SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'NEA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		6 / 12 GLU A  45
ILE A  72
ASP A  73
ASP A  89
ASN A 105
PRO A 107
 None
NEA  A 500 (-3.8A)
None
NEA  A 500 (-3.4A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
 0.82A 1qaoA-1g38A:
11.7		 1qaoA-1g38A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		6 / 12 ALA A  49
GLY A  51
ILE A  72
ASP A  73
ASP A  89
PRO A 107
 NEA  A 500 ( 3.7A)
None
NEA  A 500 (-3.8A)
None
NEA  A 500 (-3.4A)
NEA  A 500 (-3.8A)
 0.82A 1sqfA-1g38A:
11.1		 1sqfA-1g38A:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		11 / 11 THR A  23
GLU A  45
ALA A  47
PRO A  52
GLU A  71
ILE A  72
ASP A  73
ALA A  76
ASP A  89
PRO A 107
PHE A 146
 None
None
NEA  A 500 (-3.1A)
None
NEA  A 500 (-2.8A)
NEA  A 500 (-3.8A)
None
NEA  A 500 ( 3.7A)
NEA  A 500 (-3.4A)
NEA  A 500 (-3.8A)
None
 0.28A 2admA-1g38A:
54.5		 2admA-1g38A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		11 / 11 VAL A  21
THR A  23
GLU A  45
ALA A  47
PRO A  52
GLU A  71
ILE A  72
ALA A  76
ASP A  89
PRO A 107
PHE A 146
 NEA  A 500 ( 4.8A)
None
None
NEA  A 500 (-3.1A)
None
NEA  A 500 (-2.8A)
NEA  A 500 (-3.8A)
NEA  A 500 ( 3.7A)
NEA  A 500 (-3.4A)
NEA  A 500 (-3.8A)
None
 0.61A 2admB-1g38A:
54.5		 2admB-1g38A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 12 PHE A 174
PHE A 146
TYR A 143
ALA A  47
TYR A 140
 None
None
None
NEA  A 500 (-3.1A)
None
 1.31A 2igtC-1g38A:
10.0		 2igtC-1g38A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 12 ALA A  47
GLY A  51
ASN A 105
PRO A 107
PHE A 146
 NEA  A 500 (-3.1A)
None
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.98A 2y7hB-1g38A:
18.0		 2y7hB-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		6 / 12 THR A  23
ALA A  47
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 (-3.1A)
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.84A 2y7hB-1g38A:
18.0		 2y7hB-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 12 ALA A  47
GLY A  51
ASN A 105
PRO A 107
PHE A 146
 NEA  A 500 (-3.1A)
None
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.98A 2y7hC-1g38A:
16.1		 2y7hC-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		6 / 12 THR A  23
ALA A  47
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 (-3.1A)
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.84A 2y7hC-1g38A:
16.1		 2y7hC-1g38A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 11 GLU A  71
ILE A  72
ASP A  73
ASP A  89
PRO A 107
 NEA  A 500 (-2.8A)
NEA  A 500 (-3.8A)
None
NEA  A 500 (-3.4A)
NEA  A 500 (-3.8A)
 0.48A 3grvA-1g38A:
7.6		 3grvA-1g38A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		7 / 12 GLU A  45
GLU A  71
ILE A  72
ASP A  73
ASP A  89
ASN A 105
PRO A 107
 None
NEA  A 500 (-2.8A)
NEA  A 500 (-3.8A)
None
NEA  A 500 (-3.4A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
 0.61A 3gryA-1g38A:
14.3		 3gryA-1g38A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		3 / 3 GLU A  71
ASP A  73
ASP A  89
 NEA  A 500 (-2.8A)
None
NEA  A 500 (-3.4A)
 0.33A 4gc9A-1g38A:
10.8		 4gc9A-1g38A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 12 THR A  23
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.68A 5ybbB-1g38A:
18.7		 5ybbB-1g38A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 12 VAL A 121
ASP A  89
PHE A  90
PRO A 107
GLY A 109
 None
NEA  A 500 (-3.4A)
None
NEA  A 500 (-3.8A)
None
 1.46A 6gnfA-1g38A:
undetectable		 6gnfA-1g38A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		5 / 12 VAL A 121
ASP A  89
GLU A 148
PRO A 107
GLY A 109
 None
NEA  A 500 (-3.4A)
None
NEA  A 500 (-3.8A)
None
 1.41A 6gnfC-1g38A:
undetectable		 6gnfC-1g38A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1g38 MODIFICATION
METHYLASE TAQI
(Thermus
aquaticus) 		3 / 3 THR A  23
GLU A  71
ASN A 105
 None
NEA  A 500 (-2.8A)
NEA  A 500 (-4.5A)
 0.82A 6nj9K-1g38A:
10.2		 6nj9K-1g38A:
23.18