SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NFA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N4F_A_ASRA141_0 (LYSOZYME C)	4yjx	ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS 2 (Agrobacterium fabrum)	4 / 6	ASN A 30 ASP A 31 THR A 34 PRO A 35	NFA A 202 (-2.8A) NFA A 202 (-3.3A) NFA A 202 (-4.1A) NFA A 202 ( 4.1A)	0.95A	1n4fA-4yjxA: undetectable	1n4fA-4yjxA: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 12	GLU A 212 ARG A 66 MET A 14 GLY A 27 LEU A 42	IEY A 64 ( 3.6A) IEY A 64 ( 3.0A) NFA A 61 ( 3.7A) None NFA A 61 ( 4.3A)	1.05A	2jfaB-2btjA: undetectable	2jfaB-2btjA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_RALB600_1 (ESTROGEN RECEPTOR)	2gw4	KAEDE (Trachyphyllia geoffroyi)	5 / 12	GLU B 212 ARG B 66 MET A 14 GLY A 27 LEU A 42	RC7 B 63 ( 3.5A) RC7 B 63 ( 3.0A) NFA A 61 ( 3.7A) None NFA A 61 ( 4.3A)	1.08A	2jfaB-2gw4B: undetectable	2jfaB-2gw4B: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3M_A_FOLA1188_0 (DIHYDROFOLATE REDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	5 / 12	LEU A 117 GLN A 257 LEU A 166 TYR A 247 THR A 76	CRK A 214 ( 4.2A) NFA A 213 ( 3.8A) NFA A 213 ( 3.7A) None CRK A 214 ( 4.6A)	1.04A	2w3mA-3u0kA: undetectable	2w3mA-3u0kA: 18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3M_B_FOLB1188_0 (DIHYDROFOLATE REDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	5 / 12	LEU A 117 GLN A 257 LEU A 166 TYR A 247 THR A 76	CRK A 214 ( 4.2A) NFA A 213 ( 3.8A) NFA A 213 ( 3.7A) None CRK A 214 ( 4.6A)	0.99A	2w3mB-3u0kA: undetectable	2w3mB-3u0kA: 18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z0Y_B_SAMB400_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 9	ALA A 103 VAL A 118 GLY A 16 ILE A 56 ALA A 60	None None None None NFA A 61 ( 3.4A)	0.96A	2z0yB-2btjA: undetectable	2z0yB-2btjA: 20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z0Y_B_SAMB400_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657)	2gw4	KAEDE KAEDE (Trachyphyllia geoffroyi; Trachyphyllia geoffroyi)	5 / 9	ALA B 103 VAL B 118 GLY A 16 ILE A 56 ALA A 60	None None None None NFA A 61 ( 3.4A)	0.91A	2z0yB-2gw4B: undetectable	2z0yB-2gw4B: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3u0k	RCAMP (Entacmaea quadricolor)	4 / 6	PHE A 206 HIS A 269 VAL A 255 PHE A 175	NFA A 213 ( 4.7A) None None None	1.01A	4a97E-3u0kA: undetectable	4a97E-3u0kA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KEB_B_FOLB202_0 (DIHYDROFOLATE REDUCTASE)	3u0k	RCAMP (Entacmaea quadricolor)	5 / 12	LEU A 117 GLN A 257 LEU A 166 TYR A 247 THR A 76	CRK A 214 ( 4.2A) NFA A 213 ( 3.8A) NFA A 213 ( 3.7A) None CRK A 214 ( 4.6A)	1.03A	4kebB-3u0kA: undetectable	4kebB-3u0kA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_B_CVIB301_0 (REGULATORY PROTEIN TETR)	2ogr	FLUORESCENT PROTEIN FP538 (Zoanthus sp.)	5 / 12	ALA A 63 GLU A 58 LEU A 46 ILE A 29 PHE A 56	CH7 A 66 ( 4.0A) None NFA A 65 ( 4.4A) NFA A 65 ( 3.9A) None	0.99A	5vlmB-2ogrA: undetectable	5vlmB-2ogrA: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2btj	GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP (Lobophyllia hemprichii)	5 / 12	TRP A 89 LEU A 93 HIS A 194 THR A 58 LEU A 57	IEY A 64 ( 4.0A) None IEY A 64 ( 3.6A) None NFA A 61 ( 4.4A)	1.18A	6djzB-2btjA: undetectable	6djzB-2btjA: 19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2gw4	KAEDE KAEDE (Trachyphyllia geoffroyi; Trachyphyllia geoffroyi)	5 / 12	TRP B 89 LEU B 93 HIS B 194 THR A 58 LEU A 57	RC7 B 63 ( 4.1A) None RC7 B 63 ( 3.6A) None NFA A 61 ( 4.4A)	1.18A	6djzB-2gw4B: undetectable	6djzB-2gw4B: 21.