SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NFM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_D_DCFD1853_2 (ADENOSINE DEAMINASE)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	4 / 4	HIS A 191 LEU A 261 LEU A 257 LEU A 284	NFM A 401 ( 4.4A) None None None	1.12A	1a4lD-3ix1A: undetectable	1a4lD-3ix1A: 24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_1 (DIPEPTIDYL PEPTIDASE IV)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	5 / 12	GLU A 192 TYR A 90 ASN A 42 VAL A 44 HIS A 45	NFM A 401 (-2.8A) NFM A 401 (-3.9A) NFM A 401 ( 4.0A) None None	1.30A	1x70A-3ix1A: undetectable	1x70A-3ix1A: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HII_A_PNTA901_0 (AMILORIDE-SENSITIVE AMINE OXIDASE)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	5 / 12	TYR A 139 ASP A 167 ASP A 74 SER A 89 TYR A 90	None None None None NFM A 401 (-3.9A)	1.35A	3hiiA-3ix1A: undetectable	3hiiA-3ix1A: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HII_B_PNTB901_0 (AMILORIDE-SENSITIVE AMINE OXIDASE)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	5 / 12	TYR A 139 ASP A 167 ASP A 74 SER A 89 TYR A 90	None None None None NFM A 401 (-3.9A)	1.36A	3hiiB-3ix1A: undetectable	3hiiB-3ix1A: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_B_D16B530_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	5 / 12	SER A 204 ASN A 116 PHE A 120 TYR A 160 MET A 152	None NFM A 401 ( 4.8A) None None None	1.07A	3nrrB-3ix1A: undetectable	3nrrB-3ix1A: 21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_A_SAMA1281_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	5 / 12	HIS A 117 GLY A 186 GLY A 138 LEU A 115 PRO A 208	None NFM A 401 (-3.6A) None None None	0.87A	4blvA-3ix1A: undetectable	4blvA-3ix1A: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4H_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	4 / 5	GLN A 77 PRO A 75 ILE A 142 ASP A 93	None None NFM A 401 ( 3.9A) None	1.15A	4z4hA-3ix1A: undetectable	4z4hA-3ix1A: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U4S_A_BEZA301_0 (PUTATIVE SHORT CHAIN DEHYDROGENASE)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	4 / 7	ASN A 42 SER A 279 ILE A 282 LEU A 283	NFM A 401 ( 4.0A) None None None	0.90A	5u4sA-3ix1A: undetectable	5u4sA-3ix1A: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNG_A_QPSA601_2 (-)	3ix1	N-FORMYL-4-AMINO-5-A MINOMETHYL-2-METHYLP YRIMIDINE BINDING PROTEIN (Bacillus halodurans)	5 / 12	TYR A 90 HIS A 191 PRO A 214 VAL A 195 GLY A 173	NFM A 401 (-3.9A) NFM A 401 ( 4.4A) None None None	1.19A	6gngA-3ix1A: undetectable	6gngA-3ix1A: 19.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A4L_D_DCFD1853_2","ADENOSINE DEAMINASE","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",4,"HIS A 191;LEU A 261;LEU A 257;LEU A 284","NFM A 401 ( 4.4A);None;None;None","1.12A","1a4lD-3ix1A:undetectable",null],["1X70_A_715A801_1","DIPEPTIDYL PEPTIDASE IV","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",5,"GLU A 192;TYR A  90;ASN A  42;VAL A  44;HIS A  45","NFM A 401 (-2.8A);NFM A 401 (-3.9A);NFM A 401 ( 4.0A);None;None","1.30A","1x70A-3ix1A:undetectable","1a4lD-3ix1A:24.86"],["3HII_A_PNTA901_0","AMILORIDE-SENSITIVE AMINE OXIDASE","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",5,"TYR A 139;ASP A 167;ASP A  74;SER A  89;TYR A  90","None;None;None;None;NFM A 401 (-3.9A)","1.35A","3hiiA-3ix1A:undetectable","1x70A-3ix1A:17.70"],["3HII_B_PNTB901_0","AMILORIDE-SENSITIVE AMINE OXIDASE","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",5,"TYR A 139;ASP A 167;ASP A  74;SER A  89;TYR A  90","None;None;None;None;NFM A 401 (-3.9A)","1.36A","3hiiB-3ix1A:undetectable","3hiiA-3ix1A:18.93"],["3NRR_B_D16B530_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",5,"SER A 204;ASN A 116;PHE A 120;TYR A 160;MET A 152","None;NFM A 401 ( 4.8A);None;None;None","1.07A","3nrrB-3ix1A:undetectable","3hiiB-3ix1A:18.93"],["4BLV_A_SAMA1281_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",5,"HIS A 117;GLY A 186;GLY A 138;LEU A 115;PRO A 208","None;NFM A 401 (-3.6A);None;None;None","0.87A","4blvA-3ix1A:undetectable","3nrrB-3ix1A:21.87"],["4Z4H_A_IPHA904_0","PROTEIN ARGONAUTE-2","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",4,"GLN A  77;PRO A  75;ILE A 142;ASP A  93","None;None;NFM A 401 ( 3.9A);None","1.15A","4z4hA-3ix1A:undetectable","4blvA-3ix1A:22.66"],["5U4S_A_BEZA301_0","PUTATIVE SHORT CHAIN DEHYDROGENASE","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",4,"ASN A  42;SER A 279;ILE A 282;LEU A 283","NFM A 401 ( 4.0A);None;None;None","0.90A","5u4sA-3ix1A:undetectable","4z4hA-3ix1A:17.53"],["6GNG_A_QPSA601_2","-","3ix1","N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDING PROTEIN","Bacillus halodurans",5,"TYR A  90;HIS A 191;PRO A 214;VAL A 195;GLY A 173","NFM A 401 (-3.9A);NFM A 401 ( 4.4A);None;None;None","1.19A","6gngA-3ix1A:undetectable","5u4sA-3ix1A:22.71"]]