b-3rgwL:
undetectable		 4qw3V-3rgwL:
16.21
4qw3b-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 4qw3V-4c3oA:
undetectable
4qw3b-4c3oA:
undetectable		 4qw3V-4c3oA:
18.17
4qw3b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qw3H-3rgwL:
undetectable
4qw3N-3rgwL:
undetectable		 4qw3H-3rgwL:
16.21
4qw3N-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.25A 4qw3H-4c3oA:
undetectable
4qw3N-4c3oA:
undetectable		 4qw3H-4c3oA:
18.17
4qw3N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		3 / 3 VAL A  67
PHE C 127
ARG C 501
 None
None
NFU  C 701 (-4.6A)
 0.80A 4xr4B-5aa5A:
undetectable		 4xr4B-5aa5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5bxnV-3rgwL:
undetectable
5bxnb-3rgwL:
undetectable		 5bxnV-3rgwL:
16.21
5bxnb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.21A 5bxnV-4c3oA:
undetectable
5bxnb-4c3oA:
undetectable		 5bxnV-4c3oA:
18.34
5bxnb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 5bxnH-4c3oA:
undetectable
5bxnN-4c3oA:
undetectable		 5bxnH-4c3oA:
18.34
5bxnN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
(Methanothermococ
cus
thermolithotroph
icus;
Methanothermococ
cus
thermolithotroph
icus) 		5 / 12 GLU E  57
GLY E  58
SER E  18
CYH F 442
CYH F 445
 SF4  E 302 (-3.8A)
SF4  E 302 ( 4.9A)
None
NFU  F 501 (-2.2A)
NFU  F 501 (-2.4A)
 1.29A 5cprB-5odrE:
undetectable		 5cprB-5odrE:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.34A 5cz7H-3rgwL:
undetectable
5cz7N-3rgwL:
undetectable		 5cz7H-3rgwL:
16.21
5cz7N-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.26A 5cz7H-4c3oA:
undetectable
5cz7N-4c3oA:
undetectable		 5cz7H-4c3oA:
18.17
5cz7N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.32A 5d0xV-3rgwL:
undetectable
5d0xb-3rgwL:
undetectable		 5d0xV-3rgwL:
16.21
5d0xb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 5d0xV-4c3oA:
undetectable
5d0xb-4c3oA:
undetectable		 5d0xV-4c3oA:
18.17
5d0xb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.24A 5d0xH-4c3oA:
undetectable
5d0xN-4c3oA:
undetectable		 5d0xH-4c3oA:
18.17
5d0xN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		6 / 12 ARG C 531
VAL C 373
ALA C 528
THR C 524
GLY C  36
GLY C  33
 None
None
None
NFU  C 701 (-3.8A)
None
None
 1.20A 5h2uA-5aa5C:
undetectable		 5h2uA-5aa5C:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 LEU C 268
PRO C 539
GLY C 393
ASP C 571
ARG C 501
 None
None
None
None
NFU  C 701 (-4.6A)
 1.09A 5h5fA-5aa5C:
undetectable		 5h5fA-5aa5C:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 9 PRO A 534
VAL A 337
LEU A 339
ILE A 345
LEU A  85
 NFU  A1004 (-3.8A)
None
CL  A1587 ( 4.5A)
None
None
 1.37A 5iepA-4c3oA:
undetectable		 5iepA-4c3oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l5zV-3rgwL:
undetectable
5l5zb-3rgwL:
undetectable		 5l5zV-3rgwL:
16.21
5l5zb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 5l5zV-4c3oA:
undetectable
5l5zb-4c3oA:
undetectable		 5l5zV-4c3oA:
18.17
5l5zb-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l5zH-3rgwL:
undetectable
5l5zN-3rgwL:
undetectable		 5l5zH-3rgwL:
16.21
5l5zN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 5l5zH-4c3oA:
undetectable
5l5zN-4c3oA:
undetectable		 5l5zH-4c3oA:
18.17
5l5zN-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l66V-3rgwL:
undetectable
5l66b-3rgwL:
undetectable		 5l66V-3rgwL:
16.21
5l66b-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 5l66V-4c3oA:
undetectable
5l66b-4c3oA:
undetectable		 5l66V-4c3oA:
18.17
5l66b-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l66H-3rgwL:
undetectable
5l66N-3rgwL:
undetectable		 5l66H-3rgwL:
16.21
5l66N-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 11 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 5l66H-4c3oA:
undetectable
5l66N-4c3oA:
undetectable		 5l66H-4c3oA:
18.17
5l66N-4c3oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		6 / 12 GLY C  82
HIS C  88
ASP C  86
VAL C 205
ASP A  33
ILE C  83
 None
NFU  C 701 (-3.6A)
None
None
None
None
 1.38A 5njvA-5aa5C:
undetectable		 5njvA-5aa5C:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 ARG A  74
GLY A  77
GLU A  73
GLY A  81
THR A  82
 None
None
None
None
NFU  A1004 (-4.0A)
 1.24A 5o4yD-4c3oA:
undetectable
5o4yE-4c3oA:
undetectable		 5o4yD-4c3oA:
2.22
5o4yE-4c3oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 8 GLU C 116
CYH C 576
CYH C  81
ARG C 501
 None
NFU  C 701 (-2.2A)
NFU  C 701 (-2.2A)
NFU  C 701 (-4.6A)
 1.05A 5oajD-5aa5C:
undetectable
5oajE-5aa5C:
undetectable		 5oajD-5aa5C:
17.18
5oajE-5aa5C:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		5 / 12 ILE L  70
ILE J  40
ALA J  44
THR J  47
ALA L 134
 NFU  L 401 ( 4.8A)
None
None
None
None
 0.95A 5vceA-6cfwL:
undetectable		 5vceA-6cfwL:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 10 TYR A 529
ALA A  70
ALA A  84
THR A  82
LEU A 515
 None
None
None
NFU  A1004 (-4.0A)
NFU  A1004 (-3.7A)
 1.45A 6ay4A-4c3oA:
undetectable		 6ay4A-4c3oA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		4 / 5 HIS A 122
GLU A 461
HIS A 115
LEU A 515
 None
None
None
NFU  A1004 (-3.7A)
 1.09A 6bc9A-4c3oA:
undetectable		 6bc9A-4c3oA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		3 / 3 ARG A 458
ARG A 512
ASP A 577
 None
NFU  A1004 (-4.6A)
None
 0.97A 6d8pA-4c3oA:
undetectable		 6d8pA-4c3oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.22A 6hwdV-4c3oA:
undetectable
6hwdb-4c3oA:
undetectable		 6hwdV-4c3oA:
10.17
6hwdb-4c3oA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4c3o HYDROGENASE-1 LARGE
SUBUNIT
(Salmonella
enterica) 		5 / 12 HIS A 585
THR A 535
THR A 536
GLY A  29
ALA A 581
 MG  A1005 (-3.7A)
NFU  A1004 (-3.7A)
None
None
None
 1.23A 6hwdH-4c3oA:
undetectable
6hwdN-4c3oA:
undetectable		 6hwdH-4c3oA:
10.17
6hwdN-4c3oA:
11.19