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N4F_A_ASRA141_0","LYSOZYME C","4yjx","ATP-DEPENDENT CLP PROTEASE ADAPTER PROTEIN CLPS 2","Agrobacterium fabrum",4,"ASN A  30;ASP A  31;THR A  34;PRO A  35","NFA A 202 (-2.8A);NFA A 202 (-3.3A);NFA A 202 (-4.1A);NFA A 202 ( 4.1A)","0.95A","1n4fA-4yjxA:undetectable",null],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"GLU A 212;ARG A  66;MET A  14;GLY A  27;LEU A  42","IEY A  64 ( 3.6A);IEY A  64 ( 3.0A);NFA A  61 ( 3.7A);None;NFA A  61 ( 4.3A)","1.05A","2jfaB-2btjA:undetectable","1n4fA-4yjxA:21.95"],["2JFA_B_RALB600_1","ESTROGEN RECEPTOR","2gw4","KAEDE","Trachyphyllia geoffroyi",5,"GLU B 212;ARG B  66;MET A  14;GLY A  27;LEU A  42","RC7 B  63 ( 3.5A);RC7 B  63 ( 3.0A);NFA A  61 ( 3.7A);None;NFA A  61 ( 4.3A)","1.08A","2jfaB-2gw4B:undetectable","2jfaB-2btjA:19.32"],["2W3M_A_FOLA1188_0","DIHYDROFOLATE REDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",5,"LEU A 117;GLN A 257;LEU A 166;TYR A 247;THR A  76","CRK A 214 ( 4.2A);NFA A 213 ( 3.8A);NFA A 213 ( 3.7A);None;CRK A 214 ( 4.6A)","1.04A","2w3mA-3u0kA:undetectable","2jfaB-2gw4B:18.49"],["2W3M_B_FOLB1188_0","DIHYDROFOLATE REDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",5,"LEU A 117;GLN A 257;LEU A 166;TYR A 247;THR A  76","CRK A 214 ( 4.2A);NFA A 213 ( 3.8A);NFA A 213 ( 3.7A);None;CRK A 214 ( 4.6A)","0.99A","2w3mB-3u0kA:undetectable","2w3mA-3u0kA:18.08"],["2Z0Y_B_SAMB400_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"ALA A 103;VAL A 118;GLY A  16;ILE A  56;ALA A  60","None;None;None;None;NFA A  61 ( 3.4A)","0.96A","2z0yB-2btjA:undetectable","2w3mB-3u0kA:18.08"],["2Z0Y_B_SAMB400_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA0657","2gw4","KAEDE;KAEDE","Trachyphyllia geoffroyi;Trachyphyllia geoffroyi",5,"ALA B 103;VAL B 118;GLY A  16;ILE A  56;ALA A  60","None;None;None;None;NFA A  61 ( 3.4A)","0.91A","2z0yB-2gw4B:undetectable","2z0yB-2btjA:20.24"],["4A97_E_ZPCE1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","3u0k","RCAMP","Entacmaea quadricolor",4,"PHE A 206;HIS A 269;VAL A 255;PHE A 175","NFA A 213 ( 4.7A);None;None;None","1.01A","4a97E-3u0kA:undetectable","2z0yB-2gw4B:19.67"],["4KEB_B_FOLB202_0","DIHYDROFOLATE REDUCTASE","3u0k","RCAMP","Entacmaea quadricolor",5,"LEU A 117;GLN A 257;LEU A 166;TYR A 247;THR A  76","CRK A 214 ( 4.2A);NFA A 213 ( 3.8A);NFA A 213 ( 3.7A);None;CRK A 214 ( 4.6A)","1.03A","4kebB-3u0kA:undetectable","4a97E-3u0kA:21.25"],["5VLM_B_CVIB301_0","REGULATORY PROTEIN TETR","2ogr","FLUORESCENT PROTEIN FP538","Zoanthus sp.",5,"ALA A  63;GLU A  58;LEU A  46;ILE A  29;PHE A  56","CH7 A  66 ( 4.0A);None;NFA A  65 ( 4.4A);NFA A  65 ( 3.9A);None","0.99A","5vlmB-2ogrA:undetectable","4kebB-3u0kA:17.89"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","2btj","GREEN TO RED PHOTOCONVERTIBLE GPF-LIKE PROTEIN EOSFP","Lobophyllia hemprichii",5,"TRP A  89;LEU A  93;HIS A 194;THR A  58;LEU A  57","IEY A  64 ( 4.0A);None;IEY A  64 ( 3.6A);None;NFA A  61 ( 4.4A)","1.18A","6djzB-2btjA:undetectable","5vlmB-2ogrA:21.40"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","2gw4","KAEDE;KAEDE","Trachyphyllia geoffroyi;Trachyphyllia geoffroyi",5,"TRP B  89;LEU B  93;HIS B 194;THR A  58;LEU A  57","RC7 B  63 ( 4.1A);None;RC7 B  63 ( 3.6A);None;NFA A  61 ( 4.4A)","1.18A","6djzB-2gw4B:undetectable","6djzB-2btjA:19.62"]]